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CERVO Canadian Optogenetics and vectorology Foundry core (Viral Vector)

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CERVO Brain Research Centre

2601 de la Canardiere, F-7500

Quebec, QC G1J 2G3

Canada

https://neurophotonics.ca/canadian-optogenetics-vectorology-foundry

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Primary Contact:

Marie-Eve Paquet

Last Updated: 05/19/2025

Facility RRID

RRID:SCR_016477

Additional Citation Identifiers

Brain Canada Foundation

Facility Details

We offer a molecular biology service, genetically encoded light sensitive molecules design as well as viral vector production. We package adenoviruses, AAV, lentiviruses, retroviruses and G-deleted Rabies viruses mostly for optogenetics use. We offer custom services for optogenetics and viral vector production.

Facility Policies

Services are offerred outside of Université Laval

Consulting is offerred outside of Université Laval

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Services offered:

Cloning

CRISPR/Cas Project Design

Flow Cytometric Analysis

Flow Cytometry Data Analysis

Fluorescence Lifetime

Molecular Construct Services

Multi-color Flow Cytometry

Multiphoton Microscopy

Nucleic Acid Extraction

Real-time qPCR

Super-resolution Microscopy

Surface Plasmon Resonance

Surface Plasmon Resonance (SPR)

Ultrasonic Imaging

Viral Vectors

Virology

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No additional equipment has been listed

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Publications

Publications associated with this facility (Click To View):

1.) Bono BS, Negishi K, Dumiaty Y, Ponce‐Ruiz MS, Akinbode TC, Baker KS, Spencer CD, Mejia E, Guirguis M, Hebert AJ, Khan AM, Chee MJ (2025 Mar 16). Brainwide Projections of Mouse Dopaminergic Zona Incerta Neurons The Journal of Comparative Neurology, 533(3), e70039. . PMCID: 11911292.

2.) Hernandez G, Zhao J, Niu Z, MacGowan D, Capolicchio T, Song A, Gul S, Moiz A, Herrera I, Day JJ, Flores C (2025 Mar 2). Amphetamine in Adolescence Induces a Sex-Specific Mesolimbic Dopamine Phenotype in the Adult Prefrontal Cortex bioRxiv, (), 2025.02.26.640363. . PMCID: 11888448.

3.) Srikanta SB, Brown TW, Malescot A, Cloutier M, Zhu L, Coutanson C, Malki M, Storch K, Rungta R, Cayouette M, Dkhissi‐Benyahya O, Cermakian N (2025 Feb 18). The Deubiquitinase USP2 Modulates Photic Entrainment of the Circadian Clock at the Level of the Suprachiasmatic Nucleus Journal of Neurochemistry, 169(2), e70018. . PMCID: 11836553.

4.) Tamboli S, Topolnik D, Radhakrishnan R, Veilleux-Lemieux D, Topolnik L (2024 Oct 18). Protocol for synchronized wireless fiber photometry and video recordings in rodents during behavior STAR Protocols, 5(4), 103407. . PMCID: 11513555.

5.) Raveendran VA, Serranilla M, Asgarihafshejani A, de Saint-Rome M, Cherednychenko M, Mullany S, Mitchell JA, Pressey JC, Woodin MA (2024 Oct 11). SNARE protein SNAP25 regulates the chloride-transporter KCC2 in neurons iScience, 27(11), 111156. . PMCID: 11539599.

6.) Fatt MP, Zhang MD, Kupari J, Altınkök M, Yang Y, Hu Y, Svenningsson P, Ernfors P (2024 Aug 30). Morphine-responsive neurons that regulate mechanical antinociception Science (New York, N.Y.), 385(6712), eado6593. . PMCID: 7616448.

7.) Wong C, Rodriguez-Hernandez LD, Lister KC, Gu N, Cai W, Hooshmandi M, Fan J, Brown N, Nguyen V, Ribeiro-da-Silva A, Bonin RP, Khoutorsky A (2024 Aug 21). Targeting spinal mechanistic target of rapamycin complex 2 alleviates inflammatory and neuropathic pain. Brain : a journal of neurology, (), . pii: awae275. doi: 10.1093/brain/awae275. PMID: 39167538.

