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Beatson Advanced Imaging Resource (BAIR) (Flow Cytometry and Microscopy)

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Switchback Road

Glasgow,

United Kingdom

https://www.crukscotlandinstitute.ac.uk/advanced-technologies/bair.html

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Quicklinks:

https://coremarketplace.org/CRUKSI-BAIR https://coremarketplace.org/RRID:SCR_023875

Facility LIMS Page

https://ppms.eu/glasgow/

Primary Contact:

Claire Mitchell

0000-0001-9960-2340

Last Updated: 05/21/2025

Facility RRID

RRID:SCR_023875

Facility Details

Beatson Advanced Imaging Resource scientists work closely with researchers to uncover and interrogate important molecular pathways in cancer. We train scientists in all stages of modern microscopical research from advice on experimental design and sample preparation, basic and advanced microscope operation and data acquisition through to quantitative image analysis and interpretation.

Facility Policies

Services are offerred outside of Cancer Research UK Scotland Institute

Consulting is offerred outside of Cancer Research UK Scotland Institute

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Services offered:

3D & 4D Image Processing Stations

3D Printing

3D Visualization

Analysis Workstations

Assay Development

Assays and Measurements

Bioimage Informatics

Brightfield Microscopy

Cell Imaging

Confocal Microscopy

Confocal/ Super Resolution Microscope

Data Analysis

Data Analysis And Interpretation

Data Processing

Data Processing And Interpretation

Data Visualization

Deconvolution

Differential Interference Contrast Microscopy

Experimental Design

Fluorescence Lifetime

Fluorescence Microscope With Optical Sectioning Capability

Forster Resonance Energy Transfer (FRET)

High Content Screening

Image Aquisition

Image Data Management

Image Processing And Analysis

Immunofluorescence

In-vivo Imaging

Laser Capture Microdissection

Light-sheet Microscopy

Live Cell Imaging

Microscopy

Multiphoton Microscopy

Multiphoton/ Harmonic Generation Microscope

Optical Imaging

Outreach

Phase Contrast Microscopy

Sample Preparation

Spinning Disk Confocal Imaging

Facility Equipment

No additional equipment has been listed

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Publications

Publications associated with this facility (Click To View):

1.) Thomason PA, Corbyn R, Lilla S, Sumpton D, Gilbey T, Insall RH (2024 Aug 5). Biogenesis of lysosome-related organelles complex-2 is an evolutionarily ancient proto-coatomer complex. Current biology : CB, 34(15), 3564-3581.e6. doi: 10.1016/j.cub.2024.06.081. ID: 39059394.

2.) Mandrou E, Thomason PA, Paschke PI, Paul NR, Tweedy L, Insall RH (2024 Jun 27). A Reliable System for Quantitative G-Protein Activation Imaging in Cancer Cells. Cells, 13(13), . . ID: 38994966.

3.) Matchett KP, Wilson-Kanamori JR, Portman JR, Kapourani CA, Fercoq F, May S, Zajdel E, Beltran M, Sutherland EF, Mackey JBG, Brice M, Wilson GC, Wallace SJ, Kitto L, Younger NT, Dobie R, Mole DJ, Oniscu GC, Wigmore SJ, Ramachandran P, Vallejos CA, Carragher NO, Saeidinejad MM, Quaglia A, Jalan R, Simpson KJ, Kendall TJ, Rule JA, Lee WM, Hoare M, Weston CJ, Marioni JC, Teichmann SA, Bird TG, Carlin LM, Henderson NC (2024 Jun). Multimodal decoding of human liver regeneration. Nature, 630(8015), 158-165. . ID: 38693268.

4.) Derby SJ, Dutton L, Strathdee KE, Stevenson K, Koessinger A, Jackson M, Tian Y, Yu W, Mclay K, Misquitta J, Alsharif S, Clarke CJ, Gilmour L, Thomason P, McGhee E, McGarrity-Cottrell CL, Vanderlinden A, Collis SJ, Rominyi O, Lemgruber L, Solecki G, Olson M, Winkler F, Carlin LM, Heiland DH, Inman GJ, Chalmers AJ, Norman JC, Carruthers R, Birch JL (2024 Apr 5). Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalization via macropinocytosis. Neuro-oncology, 26(4), 625-639. . ID: 37936324.

