Sanford-Burnham Medical Research Institute
10901 N. Torrey Pines Rd.
La Jolla, CA 92037http://www.sanfordburnham.org/technology/sr/Pages/LaJolla_Crystallography.aspx
Jinghua Yu, Ph.D.
Last Updated: 08/20/2012
The X-ray Crystallography Facility is equipped with a Rigaku FR-E SuperBright Ultra high-intensity rotating anode generator, and utilizes both ports with two independent diffraction stations that can run simultaneously. Each station is equipped with an X-stream cryogenic system for standard low temperature (~100 K) data collection. The system is used to collect high resolution diffraction data from native and inhibitor-bound crystals or to test and optimize diffraction quality (cryo-protectant conditions, etc.) and screen for further data collection at synchrotron sources.
High throughput crystallization studies are supported by a Phoenix microdrop liquid handling system and Formulatrix incubators with automated image analysis for detecting crystal growth. This provides the ability to rapidly identify conditions to crystallize proteins or co-crystallize proteins with interacting compounds.
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