8.) Cloarec-Ung FM, Beaulieu J, Suthananthan A, Lehnertz B, Sauvageau G, Sheppard HM, Knapp DJ (2024 Jun 3). Near-perfect precise on-target editing of human hematopoietic stem and progenitor cells eLife, 12(), RP91288. . PMCID: 11147503.

9.) Wu X, Yang L, Li Z, Gu C, Jin K, Luo A, Rasheed NF, Fiutak I, Chao K, Chen A, Mao J, Chen Q, Ding W, Shen S (2024 May 17). Aging‐associated decrease of PGC‐1α promotes pain chronification Aging Cell, 23(8), e14177. . PMCID: 11320346.

10.) Juárez Tello A, van der Zouwen CI, Dejas L, Duque-Yate J, Boutin J, Medina-Ortiz K, Suresh JS, Swiegers J, Sarret P, Ryczko D (2024 May 8). Dopamine-sensitive neurons in the mesencephalic locomotor region control locomotion initiation, stop, and turns Cell Reports, 43(5), 114187. . PMCID: 11157412.

11.) Celinskis D, Black CJ, Murphy J, Barrios-Anderson A, Friedman NG, Shaner NC, Saab CY, Gomez-Ramirez M, Borton DA, Moore CI (2024 May 7). Toward a brighter constellation: multiorgan neuroimaging of neural and vascular dynamics in the spinal cord and brain Neurophotonics, 11(2), 024209. . PMCID: 11079446.

12.) Tamboli S, Singh S, Topolnik D, El Amine Barkat M, Radhakrishnan R, Guet-McCreight A, Topolnik L (2024 Apr 23). Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory. Cell reports, 43(4), 114115. doi: 10.1016/j.celrep.2024.114115. PMID: 38607918.

13.) Stanley S, Devarakonda K, O’Connor R, Jimenez-Gonzalez M, Alvarsson A, Hampton R, Espinoza D, Li R, Shtekler A, Conner K, Bayne M, Garibay D, Martin J, Lehmann V, Wang L, Kenny P (2024 Mar 29). Amygdala-liver signaling orchestrates rapid glycemic responses to stress and drives stress-induced metabolic dysfunction Research Square, (), rs.3.rs-2924278. . PMCID: 10996786.

14.) Benevento M, Alpár A, Gundacker A, Afjehi L, Balueva K, Hevesi Z, Hanics J, Rehman S, Pollak DD, Lubec G, Wulff P, Prevot V, Horvath TL, Harkany T (2024 Mar 27). A brainstem–hypothalamus neuronal circuit reduces feeding upon heat exposure Nature, 628(8009), 826-834. . PMCID: 11041654.

15.) Sagalajev B, Zhang T, Abdollahi N, Yousefpour N, Medlock L, Al-Basha D, Ribeiro-da-Silva A, Esteller R, Ratté S, Prescott SA (2024 Feb 7). Absence of paresthesia during high-rate spinal cord stimulation reveals importance of synchrony for sensations evoked by electrical stimulation. Neuron, 112(3), 404-420.e6. doi: 10.1016/j.neuron.2023.10.021. PMID: 37972595.

16.) Cai J, Jiang Y, Xu Y, Jiang Z, Young C, Li H, Ortiz-Guzman J, Zhuo Y, Li Y, Xu Y, Arenkiel BR, Tong Q (2024 Feb 7). An excitatory projection from the basal forebrain to the ventral tegmental area that underlies anorexia-like phenotypes. Neuron, 112(3), 458-472.e6. . PMID: 38056455.

17.) Wu M, Zhang X, Feng S, Freda SN, Kumari P, Dumrongprechachan V, Kozorovitskiy Y (2024 Jan 3). Dopamine pathways mediating affective state transitions after sleep loss. Neuron, 112(1), 141-154.e8. . PMID: 37922904.

