Johns Hopkins University
Barbara Daily
Johns Hopkins University
600 North Wolfe Street, Blalock 1032
Baltimore, MD 21287
http://grcf.jhmi.edu
RRID: RRID:SCR_018669
Advanced Analytical Technologies, Inc. FEMTO Pulse Fragment Analyzer
The Femtopulse is a fragment analyzer that provides a pulsed-field power supply which allows large molecular weight DNA fragments to be separated and nucleic acids detected into the femtogram range. The ability to separate high molecular weight DNA up to 165 kb and detect nucleic acids down to 50 fg per µL input concentration make the Femto Pulse system ideal for long-read NGS QC, gDNA, small RNA, or cfDNA analysis from low concentration samples. [Product Link]
RRID:SCR_018058
Applied Biosystems 3730xl Capillary Genetic Sequencer
The Applied Biosystems 3730xl is a 96-capillary DNA Analyzer that performs DNA fragment analysis applications such as microsatellites, AFLP, SNP analysis, mutation detection and traditional DNA sequencing. Get the highest quality data at a low cost per sample. Higher optical sensitivity and advanced polymers enable you to obtain higher-quality sequencing data for less. Multiple automation features decrease costly human errors. Optimized polymers increase your productivity without compromising your results. Perform a wide variety of sequencing and fragment analysis applications including resequencing, microsatellite analysis, AFLP, LOH, SSCP, SNP screening and SNP validation. [Product Link]
RRID:SCR_018059
Applied Biosystems 7900HT Fast Real-Time PCR System
The Applied Biosystems 7900HT is a real-time quantitative PCR system that combines 96- and 384-well plate compatibility and the TaqMan® Low Density Array with fully automated robotic loading-and now also offers optional Fast real-time PCR capability. The 7900HT System is a high-throughput real-time PCR system that detects and quantitates nucleic acid sequences. The Applied Biosystems 7900HT Fast Real-Time PCR System (7900HT Fast System) uses fluorescent-based PCR chemistries to provide: Quantitative detection of nucleic acid sequences using real-time analysis and Qualitative detection of nucleic acid sequences using end-point and dissociation-curve analysis. [Product Link]
RRID:SCR_018060
Hamilton StarPlus Automated Liquid Handler
Liquid handling robot with 8 channel pipetting arm, dual HEPA filter top, and 96 channel pipeting head with 1ml capacity. It can have tube racks, microplate racks, and 50mL temperature controlled tube rack. [Product Link]
RRID:SCR_018582
Life Technologies Countess Automated Cell Counter
Automated cell counter that can perform cell counts, viability calculations, hemocytometry, fluorescent protein expression, and measure fluorescence capabilities. There are also reusable slides, fluorescence capabilities, and brightfield fluorescence channels. [Product Link]
RRID:SCR_018591
Qiagen QIAcube DNA/RNA Protein Purification System
Protein purification system that performs fully automated purification of nucleic acids and proteins in molecular biology applications. [Product Link]
RRID:SCR_018618
Thermo Scientific Nanodrop 1000 Spectrophotometer
The Thermo Scientific NanoDrop™ 1000 is a spectrophotometer that performs measuring of 1 ul samples with high accuracy and reproducibility. The full spectrum (220nm-750nm) spectrophotometer utilizes a patented sample retention technology that employs surface tension alone to hold the sample in place. This eliminates the need for cumbersome cuvettes and other sample containment devices and allows for clean up in seconds. In addition, the NanoDrop 1000 Spectrophotometer has the capability to measure highly concentrated samples without dilution (50X higher concentration than the samples measured by a standard cuvette spectrophotometer). [Product Link]
RRID:SCR_018035
(Equipment No Longer Active At this Facility)
Illumina NovoSeq6000
QIAGEN QIAcuity dPCR system
Illumina iScan
DNA AnalyzerMycoDTect DNA-array (Greiner, Bio-One)
Illumina Genome Analyzer IIx
Formulatrix Constellation Digital PCR Instrument
Qiagen Pyromark Q48 pyrosequencer
Applied Biosystems QuantStudio 12Kflex
Qiagen QIAcuity Digital PCR instrument
