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Interdisciplinary Neurobehavioral Core INBC

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Behavioral Research

Facility Address

Heidelberg University

Im Neuenheimer Feld 515

3 OG

Heidelberg,

69120

Germany

http://www.medizinische-fakultaet-hd.uni-heidelberg.de/Home.111344.0.html

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https://coremarketplace.org/INBC-Heidelberg https://coremarketplace.org/RRID:SCR_019153

Primary Contact:

Claudia Pitzer

Facility RRID

RRID:SCR_019153

Facility Details

The Interdisciplinary Neurobehavioral Core is a multidisciplinary in vivo core facility at Heidelberg University. The CF is equipped with state-of-art equipment for detailed behavioral analyses and surgical procedures in the context of mouse and rat models of neurological, cognitive and psychiatric disorders. We aim to facilitate collaborative projects for basic scientists and clinically oriented researchers and to disseminate expertises and innovation.

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Consulting is offerred outside of Heidelberg University

Last Updated: 04/21/2021

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Services offered:

Animal Husbandry

Behavioral Phenotyping

Surgical Services

Facility Equipment

Morris Water Maze
T-Maze
Radial Maze
Novel Object Recognition
Active Place Avoidance
Passive Avoidance
Fear Conditioning
Puzzle box
Intellicage
Open Field Activity Test
Grip Strength Test
Rotarod Performance Test
Horizontal Ladder Test (grid walk)
Inclined Platform Test (for BBB Scoring)
Montoya's Staircase Test
Species-typical behaviors according to Deacon (burrowing and nesting)
LABORAS (Metris) home cage for continuous behavioral monitoring
Running wheels
CATWALK XT 10 for gait analysis
Treadmill
Cylinder test
Parallel Rod Floor test
Hole board exploration test
Dark-light exploration test
Ultrasonic vocalization
Social interaction
Forced Swim Test
Anxiety test: successive alleys test
Elevated Plus Maze
Shuttle box
Cliff avoidance
Successive bars
Plantar (Hargraeves) test
Hot / cold plate
von Frey test for mechanical sensitivity
Dynamic weight bearing test
Thermal place preference test
Conditioned place preference (CPP)
Place escape avoidance paradigm (PEAP)
Ultrasonic vocalization AVISOFT
UTAS Visual Diagnostic System with BigShot™
The AlphaLab SnR: Deep brain stimulation

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Publications

Publications associated with this facility (Click To View):

1.) Simonetti M, Paldy E, Njoo C, Bali KK, Worzfeld T, Pitzer C, Kuner T, Offermanns S, Mauceri D, Kuner R (2021 Apr). The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology. Molecular psychiatry, 26(4), 1376-1398. doi: 10.1038/s41380-019-0491-4. ID: 31444474.

2.) Wahis J, Baudon A, Althammer F, Kerspern D, Goyon S, Hagiwara D, Lefevre A, Barteczko L, Boury-Jamot B, Bellanger B, Abatis M, Da Silva Gouveia M, Benusiglio D, Eliava M, Rozov A, Weinsanto I, Knobloch-Bollmann HS, Kirchner MK, Roy RK, Wang H, Pertin M, Inquimbert P, Pitzer C, Siemens J, Goumon Y, Boutrel B, Lamy CM, Decosterd I, Chatton JY, Rouach N, Young WS, Stern JE, Poisbeau P, Stoop R, Darbon P, Grinevich V, Charlet A (2021 Apr). Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents. Nature neuroscience, 24(4), 529-541. doi: 10.1038/s41593-021-00800-0. ID: 33589833.

3.) Eltokhi A, Kurpiers B, Pitzer C (2021 Mar 22). Comprehensive characterization of motor and coordination functions in three adolescent wild-type mouse strains. Scientific reports, 11(1), 6497. doi: 10.1038/s41598-021-85858-3. ID: 33753800.

4.) Kos-Braun IC, Gerlach B, Pitzer C (2020 Nov 26). A survey of research quality in core facilities. eLife, 9(), . pii: e62212. doi: 10.7554/eLife.62212. ID: 33241998.

