The RI-INBRE Molecular Informatics Core provides services in sequencing (Illumina MiSeq, Sanger), bioinformatics analysis, access to molecular modeling software, and development of virtual reality applications. We are an NIH Data Sciences Core for Biomedical Research serving the Rhode Island community and are able to provide services to both biomedical and environmental researchers.
Facility Policies
Services are offerred outside of University of Rhode Island
Consulting is offerred outside of University of Rhode Island
The Applied Biosystems® 3130 (4-capillary) Genetic Analyzer is an electrophoresis device for the low to medium throughput laboratories that provides industry-leading performance and sophisticated automation capabilities. It can run a wide variety of sequencing and fragment analysis applications including microsatellite analysis, AFLP, LOH, SNP validation, and SNP screening. Maintenance time is reduced by eliminating manual syringe washing and filling with automated polymer delivery. The 3130 can increase your data quality for sequencing and fragment analysis applications – longer read length, and higher resolution with shorter run times. The 3130 can increase laboratory productivity and turnaround time by processing 96- or 384-well plates with a four-capillary array. [Product Link]
2100 Bioanalyzer system is an established automated electrophoresis tool for the sample quality control of biomolecules. The 2100 Bioanalyzer instrument, together with the 2100 Expert Software and Bioanalyzer assays, provide highly precise analytical evaluation of various samples types in many workflows, including next generation sequencing (NGS), gene expression, biopharmaceutical, and gene editing research. Digital data is provided in a timely manner and delivers objective assessment of sizing, quantitation, integrity and purity from DNA, RNA, and proteins. Minimal sample volumes are required for an accurate result, and the data may be exported in a many different formats for ease-of-use. [Product Link]
Access focused applications such as targeted resequencing, metagenomics, small genome sequencing, targeted gene expression profiling, and more. MiSeq reagents enable up to 15 Gb of output with 25 million sequencing reads and 2 × 300 bp read lengths. [Product Link]
We have access to the URI Bluewaves computing cluster and cloud resources for larger scale bioinformatics analyses.
We have a small lab with two PC's and 3 laptops used for molecular modeling (2 Spartan licenses, 2 Molecular Operating Environment licenses) and VR/AR app development (HTC Vive, HTC Cosmos, Looking Glass holodisplay, etc). We also have access to the College of Pharmacy 3D printer for printing of macromolecule structures.
Publications
Publications associated with this facility (Click To View):