Illumina NovaSeq6000
Illumina HiSeq2500
10x Genomics Chromium Platform
Taylor Warton LABS LN2 vapor phase freezer
MVE Vario LN2 vapor phase storage freezer
MVE High Efficiency LN2 vapor phase freezer
Applied Biosystems Veriti Thermocycler
Perkin Elmer MSM I DNA extractor
Integra Biosciences VIAFLO 96
Spectramax Gemini XS UV plate reader
Illumina Miseq
Oxford Nanopore GridION
Vi-Cell XR
Sorvall Legend STR Centrifuge
MicroCL21 Centrifuge
Nikon TMS Microscope
VWR Inverted Microscope
Forma Series II Water Jacketed CO2 Incubators
10x Genomics
Assay Development
Assays and Measurements
BioBanking
Biorepository
Bioshipping
Bisulfite Conversion
Blood Processing
Capillary Electrophoresis
CDNA Synthesis
Cell Culture
Cell Line Authentication
Cell Lines For SARS-CoV-2 Research
Central Laboratory Supply
ChIP-Seq
Clinical Trial Support
Consultations
Copy Number Variation (CNV)
Digital PCR
DNA Analysis
DNA Isolation
FFPE Na Isolation
FFPE Restore
Gene Expression Arrays
Genomics
Genotyping
Genotyping-by-sequencing
High Content Screening
Imputation
Long Read Sequencing
Methylation Analysis
Micro RNA Profiling
Microarray
Microbiome
Molecular Library Services
Mycoplasma Detection
Nanopore Sequencing
Non - Human Genotyping
Nucleic Acid Extraction
oligo synthesis
ONT Sequencing
OpenArray
PCR Arrays
Pyrosequencing
Real-time qPCR
Repository
RNA analysis
RNA Integrity
RNA Isolation
RNAseq
Sample Preparation
Sequencing - Capillary Sequencing
Sequencing - DNA Sequencing
Sequencing - Next Generation Sequencing (NGS)
Sequencing - Pyrosequencing
Single-cell Sequencing
Targeted Methylation Analysis
Tissue Culture
Whole Exome Sequencing
Whole Genome Amplification (WGA)
Whole Genome Arrays
Whole Genome Sequencing
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2.) Wilson JL, Akin E, Zhou R, Jedlicka A, Dziedzic A, Liu H, Fenstermacher KZJ, Rothman RE, Pekosz A (2023 Sep 20). The Influenza B Virus Victoria and Yamagata Lineages Display Distinct Cell Tropism and Infection-Induced Host Gene Expression in Human Nasal Epithelial Cell Cultures. Viruses, 15(9), . . PMID: 37766362.
3.) Yeung-Luk BH, Narayanan GA, Ghosh B, Wally A, Lee E, Mokaya M, Wankhade E, Zhang R, Lee B, Park B, Resnick J, Jedlicka A, Dziedzic A, Ramanathan M, Biswal S, Pekosz A, Sidhaye VK (2023 Aug 31). SARS-CoV-2 infection alters mitochondrial and cytoskeletal function in human respiratory epithelial cells mediated by expression of spike protein. mBio, 14(4), e0082023. . PMID: 37504520.
4.) Wilson JL, Akin E, Zhou R, Jedlicka A, Dziedzic A, Liu H, Fenstermacher KZ, Rothman R, Pekosz A (2023 Aug 4). The Influenza B Virus Victoria and Yamagata Lineages Display Distinct Cell Tropism and Infection Induced Host Gene Expression in Human Nasal Epithelial Cell Cultures bioRxiv, (), 2023.08.04.551980. . PMCID: 10418153.
5.) Wilson JL, Akin E, Zhou R, Jedlicka A, Dziedzic A, Liu H, Fenstermacher KZ, Rothman R, Pekosz A (2023 Aug 4). The Influenza B Virus Victoria and Yamagata Lineages Display Distinct Cell Tropism and Infection Induced Host Gene Expression in Human Nasal Epithelial Cell Cultures. bioRxiv : the preprint server for biology, (), . . PMID: 37577630.
6.) Resnick JD, Wilson JL, Anaya E, Conte A, Li M, Zhong W, Beer MA, Pekosz A (2023 Aug 2). Growth media affects susceptibility of air-lifted human nasal epithelial cell cultures to SARS-CoV2, but not Influenza A, virus infection bioRxiv, (), 2023.07.31.551381. . PMCID: 10418194.
7.) Resnick JD, Wilson JL, Anaya E, Conte A, Li M, Zhong W, Beer MA, Pekosz A (2023 Aug 2). Growth media affects susceptibility of air-lifted human nasal epithelial cell cultures to SARS-CoV2, but not Influenza A, virus infection. bioRxiv : the preprint server for biology, (), . . PMID: 37577692.
8.) Yeung-Luk BH, Narayanan GA, Ghosh B, Wally A, Lee E, Mokaya M, Wankhade E, Zhang R, Lee B, Park B, Resnick J, Jedlicka A, Dziedzic A, Ramanathan M, Biswal S, Pekosz A, Sidhaye VK (2023 Jul 28). SARS-CoV-2 infection alters mitochondrial and cytoskeletal function in human respiratory epithelial cells mediated by expression of spike protein mBio, 14(4), e00820-23. . PMCID: 10470579.
