The University of Washington Mouse CRISPR Core (UWMCC) is a cost center administered through the Department of Comparative Medicine at the University of Washington (UW), Seattle, WA. The UWMCC is a full-service facility offering rapid, precise and economical generation of novel transgenic mouse models using CRISPR/Cas9 gene editing technology. Our standard service includes consultation, design, testing, prep, mouse embryo microinjection, and genotyping all at a competitive price point. The UWMCC is a joint collaboration utilizing 15 years of gene-editing experience by the UW Transgenic Resources Program, the UW Institute for Stem Cell and Regenerative Medicine, and the Vector and Transgenic Mouse Core of the UW Diabetes Research Center.

The Transgenic Resources Program (TRP) is a core facility that creates transgenic and gene-targeted mice using pronuclear microinjection, targeted ES cell microinjection, and CRISPR-Cas9 gene editing. The TRP also offers mouse rederivation services to create specific pathogen free mice or to revive cryopreserved mouse lines. Additionally, embryo and sperm cryopreservation services are available to provide long-term storage of valuable mouse strains or stocks. Our facility is available to all University of Washington investigators and outside institutions.

Magnetoencephalography facility focusing on children. Equipped with MEGIN TRIUX Neo system with helium recycler, MAGSTIM EEG data acquisition system, Tucker-Davis Technologies RZ6 for stimulus generation, Epson Home Cinema 3200 for video projection, custom video recording system with 4 cameras, Eyelink eyetracker, and Polhemus 3D digitizer.

The Preclinical Research and Translational Services (PRTS) Core at the University of Washington (UW) is a collection of individual core facilities that provide support for both internal (UW) and external (outside of UW) collaborators, researchers, and scientists.

Managed by the Department of Comparative Medicine, the PRTS Core provides in-life services including the Transgenic Resources Program (TRP), In Vivo Services (IVS), the Gnotobiotic Animal Core (GNAC), the Biosafety Level (BSL-3) Facility, and the Patient Derived Xenograft (PDX) Core, as well as pathology support by the Histology and Imaging Core (HIC) and the Comparative Pathology Program (CPP).

The Gnotobiotic Animal Core (GNAC) at the University of Washington (UW) is a core facility started in 2014 and managed by the Department of Comparative Medicine. Located in the UW Health Sciences Center, the GNAC is open to investigators with research needs to create or maintain mice free of any microorganisms (germ-free), or with a known population of microorganisms (gnotobiotic). Our facility is available to all University of Washington investigators as well as outside institutions.

The Histology and Imaging Core (HIC) provides histology, immunohistochemistry, imaging, quantitative image analysis, and pathology consultation services. We employ extensive experience, expertise and state of the art high-throughput instrumentation across all platforms in our facility. This core is open to all investigators, including; UW and their affiliates, commercial and not-for-profit biotechnology companies, and other academic institutions. Through our partnership with the Comparative Pathology Program (CPP) we have access to experienced comparative pathologists who are available for research consultation and collaboration.

The In Vivo Services (IVS) Core provides mouse colony management at the UW. IVS staff will oversee the maintenance, breeding, weaning, identification, and record keeping of your mouse colonies to free up the limited and valuable time of your laboratory personnel. In addition, the IVS Core offers an array of technical services performing procedures such as sample collection, sample administration, metabolic testing, behavioral assays, and testing of drug compounds in rodents. Our facility is available to all University of Washington investigators and outside institutions.