Multi-center facility at Columbia University Irving Medical Center, created to help users take advantage of up-to-date resources in the stem cell field in a timely and cost-efficient way. Offered services include giving access to quality-controlled pluripotent stem cells and stem cell-derivatives prepared using standardized approaches; genome editing services for the generation of custom-designed cell lines; training sessions and informal interactions between scientists from multiple laboratories working on different stem cell models. Some reagents commonly used in stem cell labs, as mTeSR1 media and irradiated mouse embryonic fibroblasts, are also available at discounted prices for our users. We are connected to Stem Cell COREdinates(link is external and opens in a new window), a consortium of pluripotent stem cell-focused core facilities, which allows us to take advantage of the sharing of the most updated and efficient protocols, expertise, and reagents.

Advanced microscope systems for multidimensional optical imaging of living and fixed cells and tissues. Microscopy technologies include confocal, super-resolution (Airyscan and SMLM), TIRF, and wide-field microscopy as well as plate reading and laser capture microdissection. Analysis workstation and software are available, with custom pipeline development for processing, analysis, and visualization.

Provides access to imaging technology. Offers combination of both commercial platforms and not-yet commercialized technologies that enable innovative research centered around structural and functional imaging. Optical microscopy and image analysis platform.

Core provides investigators access to state-of-the-art vector technology for preclinical studies and other basic research applications.

Core makes available to Diabetes Research Center investigators variety of high quality radio-immunoassay, ELISA, and other analytical methods, and facilitates access of DRC investigators to measurement of small molecules by targeted and untargeted metabolomics/lipidomics with the Irving Institute Biomarkers Core. TBAC also provides consultations and services for in vivo methods to measure insulin secretion and sensitivity.

Core which assists investigators to quantify and phenotypically characterize cell populations that contribute to the metabolic, immunologic and developmental programs of diabetes and its complications; and to purify populations of cells of relevance to diabetes and its complications.

Core that provides services that facilitate the efficient characterization of mouse models of diabetes and its complications: NMR Body Composition Analysis, Whole Body Metabolic Assessment (chamber calorimetry with motion detection), Metabolic Clamps, Gastric Infusion/Feeding and Thermogenic Phenotyping.

Core that provides spectrum of advanced cellular and tissue pathology and imaging services for diabetes researchers at Columbia University. It also has microscopy equipment and services such as confocal, live 2-photon and scanning and transmission electron microscopy.

RARAF is dedicated to providing user-friendly radiation sources and bio-labs for research in biology, radiation biology, and radiation physics.

The Confocal and Specialized Microscopy Shared Resource provides advanced microscope systems for multidimensional optical imaging of living and fixed cells and tissues.
The facility offers a range of state-of-the-art microscopy technologies, including confocal, super-resolution (SIM and STORM), and wide-field microscopy as well as laser capture and microirradiation.
We also offer software and support for image processing, analysis, and presentation.

The focus of the Comparative Proteomics Center is the identification of proteins with differential occurrence in cells, tissues or in affinity purifications. We use two complementary techniques to compare different proteomes. The first is label-free shotgun protein profiling. Another technique called difference gel electrophoresis (DIGE)is also used. We are always interested in doing collaborative projects with research groups at other institutions. Please do not hesitate to contact us.