9.) Killian JT, King RG, Kizziah JL, Fucile CF, Diaz-Avalos R, Qiu S, Silva-Sanchez A, Mousseau BJ, Macon KJ, Callahan AR, Yang G, Hossain ME, Akther J, Houp JA, Rosenblum FD, Porrett PM, Ong SC, Kumar V, Saphire EO, Kearney JF, Randall TD, Rosenberg AF, Green TJ, Lund FE (2023 Jun 24). B cell and antibody targeting of transplant alloantigen epitopes is supported by both self and allo-recognition. bioRxiv : the preprint server for biology, (), . . PMID: 37034637.
10.) Resnick JD, Beer MA, Pekosz A (2023 Mar 18). Early Transcriptional Responses of Human Nasal Epithelial Cells to Infection with Influenza A and SARS-CoV-2 Virus Differ and Are Influenced by Physiological Temperature Pathogens, 12(3), 480. . PMCID: 10051809.
11.) Resnick JD, Beer MA, Pekosz A (2023 Mar 18). Early Transcriptional Responses of Human Nasal Epithelial Cells to Infection with Influenza A and SARS-CoV-2 Virus Differ and Are Influenced by Physiological Temperature. Pathogens (Basel, Switzerland), 12(3), . . PMID: 36986402.
12.) Resnick JD, Beer MA, Pekosz A (2023 Mar 9). Early transcriptional responses of human nasal epithelial cells to infection with Influenza A and SARS-CoV-2 virus differ and are influenced by physiological temperature bioRxiv, (), 2023.03.07.531609. . PMCID: 10028862.
13.) Resnick JD, Beer MA, Pekosz A (2023 Mar 9). Early transcriptional responses of human nasal epithelial cells to infection with Influenza A and SARS-CoV-2 virus differ and are influenced by physiological temperature. bioRxiv : the preprint server for biology, (), . . PMID: 36945583.
14.) Liu S, Fu H, Ray M, Heinsberg LW, Conley YP, Anderson CM, Hubel CA, Roberts JM, Jeyabalan A, Weeks DE, Schmella MJ (2023 Jan 26). A longitudinal epigenome-wide association study of preeclamptic and normotensive pregnancy Epigenetics communications, 3(1), 1. . PMCID: 10101051.
15.) Romero JC, Berlinicke C, Chow S, Duan Y, Wang Y, Chamling X, Smirnova L (2023 Jan 19). Oligodendrogenesis and myelination tracing in a CRISPR/Cas9-engineered brain microphysiological system Frontiers in Cellular Neuroscience, 16(), 1094291. . PMCID: 9893511.
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44.) Doyle AJ, Doyle JJ, Bessling SL, Maragh S, Lindsay ME, Schepers D, Gillis E, Mortier G, Homfray T, Sauls K, Norris RA, Huso ND, Leahy D, Mohr DW, Caulfield MJ, Scott AF, Destrée A, Hennekam RC, Arn PH, Curry CJ, Van Laer L, McCallion AS, Loeys BL, Dietz HC (2012 Nov). Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm. Nature genetics, 44(11), 1249-54. doi: 10.1111/1755-0998.13181. ID: 23023332.
45.) Arav-Boger R, Wojcik GL, Duggal P, Ingersoll RG, Beaty T, Pass RF, Yolken RH (2012 Mar 13). Polymorphisms in Toll-like receptor genes influence antibody responses to cytomegalovirus glycoprotein B vaccine. BMC research notes, 5(4), 140. doi: 10.1371/journal.pone.0034426. ID: 22414065.
46.) Wu T, Fallin MD, Shi M, Ruczinski I, Liang KY, Hetmanski JB, Wang H, Ingersoll RG, Huang S, Ye X, Wu-Chou YH, Chen PK, Jabs EW, Shi B, Redett R, Scott AF, Murray JC, Marazita ML, Munger RG, Beaty TH (2012 Feb). Evidence of gene-environment interaction for the RUNX2 gene and environmental tobacco smoke in controlling the risk of cleft lip with/without cleft palate. Birth defects research. Part A, Clinical and molecular teratology, 94(2), 76-83. doi: 10.1002/bdra.22885. ID: 22241686.
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The Genetic Resources Core Facility (GRCF)
A Part of the Johns Hopkins community for more than 30 years
A JHU service center which encompasses the Core Store, BioBank & Cell Center, and DNA Services. Collectively, these groups produce a number of products and services to aid researchers in performing studies in molecular biology and genetics.
JHU BioBank & Cell Center
Facilitates CAP-accredited clinical and basic scientific research by providing expertise and service in blood and biomaterial processing, mammalian cell culture, single-cell genomics, cryogenic storage, and national/international shipping.
DNA Services
Provides solutions for all of your DNA and RNA needs. We handle basic needs like DNA isolation, plating and storage, “traditional” core services like Sanger sequencing, PCR support and genotyping, and the more complex needs presented by the constantly changing field of next-generation sequencing.
