ZeBanC is an integrated healthcare biobank that operates under certified conditions and strict SOPs. This enables biomedical and translational researchers to perform their analyses using high-quality biospecimens and data to generate reliable and reproducible research data. To meet the needs of our various stakeholders, we offer a modular biobanking portfolio that can cover the entire workflow from blood collection to storage, including all pre-analytical steps and their documentation. This includes access to existing biospecimens and data under well-defined and agreed conditions. Furthermore, we offer a spectrum of additional services ranging from DNA/RNA extraction and virtual microscopy to the entire management of sample and data flow for national/international research consortia. Last but not least, we provide secure conventional and automated storage of samples at various temperatures as well as secure data management.

Two experimental 7 Tesla magnetic resonance imaging machines were purchased by the Center for Stroke Research CSB (Device 1) and the Cluster of Excellence NeuroCure
(Device 2) with the aim of creating an experimental platform for small animal imaging. The facilities will service projects in the areas of A) Experimental Neuroimaging and B) Molecular Imaging, but projects in other fields of research are explicity encouraged.
The Core Facility is available to all public research institutions and interested industrial partners.

Preclinical (mice, rats) Radionuclide Imaging with SPECT/CT and PET/MR, radiochemistry, tracer biokinetics and kinetic modeling

Transgenic Service providing
• Generation of transgenic mice via pronucleus injection (TALEN, CrispR Cas9) and ES-cell based techniques including ES-cell culture
• Cryopreservation of mice via Sperm and Embryos
• Rederivation
• De novo ES-cell establishment
• De novo establishment of Trophoblast cells

We are generating viral vectors for Charite members and external non-profit academic institutions.

The Core Facility offers thin sectioning, transmission electron microscopy (TEM), Cryo-TEM, confocal light microscopy and scanning electron microscopy (SEM). Advice is given routinely for adequate project programming. Projects are closely monitored during the course of evaluations by the core facility staff. The core facility is equipped with the necessary LM, TEM and SEM devices and a technical staff takes care of all the technical work. The director (Prof. Bachmann), vice director (Prof. Vida) and an additional technical assistant plus a photographer help to extend and control project work in the core facility.