5.) Agarwal N, Taberner FJ, Rangel Rojas D, Moroni M, Omberbasic D, Njoo C, Andrieux A, Gupta P, Bali KK, Herpel E, Faghihi F, Fleming T, Dejean A, Lechner SG, Nawroth PP, Lewin GR, Kuner R (2020 Sep 23). SUMOylation of Enzymes and Ion Channels in Sensory Neurons Protects against Metabolic Dysfunction, Neuropathy, and Sensory Loss in Diabetes. Neuron, 107(6), 1141-1159.e7. . ID: 32735781.

6.) Walter J, Kovalenko O, Younsi A, Grutza M, Unterberg A, Zweckberger K (2020 Aug 17). The CatWalk XT® is a valid tool for objective assessment of motor function in the acute phase after controlled cortical impact in mice. Behavioural brain research, 392(), 112680. . ID: 32479852.

7.) Hirth M, Gandla J, Höper C, Gaida MM, Agarwal N, Simonetti M, Demir A, Xie Y, Weiss C, Michalski CW, Hackert T, Ebert MP, Kuner R (2020 Aug). CXCL10 and CCL21 Promote Migration of Pancreatic Cancer Cells Toward Sensory Neurons and Neural Remodeling in Tumors in Mice, Associated With Pain in Patients. Gastroenterology, 159(2), 665-681.e13. . ID: 32330476.

8.) Eltokhi A, Kurpiers B, Pitzer C (2020 Jul 9). Behavioral tests assessing neuropsychiatric phenotypes in adolescent mice reveal strain- and sex-specific effects. Scientific reports, 10(1), 11263. doi: 10.1038/s41598-020-67758-0. ID: 32647155.

9.) La Porta C, Tappe-Theodor A (2020 Jul). Differential impact of psychological and psychophysical stress on low back pain in mice. Pain, 161(7), 1442-1458. doi: 10.1097/j.pain.0000000000001850. ID: 32132393.

10.) Schlüter A, Aksan B, Diem R, Fairless R, Mauceri D (2020 Jun 12). VEGFD Protects Retinal Ganglion Cells and, consequently, Capillaries against Excitotoxic Injury. Molecular therapy. Methods & clinical development, 17(), 281-299. doi: 10.1016/j.omtm.2019.12.009. ID: 32055648.

11.) Bojcevski J, Stojic A, Hoffmann DB, Williams SK, Müller A, Diem R, Fairless R (2020 Jun). Influence of retinal NMDA receptor activity during autoimmune optic neuritis. Journal of neurochemistry, 153(6), 693-709. doi: 10.1111/jnc.14980. ID: 32031240.

12.) Younsi A, Zheng G, Scherer M, Riemann L, Zhang H, Tail M, Hatami M, Skutella T, Unterberg A, Zweckberger K (2020 May). Treadmill training improves survival and differentiation of transplanted neural precursor cells after cervical spinal cord injury. Stem cell research, 45(), 101812. doi: 10.1155/2020/5674921. ID: 32361314.

13.) Younsi A, Zheng G, Scherer M, Riemann L, Zhang H, Tail M, Hatami M, Skutella T, Unterberg A, Zweckberger K (2020). Three Growth Factors Induce Proliferation and Differentiation of Neural Precursor Cells In Vitro and Support Cell-Transplantation after Spinal Cord Injury In Vivo. Stem cells international, 2020(), 5674921. doi: 10.1155/2020/5674921. ID: 32774390.

14.) Fröhlich H, Kollmeyer ML, Linz VC, Stuhlinger M, Groneberg D, Reigl A, Zizer E, Friebe A, Niesler B, Rappold G (2019 Oct 29). Gastrointestinal dysfunction in autism displayed by altered motility and achalasia in Foxp1 +/- mice. Proceedings of the National Academy of Sciences of the United States of America, 116(44), 22237-22245. . ID: 31611379.

15.) Jakobs M, Pitzer C, Sartorius A, Unterberg A, Kiening K (2019 Oct 15). Acute 5 Hz deep brain stimulation of the lateral habenula is associated with depressive-like behavior in male wild-type Wistar rats. Brain research, 1721(), 146283. . ID: 31170383.

