Leica Microsystems and Fred Hutch collaborated to establish the first Leica Center of Excellence, or CoE, in the Pacific Northwest. The Leica CoE establishes a mutually beneficial, collaborative relationship through a combined effort to provide researchers with advanced microscopy technologies, while supporting the Hutch’s commitment to generating scientific discoveries and developing new approaches to preventing and treating cancer and related diseases.

The Therapeutic Products shared resource at Fred Hutchinson Cancer Center provides facilities and services in process development and manufacturing of Good Manufacturing Practice (GMP)-grade biologic and cellular therapeutic products for Phase 1/2 clinical trials. Our vision is to support the translation of ideas from academic laboratories to clinical trials.

Through Shared Resources, investigators in Fred Hutch/University of Washington Cancer Consortium and external academic and industry organizations can access services tailored to their specific research goals, including novel assay development or early access to new technologies.

Since our inception in 1995, Fred Hutch’s Antibody Technology shared resource has worked with research teams inside and outside the Hutch to design campaign strategies for the generation and identification of novel monoclonal antibody compositions. Our projects encompass a range of applications in oncology, viral therapeutics and diagnostics.

The Cellular Imaging shared resource at Fred Hutch provides advanced light microscopy services for biomedical and translational research. Our expert staff provides a complete workflow, including training for independent, 24/7 work in the core; assistance and technical support in microscopy techniques and their application; and tailored quantitative image analysis. We also offer training and support for imaging and analyzing gels and blots. We work with Fred Hutch users as well as external users from academia and industry.

Fred Hutch and Leica Microsystems have combined efforts to establish a Leica Center of Excellence in the Cellular Imaging core in support of a mission to drive new discoveries and insights from scientific research performed using the imaging systems.

The Comparative Medicine shared resource provides a variety of research support services. All our facilities are fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC) International and comply with all U.S. Department of Agriculture, Public Health Service, Washington state and local area regulations.

Offers techniques to resolve structures from cellular ultrastructure to molecular interactions. Offers expertise in EM sample preparation and imaging, cryogenic electron microscopy, technologies and services, training through complexities of electron microscopy workflow, from sample preparation to image processing. All users must be trained by core staff.

Provides expertise in anatomic pathology technologies. Offers routine and special staining,  immunohistochemistry, in situ hybridization and digital pathology in support of internal and external investigators who rely on histological analysis.

Includes services from sterile cell sorting for therapeutic applications to whole cell mass spectrometry, diagnostics and early stage clinical trials. Provides expertise from experimental design to data analysis and troubleshooting, therapeutic cell sorting. Supports isolation of cells for Phase 1 clinical trials of cellular immunotherapies.

The Hutch Data Core helps investigators integrate, interpret and explore large and diverse datasets. We provide services that support efficient and reproducible analysis of large-scale datasets for biomedical researchers, drawing on deep expertise in computational biology, software engineering and cloud architecture.
We aim to make it possible for all interested investigators to apply advanced analytical techniques to complex datasets. Our diverse team offers project-based scientific analysis by expert bioinformaticians, automation of analytical pipelines using modern workflow management platforms, and publication of complex datasets with web-accelerated graphics.
In addition to direct bioinformatics support on a per-project basis, the Hutch Data Core offers training and documentation to enable scientist-driven computation. We also support automation of complex workflows for high-performance computing and provide access to web platforms specifically designed to meet researchers’ unique needs.

The Immune Monitoring shared resource supports investigators seeking precise evaluations of immunologic responses in both basic and early-stage clinical research settings. We provide users with resources and expertise to evaluate cellular immunologic processes and responses through reagents, molecular and cellular assays, assay development support and research-consulting services.

Provides in vivo imaging technology and infrastructure to support basic and preclinical research. Offers diverse array of imaging modalities, including ultrasound and optical imaging, MRI, micro-CT and multiphoton microscopy.

Provides support for mass spectrometry based proteomics and metabolomics research. With advanced instrumentation and highly trained staff, core offers consultation and services in sample preparation, sample separation, data collection and data analysis.

Supports development and maintenance of preclinical mouse models, including patient derived xenografts, cell line xenografts and genetically engineered mouse models.

The Genomics & Bioinformatics shared resource provides an integrated, streamlined and expertly supported set of services that encompass experimental design, data generation and data interpretation. Expert genomics and bioinformatics teams are available to consult and collaborate at every step of the process and work closely together to develop optimized experimental strategies to ensure that appropriate technology and data analysis tools are used to address each unique scientific question.

Provides biospecimen sample processing, extraction and biorepository services. Offers expertise to advance preclinical and clinical studies.