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Wake Forest University
1834 Wake Forest Rd.
Winston Salem, NC 27106United States of Americahttps://microscopy.wfu.edu
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Last Updated: 06/22/2022
Light Microscopy and Scanning Electron Microscopy Facility managed by the Biology Department
Services are not offerred outside of Wake Forest University
Consulting is not offerred outside of Wake Forest University
Nikon SMZ-1 Microscope
Nikon SMZ-1 and SMZ-1B zoom stereo microscopes offer legendary Nikon stereo performance. Developed to fit a variety of applications and OEM needs, these advanced-design stereo microscopes have the features and image quality you expect from Nikon. High-performance optics and a 6V/10W halogen illuminator deliver images with excellent contrast, resolution, and brightness. The SMZ-1 and SMZ-1B are human-engineered to allow long periods of operation without fatigue. Mechanical design is yet rugged for daily trouble-free operation in industrial, laboratory, and classroom environments. All controls are easy to use. Nikon's versatile modular approach allows the SMZ-1/1B to be easily adapted to various configurations such as stand, arm, or table mounting. Similarly, the illuminator can be fixed to the instrument stand, placed in a diascopic base, or attached externally for oblique lighting. The SMZ-1/1B use a Nikon-designed twin-lens objective system inclined at 12o. Only the center of the lenses is used to provide the sharpest three-dimensional image and enable the operator to work more accurately and efficiently for prolonged periods without eye strain. [Product Link]
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Zeiss LSM 710 Confocal Inverted Microscope
LSM 710 is a confocal is an inverted microscope that enables confocal microscopy for a wide variety of applications. You work with up to ten dyes and use continuous spectral detection across the complete wavelength range. With the inverse Axio Observer from Carl Zeiss, LSM 710 offers you unrivalled confocal microscopy in cell and developmental biology. Upright stands such as Axio Imager or Axio Examiner offer you have all the equipment you need to record neurobiological, physiological and developmental relationships to an exceptional standard. [Product Link]
Citation IDs: S10 RR027301
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Zeiss LSM 880 with Airyscan Confocal Laser Scanning Microscope
Fully enclosed laser scanning confocal imaging microscopefor heating and environmental control with media perfusion capabilities and CO2 control. It can be used for Live Cell Imaging, FRET and Anisotropy, FRAP and FLIP, FCS, Photoactivation/ -conversion. [Product Link]
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Zeiss AxioZoom V16 Stereomicroscope
Echo Revolve4 Microscope
Zeiss AxioObserver D1
Amray 1810 Scanning Electron Microscope
Publications associated with this facility (Click To View):
1.) Hu Q, Yammani RD, Brown-Harding H, Soto-Pantoja DR, Poole LB, Lukesh JC 3rd (2022 Jul). Mitigation of doxorubicin-induced cardiotoxicity with an H<sub>2</sub>O<sub>2</sub>-Activated, H<sub>2</sub>S-Donating hybrid prodrug. Redox biology, 53(), 102338. . ID: 35609400.
2.) Martin RE, Marzol E, Estevez JM, Muday GK (2022 Jun 17). Ethylene signaling increases reactive oxygen species accumulation to drive root hair initiation in Arabidopsis. Development (Cambridge, England), (), . . ID: 35713303.
3.) Lee H, Bonin K, Guthold M (2021 Jun). Human mammary epithelial cells in a mature, stratified epithelial layer flatten and stiffen compared to single and confluent cells. Biochimica et biophysica acta. General subjects, 1865(6), 129891. . ID: 33689830.
4.) Dushime R, Zhu Y, Wu H, Saez D, Shukla K, Brown-Harding H, Biavatti MW, Nelson KJ, Poole LB, Lowther WT, Jones PB, Furdui CM, Tsang AW (2020 Dec 3). Discovery of Spilanthol Endoperoxide as a Redox Natural Compound Active against Mammalian Prx3 and <i>Chlamydia</i> <i>trachomatis</i> Infection. Antioxidants (Basel, Switzerland), 9(12), . . ID: 33287170.
5.) Yao X, Watkins NH, Brown-Harding H, Bierbach U (2020 Sep 16). A membrane transporter determines the spectrum of activity of a potent platinum-acridine hybrid anticancer agent. Scientific reports, 10(1), 15201. doi: 10.1038/s41598-020-72099-z. ID: 32939009.
6.) Gayomba SR, Muday GK (2020 Apr 27). Flavonols regulate root hair development by modulating accumulation of reactive oxygen species in the root epidermis. Development (Cambridge, England), 147(8), . . ID: 32179566.