5.) Santi A, Kay EJ, Neilson LJ, McGarry L, Lilla S, Mullin M, Paul NR, Fercoq F, Koulouras G, Rodriguez Blanco G, Athineos D, Mason S, Hughes M, Thomson G, Kieffer Y, Nixon C, Blyth K, Mechta-Grigoriou F, Carlin LM, Zanivan S (2024 Mar 12). Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function. Science signaling, 17(827), eade0580. doi: 10.1126/scisignal.ade0580. ID: 38470957.

6.) Vringer E, Heilig R, Riley JS, Black A, Cloix C, Skalka G, Montes-Gómez AE, Aguado A, Lilla S, Walczak H, Gyrd-Hansen M, Murphy DJ, Huang DT, Zanivan S, Tait SW (2024 Mar). Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. The EMBO journal, 43(6), 904-930. . ID: 38337057.

7.) Papalazarou V, Newman AC, Huerta-Uribe A, Legrave NM, Falcone M, Zhang T, McGarry L, Athineos D, Shanks E, Blyth K, Vousden KH, Maddocks ODK (2023 Dec). Phenotypic profiling of solute carriers characterizes serine transport in cancer. Nature metabolism, 5(12), 2148-2168. . ID: 38066114.

8.) Hewitt RJ, Puttur F, Gaboriau DCA, Fercoq F, Fresquet M, Traves WJ, Yates LL, Walker SA, Molyneaux PL, Kemp SV, Nicholson AG, Rice A, Roberts E, Lennon R, Carlin LM, Byrne AJ, Maher TM, Lloyd CM (2023 Sep 27). Lung extracellular matrix modulates KRT5(+) basal cell activity in pulmonary fibrosis. Nature communications, 14(1), 6039. . ID: 37758700.

9.) Grotehans N, McGarry L, Nolte H, Xavier V, Kroker M, Narbona-Pérez ÁJ, Deshwal S, Giavalisco P, Langer T, MacVicar T (2023 Sep 18). Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression. The EMBO journal, 42(18), e113256. . ID: 37439264.

10.) Nikolatou K, Sandilands E, Román-Fernández A, Cumming EM, Freckmann E, Lilla S, Buetow L, McGarry L, Neilson M, Shaw R, Strachan D, Miller C, Huang DT, McNeish IA, Norman JC, Zanivan S, Bryant DM (2023 Sep 18). PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer. The EMBO journal, 42(18), e113987. . ID: 37577760.

11.) Vande Voorde J, Steven RT, Najumudeen AK, Ford CA, Dexter A, Gonzalez-Fernandez A, Nikula CJ, Xiang Y, Ford L, Maneta Stavrakaki S, Gilroy K, Zeiger LB, Pennel K, Hatthakarnkul P, Elia EA, Nasif A, Murta T, Manoli E, Mason S, Gillespie M, Lannagan TRM, Vlahov N, Ridgway RA, Nixon C, Raven A, Mills M, Athineos D, Kanellos G, Nourse C, Gay DM, Hughes M, Burton A, Yan B, Sellers K, Wu V, De Ridder K, Shokry E, Huerta Uribe A, Clark W, Clark G, Kirschner K, Thienpont B, Li VSW, Maddocks ODK, Barry S (2023 Aug). Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target. Nature metabolism, 5(8), 1303-1318. . ID: 37580540.

12.) Whyte D, Skalka G, Walsh P, Wilczynska A, Paul NR, Mitchell C, Nixon C, Clarke W, Bushell M, Morton JP, Murphy DJ, Muthalagu N (2023 Jul). NUAK1 governs centrosome replication in pancreatic cancer via MYPT1/PP1β and GSK3β-dependent regulation of PLK4. Molecular oncology, 17(7), 1212-1227. . ID: 36975767.

