Facility Details

Core provides structural biology support for UofL Health – Brown Cancer Center (BCC) scientists, with particular emphasis on characterization of biophysical properties of biomolecules (including proteins, peptides, lipids, and polynucleotides) and their interactions with binding partners or novel drug candidates. Offers range of biophysical techniques for both initial screening of lead compound binding as well as rigorous characterization of thermodynamic and hydrodynamic properties of various biological macromolecules (most commonly proteins and nucleic acids), macromolecular association reactions, and drug-macromolecule interactions. Biophysical techniques include differential scanning fluorimetry, microscale thermophoresis, isothermal titration calorimetry, differential scanning calorimetry, circular dichroism spectroscopy, fluorescence spectroscopy, absorbance spectroscopy and analytical ultracentrifugation.