18.) Celinskis D, Black CJ, Murphy J, Barrios-Anderson A, Friedman N, Shaner NC, Saab C, Gomez-Ramirez M, Lipscombe D, Borton DA, Moore CI (2023 Dec 27). Towards a Brighter Constellation: Multi-Organ Neuroimaging of Neural and Vascular Dynamics in the Spinal Cord and Brain bioRxiv, (), 2023.12.25.573323. . PMCID: 10793404.

19.) Keramidis I, McAllister BB, Bourbonnais J, Wang F, Isabel D, Rezaei E, Sansonetti R, Degagne P, Hamel JP, Nazari M, Inayat S, Dudley JC, Barbeau A, Froux L, Paquet ME, Godin AG, Mohajerani MH, De Koninck Y (2023 Dec 1). Restoring neuronal chloride extrusion reverses cognitive decline linked to Alzheimer's disease mutations. Brain : a journal of neurology, 146(12), 4903-4915. . PMID: 37551444.

20.) Cain SM, Alles SR, Gopaul R, Bernier LP, Yung AC, Bauman A, Yang Y, Baker GB, Kozlowski P, MacVicar BA, Snutch TP (2023 Nov 3). Chronic pregabalin treatment protects against spreading depolarization and alters hippocampal synaptic characteristics in a model of familial hemiplegic migraine-type 1 Molecular Brain, 16(), 76. . PMCID: 10623724.

21.) Wong C, Tavares-Ferreira D, Thörn Perez C, Sharif B, Uttam S, Amiri M, Lister KC, Hooshmandi M, Nguyen V, Séguéla P, Sonenberg N, Price TJ, Gkogkas CG, Khoutorsky A (2023 Nov 3). 4E-BP1–dependent translation in nociceptors controls mechanical hypersensitivity via TRIM32/type I interferon signaling Science Advances, 9(44), eadh9603. . PMCID: 10624345.

22.) Weilinger NL, Yang K, Choi HB, Groten CJ, Wendt S, Murugan M, Wicki-Stordeur LE, Bernier LP, Velayudhan PS, Zheng J, LeDue JM, Rungta RL, Tyson JR, Snutch TP, Wu LJ, MacVicar BA (2023 Oct 31). Pannexin-1 opening in neuronal edema causes cell death but also leads to protection via increased microglia contacts. Cell reports, 42(10), 113128. . PMID: 37742194.

23.) Martianova E, Sadretdinova R, Pageau A, Pausic N, Gentiletti TD, Leblanc D, Rivera AM, Labonté B, Proulx CD (2023 Oct 24). Hypothalamic neuronal outputs transmit sensorimotor signals at the onset of locomotor initiation iScience, 26(11), 108328. . PMCID: 10665817.

24.) Patel N, Ouellet V, Paquet-Mercier F, Chetoui N, Bélanger E, Paquet ME, Godin AG, Marquet P (2023 Sep 25). A robust and reliable methodology to perform GECI-based multi-time point neuronal calcium imaging within mixed cultures of human iPSC-derived cortical neurons Frontiers in Neuroscience, 17(), 1247397. . PMCID: 10560759.

25.) Weilinger NL, Yang K, Choi HB, Groten CJ, Wendt S, Murugan M, Wicki-Stordeur LE, Bernier LP, Velayudhan PS, Zheng J, LeDue JM, Rungta RL, Tyson JR, Snutch TP, Wu LJ, MacVicar BA (2023 Sep 23). Pannexin-1 opening in neuronal edema causes initial cell death but also leads to protection via increased microglia contacts Cell reports, 42(10), 113128. . PMCID: 10824275.

26.) Dawson M, Terstege DJ, Jamani N, Tsutsui M, Pavlov D, Bugescu R, Epp JR, Leinninger GM, Sargin D (2023 Jul 25). Hypocretin/orexin neurons encode social discrimination and exhibit a sex-dependent necessity for social interaction. Cell reports, 42(7), 112815. doi: 10.1016/j.celrep.2023.112815. PMID: 37459234.

