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MRC PPU Reagents and Services

Facility Details

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Services and Equipment

Publications

Awards & Associations

Metadata

Other Facilities at this Institution:

MRC PPU Reagents and Services, School of Life Sciences, University of Dundee

Dundee,

DD1 5EH

United Kingdom

https://mrcppureagents.dundee.ac.uk/

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cite this facility

Primary Contact:

Francesca Tonelli

Last Updated: 02/15/2023

Facility RRID

RRID:SCR_023283

Facility Details

As one of the world\'s leading centres focused on cell signalling pathways, we provide access to the very same reagents and services used by MRC PPU investigators to accelerate research worldwide.

Facility Policies

Services are offerred outside of MRC Protein Phosphorylation and Ubiquitylation Unit

Consulting is offerred outside of MRC Protein Phosphorylation and Ubiquitylation Unit

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Services offered:

Access To Clones

Antibody Characterization

Antibody Development

Antibody Production

Assay Development

Assays and Measurements

Automated Liquid Handling

CRISPR/Cas Project Design

Dub Profiling

Inhibitor Screening

Kinase Screening

Protein Extraction/Purification

Reagents

Repository

Sequencing - DNA Sequencing

Facility Equipment

No additional equipment has been listed

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Publications

Publications associated with this facility (Click To View):

1.) Koch I, Slovik M, Zhang Y, Liu B, Rennie M, Konz E, Cogne B, Daana M, Davids L, Diets IJ, Gold NB, Holtz AM, Isidor B, Mor-Shaked H, Neira Fresneda J, Niederhoffer KY, Nizon M, Pfundt R, Simon M, Stegmann A, Guillen Sacoto MJ, Wevers M, Barakat TS, Yanovsky-Dagan S, Atanassov BS, Toth R, Gao C, Bustos F, Harel T (2024 Mar). USP27X variants underlying X-linked intellectual disability disrupt protein function via distinct mechanisms. Life science alliance, 7(3), . . PMID: 38182161.

2.) Phung TK, Berndsen K, Shastry R, Phan TLCHB, Muqit MMK, Alessi DR, Nirujogi RS (2024 Feb 13). CURTAIN-A unique web-based tool for exploration and sharing of MS-based proteomics data. Proceedings of the National Academy of Sciences of the United States of America, 121(7), e2312676121. . PMID: 38324566.

3.) Zhu H, Tonelli F, Turk M, Prescott A, Alessi DR, Sun J (2023 Dec 22). Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2. Science (New York, N.Y.), 382(6677), 1404-1411. . PMID: 38127736.

4.) Pal P, Taylor M, Lam PY, Tonelli F, Hecht CA, Lis P, Nirujogi RS, Phung TK, Yeshaw WM, Jaimon E, Fasimoye R, Dickie EA, Wightman M, Macartney T, Pfeffer SR, Alessi DR (2023 Dec 15). Parkinson's VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B. Science advances, 9(50), eadj1205. . PMID: 38091401.

5.) Ross FA, Hawley SA, Russell FM, Goodman N, Hardie DG (2023 Dec 13). Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers. The Biochemical journal, 480(23), 1951-1968. . PMID: 37962491.

6.) Evrin C, Alvarez V, Ainsworth J, Fujisawa R, Alabert C, Labib KP (2023 Nov 6). DONSON is required for CMG helicase assembly in the mammalian cell cycle. EMBO reports, 24(11), e57677. . PMID: 37781960.

7.) Xia Y, Sonneville R, Jenkyn-Bedford M, Ji L, Alabert C, Hong Y, Yeeles JTP, Labib KPM (2023 Sep 22). DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans. Science (New York, N.Y.), 381(6664), eadi4932. . PMID: 37590372.

8.) Gregorczyk M, Pastore G, Muñoz I, Carroll T, Streubel J, Munro M, Lis P, Lange S, Lamoliatte F, Macartney T, Toth R, Brown F, Hastie J, Pereira G, Durocher D, Rouse J (2023 Jul). Functional characterization of C21ORF2 association with the NEK1 kinase mutated in human in diseases. Life science alliance, 6(7), . . PMID: 37188479.

9.) Fasimoye R, Dong W, Nirujogi RS, Rawat ES, Iguchi M, Nyame K, Phung TK, Bagnoli E, Prescott AR, Alessi DR, Abu-Remaileh M (2023 May 16). Golgi-IP, a tool for multimodal analysis of Golgi molecular content. Proceedings of the National Academy of Sciences of the United States of America, 120(20), e2219953120. . PMID: 37155866.

10.) Hanna JC, Corpas-Lopez V, Seizova S, Colon BL, Bacchetti R, Hall GMJ, Sands EM, Robinson L, Baragaña B, Wyllie S, Pawlowic MC (2023). Mode of action studies confirm on-target engagement of lysyl-tRNA synthetase inhibitor and lead to new selection marker for Cryptosporidium. Frontiers in cellular and infection microbiology, 13(), 1236814. . PMID: 37600947.

11.) Blanca Ramírez M, Lara Ordóñez AJ, Fdez E, Madero-Pérez J, Gonnelli A, Drouyer M, Chartier-Harlin MC, Taymans JM, Bubacco L, Greggio E, Hilfiker S (2017 Jul 15). GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2. Human molecular genetics, 26(14), 2747-2767. . PMID: 28453723.

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Associations

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Metadata

Links

All the links listed resolve to this core profile

https://coremarketplace.org/?FacilityID=1687
https://coremarketplace.org/RRID:SCR_023283

Institution

Institution ROR ID: https://ror.org/01zg1tt02

SciCrunch Data Imports (data maintained by https://scicrunch.org)

Keywords:

USEDit, ABRF, cell signalling pathways, reagents and services, kinase, ubiquitin targets, protein generation, antibody development,

Resource Type:

service resource, core facility, access service resource

Citation:

MRC Protein Phosphorylation and Ubiquitylation Unit MRC PPU Reagents and Services Core Facility (RRID:SCR_023283)

MRC PPU Reagents and Services

Primary Contact:

Facility RRID

Facility Details

Facility Policies

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Services offered:

Facility Equipment

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Publications

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Associations

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Metadata

SciCrunch Data Imports (data maintained by https://scicrunch.org)

Facility Profile QR Code (links to this profile)

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