University of Pennsylvania

Contact Info:

Sara Cherry

https://www.med.upenn.edu/cores/assets/user-content/documents/HTSC_overview_27May2015.pdf

Grants and Identifiers:

RRID: RRID:SCR_022379

Instrumentation:

Services Provided:

Relevant Publications:

1.) Riscal R, Gardner SM, Coffey NJ, Carens M, Mesaros C, Xu JP, Xue Y, Davis L, Demczyszyn S, Vogt A, Olia A, Finan JM, Godfrey J, Schultz DC, Blair IA, Keith B, Marmorstein R, Skuli N, Simon MC (2024 May 15). Bile acid metabolism mediates cholesterol homeostasis and promotes tumorigenesis in clear cell renal cell carcinoma Cancer research, 84(10), 1570-1582. . PMCID: 11096083.

Description:

Core provides distribution of lentivirus based shRNA and cDNA plasmid DNA clones; technical expertise in developing biological assays (i.e. biochemical-, cell-, and high-content) in miniaturized, multiwell microtiter plates that are laboratory automation compatible; high-throughput chemical and functional genomic screening, including data analysis and interpretation. Our goal is to use cutting biological models to discover genes and small molecules that enable scientists to further study functions of poorly understood proteins, signaling pathways, and cells in complex biological process relevant to human physiology and disease.