7.) Suarez SI, Warner CC, Brown-Harding H, Thooft AM, VanVeller B, Lukesh JC (2020 Jan 22). Highly selective staining and quantification of intracellular lipid droplets with a compact push-pull fluorophore based on benzothiadiazole. Organic & biomolecular chemistry, 18(3), 495-499. doi: 10.1039/c9ob02486g. ID: 31850447.
9.) Luessen DJ, Sun H, McGinnis MM, Hagstrom M, Marrs G, McCool BA, Chen R (2019 Sep 20). Acute ethanol exposure reduces serotonin receptor 1A internalization by increasing ubiquitination and degradation of β-arrestin2. The Journal of biological chemistry, 294(38), 14068-14080. . ID: 31366729.
10.) Chapman JM, Muhlemann JK, Gayomba SR, Muday GK (2019 Mar 18). RBOH-Dependent ROS Synthesis and ROS Scavenging by Plant Specialized Metabolites To Modulate Plant Development and Stress Responses. Chemical research in toxicology, 32(3), 370-396. doi: 10.1021/acs.chemrestox.9b00028. ID: 30781949.
11.) Saez D, Dushime R, Wu H, Ramos Cordova LB, Shukla K, Brown-Harding H, Furdui CM, Tsang AW (2019 Jan). Sulforaphane promotes chlamydial infection by suppressing mitochondrial protein oxidation and activation of complement C3. Protein science : a publication of the Protein Society, 28(1), 216-227. doi: 10.1002/pro.3536. ID: 30367535.
12.) Muhlemann JK, Younts TLB, Muday GK (2018 Nov 20). Flavonols control pollen tube growth and integrity by regulating ROS homeostasis during high-temperature stress. Proceedings of the National Academy of Sciences of the United States of America, 115(47), E11188-E11197. . ID: 30413622.
14.) Holmila RJ, Vance SA, Chen X, Wu H, Shukla K, Bharadwaj MS, Mims J, Wary Z, Marrs G, Singh R, Molina AJ, Poole LB, King SB, Furdui CM (2018 Apr 27). Mitochondria-targeted Probes for Imaging Protein Sulfenylation. Scientific reports, 8(1), 6635. doi: 10.1038/s41598-018-24493-x. ID: 29703899.
15.) Watkins JM, Chapman JM, Muday GK (2017 Dec). Abscisic Acid-Induced Reactive Oxygen Species Are Modulated by Flavonols to Control Stomata Aperture. Plant physiology, 175(4), 1807-1825. . ID: 29051198.
16.) Van Nest BN, Wagner AE, Marrs GS, Fahrbach SE (2017 Sep). Volume and density of microglomeruli in the honey bee mushroom bodies do not predict performance on a foraging task. Developmental neurobiology, 77(9), 1057-1071. doi: 10.1002/dneu.22492. ID: 28245532.
17.) Zheng Y, Fahrenholtz CD, Hackett CL, Ding S, Day CS, Dhall R, Marrs GS, Gross MD, Singh R, Bierbach U (2017 Mar 8). Large-Pore Functionalized Mesoporous Silica Nanoparticles as Drug Delivery Vector for a Highly Cytotoxic Hybrid Platinum-Acridine Anticancer Agent. Chemistry (Weinheim an der Bergstrasse, Germany), 23(14), 3386-3397. doi: 10.1002/chem.201604868. ID: 28122141.
18.) Blume LC, Leone-Kabler S, Luessen DJ, Marrs GS, Lyons E, Bass CE, Chen R, Selley DE, Howlett AC (2016 Nov). Cannabinoid receptor interacting protein suppresses agonist-driven CB<sub>1</sub> receptor internalization and regulates receptor replenishment in an agonist-biased manner. Journal of neurochemistry, 139(3), 396-407. doi: 10.1111/jnc.13767. ID: 27513693.
19.) Luessen DJ, Hinshaw TP, Sun H, Howlett AC, Marrs G, McCool BA, Chen R (2016 Nov). RGS2 modulates the activity and internalization of dopamine D2 receptors in neuroblastoma N2A cells. Neuropharmacology, 110(), 297-307. . ID: 27528587.
20.) Chapman JM, Muday GK (2021 Jan-Jun). Flavonols modulate lateral root emergence by scavenging reactive oxygen species in Arabidopsis thaliana. The Journal of biological chemistry, 296(), 100222. . ID: 33839683.
USEDit, ABRF, Light Microscopy, Scanning Electron Microscopy
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Wake Forest University Microscopic Imaging Core Facility (RRID:SCR_021975)
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