16.) Hasan MT, Althammer F, Silva da Gouveia M, Goyon S, Eliava M, Lefevre A, Kerspern D, Schimmer J, Raftogianni A, Wahis J, Knobloch-Bollmann HS, Tang Y, Liu X, Jain A, Chavant V, Goumon Y, Weislogel JM, Hurlemann R, Herpertz SC, Pitzer C, Darbon P, Dogbevia GK, Bertocchi I, Larkum ME, Sprengel R, Bading H, Charlet A, Grinevich V (2019 Jul 3). A Fear Memory Engram and Its Plasticity in the Hypothalamic Oxytocin System. Neuron, 103(1), 133-146.e8. . ID: 31104950.

17.) Treede RD, Schuh-Hofer S, Magerl W, La Porta C, Tappe-Theodor A (2019 Jul). Combination pharmacotherapy for tackling descending controls and central sensitization. European journal of pain (London, England), 23(6), 1049-1050. doi: 10.1002/ejp.1396. ID: 30929296.

18.) Stojic A, Bojcevski J, Williams SK, Bas-Orth C, Nessler S, Linington C, Diem R, Fairless R (2019 Mar). Preclinical stress originates in the rat optic nerve head during development of autoimmune optic neuritis. Glia, 67(3), 512-524. doi: 10.1002/glia.23560. ID: 30578556.

19.) Pitzer C, La Porta C, Treede RD, Tappe-Theodor A (2019 Feb). Inflammatory and neuropathic pain conditions do not primarily evoke anxiety-like behaviours in C57BL/6 mice. European journal of pain (London, England), 23(2), 285-306. doi: 10.1002/ejp.1303. ID: 30098102.

20.) Peleh T, Eltokhi A, Pitzer C (2019). Longitudinal analysis of ultrasonic vocalizations in mice from infancy to adolescence: Insights into the vocal repertoire of three wild-type strains in two different social contexts. PloS one, 14(7), e0220238. doi: 10.1371/journal.pone.0220238. ID: 31365551.

21.) Zhao K, Wang Z, Hackert T, Pitzer C, Zöller M (2018 Dec 12). Tspan8 and Tspan8/CD151 knockout mice unravel the contribution of tumor and host exosomes to tumor progression. Journal of experimental & clinical cancer research : CR, 37(1), 312. doi: 10.1186/s13046-018-0961-6. ID: 30541597.

22.) Rojas DR, Tegeder I, Kuner R, Agarwal N (2018 Dec). Hypoxia-inducible factor 1α protects peripheral sensory neurons from diabetic peripheral neuropathy by suppressing accumulation of reactive oxygen species. Journal of molecular medicine (Berlin, Germany), 96(12), 1395-1405. doi: 10.1007/s00109-018-1707-9. ID: 30361814.

23.) Williams SK, Fairless R, Maier O, Liermann PC, Pichi K, Fischer R, Eisel ULM, Kontermann R, Herrmann A, Weksler B, Romero N, Couraud PO, Pfizenmaier K, Diem R (2018 Sep 11). Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis. Scientific reports, 8(1), 13628. doi: 10.1038/s41598-018-31957-7. ID: 30206422.

24.) Stojic A, Bojcevski J, Williams SK, Diem R, Fairless R (2018 May 1). Early Nodal and Paranodal Disruption in Autoimmune Optic Neuritis. Journal of neuropathology and experimental neurology, 77(5), 361-373. doi: 10.1002/glia.23560. ID: 29444299.

25.) Riemann L, Younsi A, Scherer M, Zheng G, Skutella T, Unterberg AW, Zweckberger K (2018). Transplantation of Neural Precursor Cells Attenuates Chronic Immune Environment in Cervical Spinal Cord Injury. Frontiers in neurology, 9(), 428. doi: 10.3389/fneur.2018.00428. ID: 29951030.

26.) Herzer S, Hagan C, von Gerichten J, Dieterle V, Munteanu B, Sandhoff R, Hopf C, Nordström V (2018). Deletion of Specific Sphingolipids in Distinct Neurons Improves Spatial Memory in a Mouse Model of Alzheimer Frontiers in molecular neuroscience, 11(), 206. doi: 10.3389/fnmol.2018.00206. ID: 29973867.

27.) Dehler S, Lou WP, Gao L, Skabkin M, Dällenbach S, Neumann A, Martin-Villalba A (2018). An Immune-CNS Axis Activates Remote Hippocampal Stem Cells Following Spinal Transection Injury. Frontiers in molecular neuroscience, 11(), 443. doi: 10.3389/fnmol.2018.00443. ID: 30618602.

