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Robarts Research Institute
1151 Richmond Street North
London, ON N6A5B7Canadahttps://www.lrgc.ca
Last Updated: 10/05/2021
The LRGC provides Illumina Next Generation Sequencing, single cell RNA-seq and spatial transcriptomics, qPCR and Sanger sequencing services, along with consultation and data analysis.
Services are offerred outside of Robarts Research Institute
Consulting is offerred outside of Robarts Research Institute
10X Genomics Chromium Plus Genetic Analyzer
Genetic analyzer, referred to as Chromium Controller for combining large partition numbers with a diverse barcode library to generate >100,000 barcode-containing partitions. [Product Link]
Illumina MiSeq System
Access focused applications such as targeted resequencing, metagenomics, small genome sequencing, targeted gene expression profiling, and more. MiSeq reagents enable up to 15 Gb of output with 25 million sequencing reads and 2 Ã— 300 bp read lengths. [Product Link]
Illumina NextSeq 550 System
With tunable output and high data quality, it provides flexible power you need for whole genome, transcriptome, and targeted resequencing plus ability to scan microarrays including Infinium MethylationEPIC BeadChip and other select BeadChips. [Product Link]
Applied Biosystems ViiA
ViiA 7 System provides enhanced fluorescence detection and enables more accurate and sensitive data analysis. [Product Link]
Applied Biosystems 3730 Genetic Analyzer
The 48-capillary 3730 DNA Analyzer is a medium-to-high throughput genetic analyzer that performs DNA fragment analysis applications such as microsatellites, AFLP, SNP analysis, mutation detection and traditional DNA sequencing. This is upgradeable to 96 capillaries. [Product Link]
2100 Bioanalyzer Instrument
The 2100 Bioanalyzer system is an automated electrophoresis tool that provides precise analytical evaluation of various samples types in many workflows, including next generation sequencing (NGS), gene expression, biopharmaceutical, and gene editing research. Digital data is provided in a timely manner and delivers objective assessment of sizing, quantitation, integrity and purity from DNA, RNA, and proteins. Minimal sample volumes are required for an accurate result, and the data may be exported in a many different formats for ease-of-use. [Product Link]
Facilitates library construction system for NGS platforms, and is recommended by Illumina and Ion Torrent for certain workflows. The platform features the ability to collect narrow and even fragment distributions, as well as the flexibility to collect wide ranges of fragments with minimal effort. Target sizes or ranges of sizes are entered in software, and fractions are collected in buffer. Up to 5 samples per gel cassette may be run, with no possibility of cross contamination. [Product Link]
Thermo Fisher Qubit 2.0 Fluorometer Qubit 2.0
Invitrogen Qubit Flex Fluorometer can selectively, accurately measure the concentration of up to 8 samples of DNA, RNA or protein simultaneously. Compared to single sample microvolume fluorometers, using the Qubit Flex Fluorometer for multiple samples reduces your time to data by up to 50%, with time savings beginning with batches of as few as 8 samples. Combining the one-of-a-kind Qubit Flex Fluorometer and optimized Invitrogen Qubit reagents and tube strips offers a complete solution for DNA, RNA and protein quantification. [Product Link]
Thermo Scientific Nanodrop 1000 Spectrophotometer
The Thermo Scientific NanoDrop™ 1000 is a spectrophotometer that performs measuring of 1 ul samples with high accuracy and reproducibility. The full spectrum (220nm-750nm) spectrophotometer utilizes a patented sample retention technology that employs surface tension alone to hold the sample in place. This eliminates the need for cumbersome cuvettes and other sample containment devices and allows for clean up in seconds. In addition, the NanoDrop 1000 Spectrophotometer has the capability to measure highly concentrated samples without dilution (50X higher concentration than the samples measured by a standard cuvette spectrophotometer). [Product Link]
No additional equipment has been listed
Publications associated with this facility (Click To View):
2.) May SC, Dron JS, Hegele RA, Sahoo D (2021). Human variant of scavenger receptor BI (R174C) exhibits impaired cholesterol transport functions. Journal of lipid research, 62(), 100045. . PMID: 33577783.
3.) Awan ZA, Rashidi OM, Al-Shehri BA, Jamil K, Elango R, Al-Aama JY, Hegele RA, Banaganapalli B, Shaik NA (2021). Saudi Familial Hypercholesterolemia Patients With Rare LDLR Stop Gain Variant Showed Variable Clinical Phenotype and Resistance to Multiple Drug Regimen. Frontiers in medicine, 8(), 694668. doi: 10.3389/fmed.2021.694668. PMID: 34249980.
4.) Gill SE, Dos Santos CC, O'Gorman DB, Carter DE, Patterson EK, Slessarev M, Martin C, Daley M, Miller MR, Cepinskas G, Fraser DD (2020 Dec 11). Transcriptional profiling of leukocytes in critically ill COVID19 patients: implications for interferon response and coagulation. Intensive care medicine experimental, 8(1), 75. doi: 10.1186/s40635-020-00361-9. PMID: 33306162.
5.) Al KF, Denstedt JD, Daisley BA, Bjazevic J, Welk BK, Pautler SE, Gloor GB, Reid G, Razvi H, Burton JP (2020 Sep 22). Ureteral Stent Microbiota Is Associated with Patient Comorbidities but Not Antibiotic Exposure. Cell reports. Medicine, 1(6), 100094. doi: 10.1016/j.xcrm.2020.100094. PMID: 33205072.
6.) Mann JFS, Pankrac J, Klein K, McKay PF, King DFL, Gibson R, Wijewardhana CN, Pawa R, Meyerowitz J, Gao Y, Canaday DH, Avino M, Poon AFY, Foster C, Fidler S, Shattock RJ, Arts EJ (2020 Sep). A targeted reactivation of latent HIV-1 using an activator vector in patient samples from acute infection. EBioMedicine, 59(), 102853. . PMID: 32654992.
7.) Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG (2020 Jun 30). Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits. Cell reports, 31(13), 107838. . PMID: 32610139.
8.) Zhao PJ, Ban MR, Iacocca MA, McIntyre AD, Wang J, Hegele RA (2019 Sep). Genetic Determinants of Myocardial Infarction Risk in Familial Hypercholesterolemia. CJC open, 1(5), 225-230. doi: 10.1016/j.cjco.2019.06.001. PMID: 32159113.
Next, generation, sequencing, bioinformatics, RNA, assessment, RNAseq, DNAseq, miRNAseq, ChIPseq, microbiome, single, cell, analysis, service, core, ABRF
core facility, access service resource, service resource
London Regional Genomics Centre Core Facility (RRID:SCR_017865)
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