Pennsylvania State University

Contact Info:

Neela Yennawar

https://www.huck.psu.edu/core-facilities/automated-biological-calorimetry-facility

Grants and Identifiers:

RRID: RRID:SCR_024458

Instrumentation:

Services Provided:

Relevant Publications:

1.) Zhang H, Yao Y, Wang X, Zheng Y, Zhang S, Tao Y, Yang H, Wang Y, Liu M, Feric M, Zhou R (2026 Mar 9). FLEXTAG: a small and self-renewable protein labeling system for anti-fading multi-color super-resolution imaging. Nature communications, 17(1), . . PMCID: 12972069.

2.) Sieg J, Zeng H, Pálová H, Smeds L, Mohanty S, Lahnsteiner A, Chiaromonte F, Makova KD (2025 Nov 4). Comparative analysis of single-stranded and non-canonical DNA formation in human and other ape cells with telomere-to-telomere genomes bioRxiv, (), 2025.11.03.686349. . PMCID: 12637528.

Description:

Automated Biological Calorimetry Facility provides infrastructure and support for individual investigators to undertake studies of macromolecule binding and folding, as well as protein and lipid quantification. Our calorimetry instruments are fully automated and require the least amount of sample of any commercially available instruments.Provides instrumentation and collaborative assistance for Isothermal titration calorimetry for studying ligand-macromolecule binding; Differential scanning calorimetry for investigating stability and folding thermodynamics. Staff is available to assist with project development and research.