Facility Details

Funded by an NIGMS COBRE grant for the Center for Redox Biology and Cardiovascular Diseases, the Animal Models and Histology Core facility provides services for mouse genotyping and tissue histology,  as well as access to state‐of‐the‐art tools for analyzing  cardiovascular function. All services are available on a fee-for-service basis to COBRE and non-COBRE investigators, as well as extramural researchers. This core is divided functionally and spatially into two distinct sub-cores: The Histology and Genotyping Sub-Core. The genotyping component of the Histology and Genotyping Sub-core genotypes mice using PCR or real-time PCR. This subcore also provides a centralized histology service with tissue processing, paraffin-embedding and sectioning, along with several cardiovascular‐relevant histological stains such as Picrosirius Red and Masson’s Trichrome. The Histology and Genotyping Sub-Core. The genotyping component of the Histology and Genotyping Sub-core genotypes mice using PCR or real-time PCR. This subcore also provides a centralized histology service with tissue processing, paraffin-embedding and sectioning, along with several cardiovascular‐relevant histological stains such as Picrosirius Red and Masson’s Trichrome. Both sub-cores have full‐time staff who can perform measurements. The Cardiovascular Phenotyping Sub-core can also provide analysis of data, and can train lab personnel to use the core equipment. The Center for Cardiovascular Diseases and Sciences has a Surgical Models Core in which there is dedicated staff who can generate cardiovascular-related animal models (such as myocardial infarction, middle cerebral artery occlusion) – this core seamlessly interfaces with the Animal Models and Histology Core to provide a genotyping-to-endpoint pipeline for cardiovascular research.