27.) Stil A, Liberelle B, Guadarrama Bello D, Lacomme L, Arpin L, Parent P, Nanci A, Dumont ÉC, Ould-Bachir T, Vanni MP, De Crescenzo G, Bouchard JF (2023 Jun 21). A simple method for poly-D-lysine coating to enhance adhesion and maturation of primary cortical neuron cultures in vitro Frontiers in Cellular Neuroscience, 17(), 1212097. . PMCID: 10320290.

28.) Xu Y, Jiang Z, Li H, Cai J, Jiang Y, Otiz-Guzman J, Xu Y, Arenkiel BR, Tong Q (2023 May 30). Lateral septum as a melanocortin downstream site in obesity development. Cell reports, 42(5), 112502. . PMID: 37171957.

29.) Fortin-Houde J, Henderson F, Dumas S, Ducharme G, Amilhon B (2023 May). Parallel streams of raphe VGLUT3-positive inputs target the dorsal and ventral hippocampus in each hemisphere. The Journal of comparative neurology, 531(7), 702-719. doi: 10.1002/cne.25452. PMID: 36855269.

30.) Zhou H, Li M, Zhao R, Sun L, Yang G (2023 Mar). A sleep-active basalocortical pathway crucial for generation and maintenance of chronic pain. Nature neuroscience, 26(3), 458-469. . PMID: 36690899.

31.) Servonnet A, Rompré PP, Samaha AN (2023 Feb 25). Optogenetic activation of basolateral amygdala-to-nucleus accumbens core neurons promotes Pavlovian approach responses but not instrumental pursuit of reward cues. Behavioural brain research, 440(), 114254. doi: 10.1016/j.bbr.2022.114254. PMID: 36516942.

32.) Roussel M, Lafrance-Zoubga D, Josset N, Lemieux M, Bretzner F (2023 Feb 21). Functional contribution of mesencephalic locomotor region nuclei to locomotor recovery after spinal cord injury. Cell reports. Medicine, 4(2), 100946. . PMID: 36812893.

33.) Bilash OM, Chavlis S, Johnson CD, Poirazi P, Basu J (2023 Jan 31). Lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuit. Cell reports, 42(1), 111962. . PMID: 36640337.

34.) Roque PS, Thörn Perez C, Hooshmandi M, Wong C, Eslamizade MJ, Heshmati S, Brown N, Sharma V, Lister KC, Goyon VM, Neagu-Lund L, Shen C, Daccache N, Sato H, Sato T, Mogil JS, Nader K, Gkogkas CG, Iordanova MD, Prager-Khoutorsky M, McBride HM, Lacaille JC, Wykes L, Schricker T, Khoutorsky A (2023 Jan 17). Parvalbumin interneuron loss mediates repeated anesthesia-induced memory deficits in mice The Journal of Clinical Investigation, 133(2), e159344. . PMCID: 9843048.

35.) Das A, Margevicius D, Borovicka J, Icardi J, Patel D, Paquet ME, Dana H (2023 Jan 10). Enhanced detection sensitivity of neuronal activity patterns using CaMPARI1 vs. CaMPARI2 Frontiers in Neuroscience, 16(), 1055554. . PMCID: 9871923.

36.) Yang J, Serrano P, Yin X, Sun X, Lin Y, Chen SX (2022 Oct 19). Functionally distinct NPAS4-expressing somatostatin interneuron ensembles critical for motor skill learning. Neuron, 110(20), 3339-3355.e8. doi: 10.1016/j.neuron.2022.08.018. PMID: 36099920.

37.) Jimenez-Gonzalez M, Li R, Pomeranz LE, Alvarsson A, Marongiu R, Hampton RF, Kaplitt MG, Vasavada RC, Schwartz GJ, Stanley SA (2022 Jul 14). Mapping and targeted viral activation of pancreatic nerves in mice reveal their roles in the regulation of glucose metabolism Nature biomedical engineering, 6(11), 1298-1316. . PMCID: 9669304.