28.) Neureither F, Ziegler K, Pitzer C, Frings S, Möhrlen F (2017 Dec). Impaired Motor Coordination and Learning in Mice Lacking Anoctamin 2 Calcium-Gated Chloride Channels. Cerebellum (London, England), 16(5), 929-937. doi: 10.1007/s12311-017-0867-4. ID: 28536821.

29.) Tan LL, Pelzer P, Heinl C, Tang W, Gangadharan V, Flor H, Sprengel R, Kuner T, Kuner R (2017 Nov). A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity. Nature neuroscience, 20(11), 1591-1601. . ID: 28920932.

30.) Kumar V, Fleming T, Terjung S, Gorzelanny C, Gebhardt C, Agrawal R, Mall MA, Ranzinger J, Zeier M, Madhusudhan T, Ranjan S, Isermann B, Liesz A, Deshpande D, Häring HU, Biswas SK, Reynolds PR, Hammes HP, Peperkok R, Angel P, Herzig S, Nawroth PP (2017 Oct 13). Homeostatic nuclear RAGE-ATM interaction is essential for efficient DNA repair. Nucleic acids research, 45(18), 10595-10613. . ID: 28977635.

31.) Bröker-Lai J, Kollewe A, Schindeldecker B, Pohle J, Nguyen Chi V, Mathar I, Guzman R, Schwarz Y, Lai A, Weißgerber P, Schwegler H, Dietrich A, Both M, Sprengel R, Draguhn A, Köhr G, Fakler B, Flockerzi V, Bruns D, Freichel M (2017 Sep 15). Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory. The EMBO journal, 36(18), 2770-2789. . ID: 28790178.

32.) Gandla J, Lomada SK, Lu J, Kuner R, Bali KK (2017 Sep). miR-34c-5p functions as pronociceptive microRNA in cancer pain by targeting Cav2.3 containing calcium channels. Pain, 158(9), 1765-1779. doi: 10.1097/j.pain.0000000000000971. ID: 28614186.

33.) Paldy E, Simonetti M, Worzfeld T, Bali KK, Vicuña L, Offermanns S, Kuner R (2017 Aug 2). Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain. Nature communications, 8(1), 176. doi: 10.1038/s41467-017-00341-w. ID: 28765520.

34.) Selvaraj D, Hirth M, Gandla J, Kuner R (2017 Aug). A mouse model for pain and neuroplastic changes associated with pancreatic ductal adenocarcinoma. Pain, 158(8), 1609-1621. doi: 10.1097/j.pain.0000000000000956. ID: 28715356.

35.) Neureither F, Stowasser N, Frings S, Möhrlen F (2017 Aug). Tracking of unfamiliar odors is facilitated by signal amplification through anoctamin 2 chloride channels in mouse olfactory receptor neurons. Physiological reports, 5(15), . . ID: 28784854.

36.) Fröhlich H, Rafiullah R, Schmitt N, Abele S, Rappold GA (2017 Apr 15). Foxp1 expression is essential for sex-specific murine neonatal ultrasonic vocalization. Human molecular genetics, 26(8), 1511-1521. . ID: 28204507.

37.) Brings S, Fleming T, De Buhr S, Beijer B, Lindner T, Wischnjow A, Kender Z, Peters V, Kopf S, Haberkorn U, Mier W, Nawroth PP (2017 Mar). A scavenger peptide prevents methylglyoxal induced pain in mice. Biochimica et biophysica acta. Molecular basis of disease, 1863(3), 654-662. . ID: 27932057.

38.) Lanz TV, Williams SK, Stojic A, Iwantscheff S, Sonner JK, Grabitz C, Becker S, Böhler LI, Mohapatra SR, Sahm F, Küblbeck G, Nakamura T, Funakoshi H, Opitz CA, Wick W, Diem R, Platten M (2017 Jan 24). Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis. Scientific reports, 7(), 41271. . ID: 28117398.