13.) Abrams B, Pengo T, Wee TL, Deagle RC, Vuillemin N, Callahan LM, Smith MA, Kubow KE, Girard AM, Rappoport JZ, Bayles CJ, Cameron LA, Cole R, Brown CM (2023 Apr 5). Tissue-Like 3D Standard and Protocols for Microscope Quality Management. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 29(2), 616-634. . ID: 37749742.

14.) Sandilands E, Freckmann EC, Cumming EM, Román-Fernández A, McGarry L, Anand J, Galbraith L, Mason S, Patel R, Nixon C, Cartwright J, Leung HY, Blyth K, Bryant DM (2023 Apr 3). The small GTPase ARF3 controls invasion modality and metastasis by regulating N-cadherin levels. The Journal of cell biology, 222(4), . . ID: 36880595.

15.) Schmidt T, Dabrowska A, Waldron JA, Hodge K, Koulouras G, Gabrielsen M, Munro J, Tack DC, Harris G, McGhee E, Scott D, Carlin LM, Huang D, Le Quesne J, Zanivan S, Wilczynska A, Bushell M (2023 Feb 28). eIF4A1-dependent mRNAs employ purine-rich 5 Nucleic acids research, 51(4), 1859-1879. . ID: 36727461.

16.) Román-Fernández A, Mansour MA, Kugeratski FG, Anand J, Sandilands E, Galbraith L, Rakovic K, Freckmann EC, Cumming EM, Park J, Nikolatou K, Lilla S, Shaw R, Strachan D, Mason S, Patel R, McGarry L, Katoch A, Campbell KJ, Nixon C, Miller CJ, Leung HY, Le Quesne J, Norman JC, Zanivan S, Blyth K, Bryant DM (2023 Feb 3). Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Science advances, 9(5), eabq1858. . ID: 36735782.

17.) Freckmann EC, Sandilands E, Cumming E, Neilson M, Román-Fernández A, Nikolatou K, Nacke M, Lannagan TRM, Hedley A, Strachan D, Salji M, Morton JP, McGarry L, Leung HY, Sansom OJ, Miller CJ, Bryant DM (2022 Sep 9). Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging. Nature communications, 13(1), 5317. . ID: 36085324.

18.) Le AH, Yelland T, Paul NR, Fort L, Nikolaou S, Ismail S, Machesky LM (2021 Sep 6). CYRI-A limits invasive migration through macropinosome formation and integrin uptake regulation. The Journal of cell biology, 220(9), . . ID: 34165494.

19.) Yelland T, Garcia E, Samarakoon Y, Ismail S (2021 Jun 15). The Structural and Biochemical Characterization of UNC119B Cargo Binding and Release Mechanisms. Biochemistry, 60(25), 1952-63. . ID: 34130453.

20.) Nacke M, Sandilands E, Nikolatou K, Román-Fernández Á, Mason S, Patel R, Lilla S, Yelland T, Galbraith LCA, Freckmann EC, McGarry L, Morton JP, Shanks E, Leung HY, Markert E, Ismail S, Zanivan S, Blyth K, Bryant DM (2021 Mar 12). An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. Nature communications, 12(1), 1623. . ID: 33712589.

21.) Yelland T, Le AH, Nikolaou S, Insall R, Machesky L, Ismail S (2021 Mar 4). Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1. Structure (London, England : 1993), 29(3), 226-237.e4. . ID: 33217330.

22.) Pickering KA, Gilroy K, Cassidy JW, Fey SK, Najumudeen AK, Zeiger LB, Vincent DF, Gay DM, Johansson J, Fordham RP, Miller B, Clark W, Hedley A, Unal EB, Kiel C, McGhee E, Machesky LM, Nixon C, Johnsson AE, Bain M, Strathdee D, van Hoof SR, Medema JP, Anderson KI, Brachmann SM, Stucke VM, Malliri A, Drysdale M, Turner M, Serrano L, Myant K, Campbell AD, Sansom OJ (2021 Jan 4). A RAC-GEF network critical for early intestinal tumourigenesis. Nature communications, 12(1), 56. . ID: 33397922.

23.) Román-Fernández Á, Roignot J, Sandilands E, Nacke M, Mansour MA, McGarry L, Shanks E, Mostov KE, Bryant DM (2018 Nov 28). The phospholipid PI(3,4)P(2) is an apical identity determinant. Nature communications, 9(1), 5041. . ID: 30487552.