38.) Bono BS, Koziel Ly NK, Miller PA, Williams-Ikhenoba J, Dumiaty Y, Chee MJ (2022 Jul). Spatial distribution of beta-klotho mRNA in the mouse hypothalamus, hippocampal region, subiculum, and amygdala. The Journal of comparative neurology, 530(10), 1634-1657. doi: 10.1002/cne.25306. PMID: 35143049.

39.) Huzard D, Martin M, Maingret F, Chemin J, Jeanneteau F, Mery PF, Fossat P, Bourinet E, François A (2022 Jun 29). The impact of C-tactile low-threshold mechanoreceptors on affective touch and social interactions in mice Science Advances, 8(26), eabo7566. . PMCID: 9242590.

40.) Ruthazer ES, Béïque JC, De Koninck Y (2022 May 17). Editorial: Shedding Light on the Nervous System: Progress in Neurophotonics Research Frontiers in Neural Circuits, 16(), 901376. . PMCID: 9156792.

41.) De Saint Jan D (2022 Feb 28). Target-specific control of olfactory bulb periglomerular cells by GABAergic and cholinergic basal forebrain inputs. eLife, 11(), . pii: e71965. doi: 10.7554/eLife.71965. PMID: 35225232.

42.) Cain SM, Bernier LP, Zhang Y, Yung AC, Kass J, Bohnet B, Yang Y, Gopaul R, Kozlowski P, MacVicar BA, Snutch TP (2022 Jan 19). Hyperexcitable superior colliculus and fatal brainstem spreading depolarization in a model of Sudden Unexpected Death in Epilepsy Brain Communications, 4(2), fcac006. . PMCID: 9035526.

43.) Rochon PL, Theriault C, Rangel Olguin AG, Krishnaswamy A (2021 Sep 21). The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges. eLife, 10(), . pii: e70870. doi: 10.7554/eLife.70870. PMID: 34545809.

44.) Bilodeau G, Gagnon-Turcotte G, Gagnon LL, Keramidis I, Timofeev I, De Koninck Y, Ethier C, Gosselin B (2021). A Wireless Electro-Optic Platform for Multimodal Electrophysiology and Optogenetics in Freely Moving Rodents. Frontiers in neuroscience, 15(), 718478. doi: 10.3389/fnins.2021.718478. PMID: 34504415.

45.) Colmers PLW, Bains JS (2018 Dec 5). Presynaptic mGluRs Control the Duration of Endocannabinoid-Mediated DSI. The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(49), 10444-10453. . PMID: 30355625.

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https://coremarketplace.org/?FacilityID=681
https://coremarketplace.org/RRID:SCR_016477

Institution

Institution ROR ID: https://ror.org/04sjchr03

SciCrunch Data Imports (data maintained by https://scicrunch.org)

Keywords:

ABRF, Adenovirus, retrovirus, lentivirus, viral vector production, molecular construction production, molecular construction design, molecular construction cloning, ABRF, optogenetics

Resource Type:

service resource, core facility, access service resource

Citation:

CERVO Canadian Optogenetics and Vectorology Foundry Core Facility (RRID:SCR_016477)

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Other Facilities at Université Laval

ULaval_CHU_Proteomics PlatformRRID:SCR_021025

Services:

Computational - Bioinformatics

Phosphoproteomics

Proteomics

Sample Preparation

Resources:

Proteomics

Contact Info:

Florence Roux-Dalvai

2705 Laurier boulevard

Room R-2710

Quebec, QC G1V 4G2 - Canada

http://www.crchudequebec.ulaval.ca/en/services/proteomics/

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RRID:

RRID:SCR_021025

Description:

Proteomics platform offers sample preparation, protein identification, post-translational modification (PTM) protein analysis, protein quantification (Label Free, Label based and targeted proteomics by MRM or PRM) by mass spectrometry and statistical or functional bioinformatics analyses

This facility provides services outside its institution

This facility provides consulting outside its institution

Last updated:

06/23/2023

CERVO Canadian Optogenetics and vectorology Foundry core (Viral Vector)

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Facility RRID

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Other Facilities at Université Laval

ULaval_CHU_Proteomics PlatformRRID:SCR_021025

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CERVO Canadian Optogenetics and vectorology Foundry core

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