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PHHL - Precision Human Health Laboratory

University of Alberta

Contact Info:

Eli Bok

8440 112st NW

Edmonton, AB T6G2R3

https://sites.google.com/ualberta.ca/phhl/home

Grants and Identifiers:

RRID: RRID:SCR_026314

Instrumentation:

Supine Ultrasound Bike

Supine position adjustable bike designed for stress echocardiography

ADInstruments Finapres Finometer MIDI (115V)

Continuous measurement of blood pressure using finger cuff and photoplethysmography.

ADInstruments Human NIBP System

The Human NIBP Nano monitoring system allows recording and measurement of a continuous blood pressure signal from an adult human via a non-invasive dual finger cuff system. The continuous blood pressure monitoring system contains the Human NIBP Nano Wrist Unit (Manufactured by Finapres Medical Systems), one Human NIBP Nano Height Correction Unit (HCU) and the Human NIBP Nano Interface (which both provides power to the Wrist Unit and facilitates communication with LabChart via USB).

ADInstruments Non Invasive Pulse Tonometer

Pulse Wave Tonometer enables simple, non-invasive assessment of the cardiovascular system by delivering high-fidelity blood pressure waveforms from direct skin contact with the carotid, femoral or radial artery.

ADInstruments PowerLab 16/35 & LabChart Pro

High frequency data acquisition system

(Equipment No Longer Active At this Facility)

Artinis Medical Oxymon MKIII

Continous-wave Near-infrared Spectroscopy

Artinis Medical Oxymon MKIII

Continous-wave near-infrared spectroscopy on biological tissue

BpTru Automatic blood pressure monitor

Automatic blood pressure and pulse measurement system using arm cuff

Cardinal Health Crash Cart Defibrillator

A crash cart defibrillator is a critical component of a crash cart (also known as a "code cart"), which is a specially equipped trolley used in hospitals for emergency resuscitation, especially in cases of cardiac arrest.

Cardinal Health Spirometer Microloop MK8

Portable human spirometry

COMPLIOR COMPLIOR Pulse-wave velocity machine

Non-invasive measurement of Pulse-wave velocity as an indicator of arterial stiffness. Measurement sites are carotid, radial, femoral and distal arteries

Covidien Pulse Oximeter

Human finger pulse oximetry works by emitting light from a pair of light-emitting diodes to measure the oxygen saturation level (SpO2)

D.E Hokanson Rapid Cuff Inflator

A Rapid Cuff Inflator is a device designed to quickly and efficiently inflate a blood pressure cuff or other similar medical devices. This tool is particularly useful in medical settings where time-sensitive measurements are needed, such as in operating rooms, intensive care units, or during certain diagnostic tests. Inflate up to 300mmHg

GE Healthcare Vivid E95 Cardiac Ultrasound

High-end diagnostic ultrasound with Doppler physics and instrumentation

GE Healthcare Vivid Q Cardiovascular ultrasound system

Portable cardiovascular ultrasound system

GMI HP 5890 series II gas chromatograph

Gas chromatography machine used for multiple inert gas elimination technique

Hans Rudolph Heated Pneumotachometer

The heating element in the pneumotach is designed to maintain a constant temperature, thus preventing condensation and ensuring consistent measurements during exercise.

Innovision INNOCOR Portable CO+CPX+NIBP System

Comprehensive diagnostic tool for measuring hemodynamic, metabolic and respiratory parameters

Itamar Medical EndoPAT2000

Non-invasive measurement of human endothelial function using finger cuffs

Koven SMARTDOP®X Bidirectional Doppler system

Fully Automatic Arterial Doppler system with foot skin temperature probe, and 14 cuff ports for simultaneous pressures. Venous Reflux capabilities.

Multigon Industry Neurovision Transcranial Doppler

Allows measurement of blood flow velocities in the intracranial vessels.

ResMed Sleep Apnea Recorder

Portable diagnostic tool for sleep apnea

Roxon Load MRI Ergometer

MRI-safe electronically-braked ergometer allowing Cycling/push/pull/up/down motion

Vacumed O2 and CO2 analyzer

This precision analyzer has a range from 0 to 100% with analog voltage output that can be connected to PowerLab system. Approx. 150 milli-seconds. Flow rate of 400ml/min

VWR International Revco Biological Sample Freezer

Ultra-low temepreature freezer for biological samples. 24.1 cu ft. 278 lbs. of cargo. 10 racks

Services Provided:

Analysis Workstations

Biochemical Analysis

Clinical Assessment (Hematology, Clinical Chemistries, etc.)

Clinical Research

Clinical Research Coordination/Scheduling

Clinical Trial Support

Physical Activity Assessment

Ultrasonic Imaging

Relevant Publications:

Description:

The Precision Human Health Laboratory (PHHL) is a specialized collaborative research facility at the University of Alberta, Canada. Our group adopts a multidisciplinary approach to advance the understanding of the three aims. Aim 1. Understand the mechanism(s) of vascular dysfunction in chronic disease Aim 2. Identify how vascular dysfunction contributes to exercise intolerance Aim 3. Evaluate how exercise training improves vascular dysfunction and exercise intolerance using innovative clinical trial designs. These common aims will be examined by the principal investigators across three patient groups (respiratory, cancer, chronic kidney disease). Dr. M. Stickland is a Professor of Medicine with expertise in cardiopulmonary physiology and exercise. His research program includes examining: 1. Cardiovascular complications of respiratory disease, 2. Vascular regulation, 3. Dyspnea and exercise intolerance in cardiopulmonary disease, 4. Pulmonary rehabilitation and disease management. Dr. Pituskin is an Associate Professor, Tier 2 Canada Research Chair, and a pioneer in cardio-oncology. Her research program demonstrates sequential development of high-priority knowledge aiming to better understand and holistically address the multifactorial interplay of individual physiology, treatment-related physiologic impacts, informative biomarkers and patient experience. Dr. Thompson is an Assistant Professor and Nephrologist with a developing research program using exercise as therapeutic strategy for the prevention of adverse CV outcomes in people with CKD. She is an early career investigator and obtained CIHR funding to examine the effect of exercise on hypertension and CV risk in CKD. The PHHL builds on Dr. Stickland’s highly successful 2013 CFI grant (#30732) which enabled several CIHR and NSERC grants, >50 publications from Dr. Stickland’s team and >15 publications from Drs. Pituskin, Thompson, and collaborators