24.) Reid SE, Kay EJ, Neilson LJ, Henze AT, Serneels J, McGhee EJ, Dhayade S, Nixon C, Mackey JB, Santi A, Swaminathan K, Athineos D, Papalazarou V, Patella F, Román-Fernández Á, ElMaghloob Y, Hernandez-Fernaud JR, Adams RH, Ismail S, Bryant DM, Salmeron-Sanchez M, Machesky LM, Carlin LM, Blyth K, Mazzone M, Zanivan S (2017 Aug 15). Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. The EMBO journal, 36(16), 2373-2389. . ID: 28694244.

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Associations

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Metadata

Links

All the links listed resolve to this core profile

https://coremarketplace.org/?FacilityID=1813
https://coremarketplace.org/RRID:SCR_023875

Institution

Institution ROR ID: https://ror.org/03pv69j64

SciCrunch Data Imports (data maintained by https://scicrunch.org)

Keywords:

USEDit, ABRF, molecular pathways in cancer, quantitative image analysis, microscopy

Resource Type:

core facility, access service resource, service resource

Citation:

Beatson Institute for Cancer Research United Kingdom Beatson Advanced Imaging Resource Core Facility (RRID:SCR_023875)

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Other Facilities at Cancer Research UK Scotland Institute

CRUK Scotland Institute Deep Phenotyping Advanced Technology Core FacilityRRID:SCR_027366

Services:

Resources:

Contact Info:

John Le Quesne

https://www.crukscotlandinstitute.ac.uk/advanced-technologies/deep-phenotyping.html

RRID:

RRID:SCR_027366

Description:

We offer a comprehensive pathologist-led spatial biology service comprising spatial proteomic, transcriptomic, and multiomic experimental design, including platform and panel selection, assay development, image acquisition, and digital image processing. The facility houses 2x Ventana Discovery Ultra autostainers, 2x 10 x Genomics Xenium platforms, a Lunaphore COMET, an Akoya PhenoImager, an Akoya PhenoCycler, an Olympus VS200 slide scanner and a Visiopharm image analysis suite. Our multidisciplinary team of pathologists, histologists and expert technicians partner closely with basic scientists to deliver optimal data, to provide training in image analysis, and to answer scientific questions.

This facility does not provide services outside its institution

This facility does not consult outside its institution

Last updated:

09/04/2025

Scotland Institute Molecular Technology Service Core FacilityRRID:SCR_027368

Services:

Resources:

Contact Info:

Graeme Clark

https://www.crukscotlandinstitute.ac.uk/advanced-technologies/molecular-technology.html

RRID:

RRID:SCR_027368

Description:

offers a diverse range of services to individuals and research groups throughout the Institute. The main focus of the facility has centred around the continuing expansion of our Next Generation Sequencing (NGS) services, allied to which, we also offer a range of Single Cell services predominantly focussing on single cell RNAseq.

This facility does not provide services outside its institution

This facility does not consult outside its institution

Last updated:

09/02/2025

Beatson Advanced Imaging Resource (BAIR) (Flow Cytometry and Microscopy)

Quicklinks:

Facility LIMS Page

Primary Contact:

Facility RRID

Facility Details

Facility Policies

(To see more facility information, click the in the upper right)

Services offered:

Facility Equipment

(To see more facility information, click the in the upper right)

Publications

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Associations

(To see more facility information, click the in the upper right)

Metadata

SciCrunch Data Imports (data maintained by https://scicrunch.org)

Facility Profile QR Code (links to this profile)

(To see more facility information, click the in the upper right)

Filter Results. Click/Unclick items to select.

(To see more facility information, click the in the upper right)

Other Facilities at Cancer Research UK Scotland Institute

CRUK Scotland Institute Deep Phenotyping Advanced Technology Core FacilityRRID:SCR_027366

Scotland Institute Molecular Technology Service Core FacilityRRID:SCR_027368

(To see more facility information, click the in the upper right)

Contact Claire Mitchell

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Beatson Advanced Imaging Resource (BAIR)

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