Geisel School of Medicine at Dartmouth
Contact Info:
Radu V Stan
1 Medical Center Drive
Lebanon, NH 03756
https://cancer.dartmouth.edu/scientists-researchers/irradiation-imaging-microscopy-animal-resource
Grants and Identifiers:
RRID: RRID:SCR_025077
Other Citation Identifiers5P30CA023108
Instrumentation:
Agilent/BioTek Cytation 5 imager with BioSpa 8 incubator
live cell high ththroughput imager for phase contrast and fluorescence
Akoya Vectra 3 automated slide scanning system
fluorescence and brightfield automated slide scanner with multispectral acquisition and spectral unmixing
Precision X-Irradiation X-RAD320
Irradiator for cells and whole animals, diagnostic x-ray and bioluminescence
Zeiss LSM 800 with Airyscan Confocal Laser Scanning Microscope
Confocal Laser Scanning Microscope with Airyscan
Services Provided:
3D & 4D Image Processing Stations
Brightfield Microscope With Axial Sectioning Capability
Clinical Imaging - Small Animal (luminescence/fluorescence)
Clinical Imaging - Small Animal (X-ray, Ultrasound, microCAT, MRI)
Confocal/ Super Resolution Microscope
Cryo-Electron Microscopy Of Vitrified Sections (CEMOVIS)
Cryo-Scanning Electron Microscopy
Differential Interference Contrast Microscopy
Fluorescence Microscope With Optical Sectioning Capability
Microstructure Characterization
Multiplexed Immunofluorescence
Transmission Electron Microscopy
Xenograft / Xenotransplantation
Relevant Publications:
Description:
The Irradiation, Imaging, Microscopy and Animal Cancer Models Shared Resource at Dartmouth Cancer center is an integrated resource offering services in Irradiation, pre-clinical imaging of small and large animals, light and electron microscopy as well as large and small animal cancer models. The Irradiation Section assists investigators in radiation treatment planning and delivery of ionizing irradiation to cells, rodents and large animals with engineered, transplanted or spontaneous tumors. The Imaging Section provides technologies for non-invasive, whole-animal imaging of animals used in preclinical research studies. The Microscopy Section provides access to point scanning confocal microscopy with Airyscan super resolution, conventional bright field and fluorescence light microscopy, high throughput live imaging, automated slide scanning and image analysis resources. The electron microscopy resource provides state of the art scanning , transmission and scanning transmission electron microscopy. The Animal Cancer Models section supports the generation and utilization of large and small animals for modeling cancer and other human diseases. The section has expertise in generating cancer models using wild type or genetically engineered animals in immunocompetent and immunocompromised backgrounds, as well as mice with a humanized immune system.