39.) Stojic A, Fairless R, Beck SC, Sothilingam V, Weissgerber P, Wissenbach U, Gimmy V, Seeliger MW, Flockerzi V, Diem R, Williams SK (2017 Jan 1). Murine Autoimmune Optic Neuritis Is Not Phenotypically Altered by the Retinal Degeneration 8 Mutation. Investigative ophthalmology & visual science, 58(1), 318-328. . ID: 28114593.

40.) Pitzer C, Kuner R, Tappe-Theodor A (2016 Jul). Voluntary and evoked behavioral correlates in inflammatory pain conditions under different social housing conditions. Pain reports, 1(1), e564. doi: 10.1097/PR9.0000000000000564. ID: 29392189.

41.) Eliava M, Melchior M, Knobloch-Bollmann HS, Wahis J, da Silva Gouveia M, Tang Y, Ciobanu AC, Triana Del Rio R, Roth LC, Althammer F, Chavant V, Goumon Y, Gruber T, Petit-Demoulière N, Busnelli M, Chini B, Tan LL, Mitre M, Froemke RC, Chao MV, Giese G, Sprengel R, Kuner R, Poisbeau P, Seeburg PH, Stoop R, Charlet A, Grinevich V (2016 Mar 16). A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing. Neuron, 89(6), 1291-1304. . ID: 26948889.

42.) Pitzer C, Kuner R, Tappe-Theodor A (2016). EXPRESS: Voluntary and evoked behavioral correlates in neuropathic pain states under different housing conditions. Molecular pain, 12(1), e564. doi: 10.1097/PR9.0000000000000564. ID: 27306409.

43.) Njoo C, Agarwal N, Lutz B, Kuner R (2015 Oct). The Cannabinoid Receptor CB1 Interacts with the WAVE1 Complex and Plays a Role in Actin Dynamics and Structural Plasticity in Neurons. PLoS biology, 13(10), e1002286. doi: 10.1371/journal.pbio.1002286. ID: 26496209.

44.) Selvaraj D, Gangadharan V, Michalski CW, Kurejova M, Stösser S, Srivastava K, Schweizerhof M, Waltenberger J, Ferrara N, Heppenstall P, Shibuya M, Augustin HG, Kuner R (2015 Jun 8). A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain. Cancer cell, 27(6), 780-96. . ID: 26058077.

45.) Vicuña L, Strochlic DE, Latremoliere A, Bali KK, Simonetti M, Husainie D, Prokosch S, Riva P, Griffin RS, Njoo C, Gehrig S, Mall MA, Arnold B, Devor M, Woolf CJ, Liberles SD, Costigan M, Kuner R (2015 May). The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase. Nature medicine, 21(5), 518-23. . ID: 25915831.

46.) Wallner S, Peters S, Pitzer C, Resch H, Bogdahn U, Schneider A (2015). The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity. Frontiers in cell and developmental biology, 3(), 48. doi: 10.3389/fcell.2015.00048. ID: 26301221.

47.) Agarwal N, Helmstädter J, Rojas DR, Bali KK, Gangadharan V, Kuner R (2018 Jan-Dec). Evoked hypoalgesia is accompanied by tonic pain and immune cell infiltration in the dorsal root ganglia at late stages of diabetic neuropathy in mice. Molecular pain, 14(), 1744806918817975. doi: 10.1177/1744806918817975. ID: 30453826.

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https://coremarketplace.org/RRID:SCR_019153

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Institution ROR ID: https://ror.org/038t36y30

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Keywords:

ABRF, ABRF

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access service resource, core facility, service resource

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University of Heidelberg Interdisciplinary Neurobehavioral Core Facility (RRID:SCR_019153)

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DKFZ Small Animal Imaging Core FacilityRRID:SCR_025301

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Animal Imaging

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Manfred Jugold

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https://www.dkfz.de/en/kleintierbildgebung/index.html

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RRID:SCR_025301

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Supports users in application of numerous radiological methods such as ultrasound, optical imaging, µPET, µCT, µSPECT and MRT measurements to collect and quantify morphological and functional data in vivo.

This facility does not provide services outside its institution

This facility does not consult outside its institution

Last updated:

05/07/2024

Interdisciplinary Neurobehavioral Core INBC

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Metadata

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DKFZ Small Animal Imaging Core FacilityRRID:SCR_025301

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Interdisciplinary Neurobehavioral Core INBC

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