Oregon Health & Science University
Robert Searles
L581
3181 Sam Jackson Park Rd
Portland, OR 97239
https://www.ohsu.edu/integrated-genomics-laboratory
RRID: RRID:SCR_022651
See www.ohsu.edu/gpsr, www.ohsu.edu/mpssr, and www.ohsu.edu/dnaseq for a listing of major equipment.
10x Genomics
Cell Line Authentication
CITE-seq
Consultations
Copy Number Variation (CNV)
DNA Analysis
DNA Isolation
Genomics
Genotyping
Nanostring NCounter
Nucleic Acid Extraction
Outreach
PCR Arrays
Real-time qPCR
RNA analysis
RNA Integrity
RNA Isolation
RNAseq
Sequencing - DNA Sequencing
Sequencing - Next Generation Sequencing (NGS)
Single-Cell Analysis
Single-cell Sequencing
TaqMan Arrays
Training
Whole Exome Sequencing
Whole Genome Sequencing
1.) Methner C, Le DE, Liu L, Plascencia M, Kajimoto M, Thompson A, Cianciulli A, Pellacani A, Micheli F, Kaul S (2026 Jan 20). Selective Pharmacological Blockade of GPR39 Markedly Reduces No Reflow and Infarct Volumes in a Rat Model of Acute Myocardial Infarction. bioRxiv : the preprint server for biology, (), . . PMCID: 12871670.
2.) Hill RZ, Nelson JW, Gyarmati G, Medrano S, Shirvan S, McCormick JA, Burquez S, Ahmed J, Eng DG, Wysocki J, Dubin AE, Servin-Vences MR, Lakshmanan A, Gomez RA, Sequeira-Lopez MLS, Shankland SJ, Batlle D, Miner JH, Peti-Peterdi J, Patapoutian A (2026 Jan 8). Renal PIEZO2 is an essential regulator of renin. Cell, 189(1), 161-178.e22. . PMCID: 12695021.
3.) Minko IG, Vartanian VL, Luzadder MM, Wang Y, Fedorov LM, McCullough AK, Lloyd RS (2025 Apr). Aflatoxin B(1)-Induced Hepatic Mutagenesis in Mice Expressing Gene-Edited Neil1. Environmental and molecular mutagenesis, 66(4), 144-154. . PMID: 40342069.
4.) Luzadder MM, Minko IG, Vartanian VL, Davenport M, Fedorov LM, McCullough AK, Stephen Lloyd R (2025 Jan 2). The distinct roles of NEIL1 and XPA in limiting aflatoxin B1-induced mutagenesis in mice Molecular cancer research : MCR, 23(1), 46-58. . PMCID: 11695181.
5.) Luzadder MM, Minko IG, Vartanian VL, Davenport M, Fedorov LM, McCullough AK, Lloyd RS (2025 Jan 2). The Distinct Roles of NEIL1 and XPA in Limiting Aflatoxin B1-Induced Mutagenesis in Mice. Molecular cancer research : MCR, 23(1), 46-58. . PMID: 39387543.
6.) Minko IG, Luzadder MM, Vartanian VL, Rice SPM, Nguyen MM, Sanchez-Contreras M, Van P, Kennedy SR, McCullough AK, Lloyd RS (2024 Apr). Frequencies and spectra of aflatoxin B(1)-induced mutations in liver genomes of NEIL1-deficient mice as revealed by duplex sequencing. NAR molecular medicine, 1(2), ugae006. . PMID: 38779538.
7.) Su XT, Reyes JV, Lackey AE, Demirci H, Bachmann S, Maeoka Y, Cornelius RJ, McCormick JA, Yang CL, Jung HJ, Welling PA, Nelson JW, Ellison DH (2024 Jan 19). Enriched Single-Nucleus RNA-Sequencing Reveals Unique Attributes of Distal Convoluted Tubule Cells Journal of the American Society of Nephrology : JASN, 35(4), 426-440. . PMCID: 11000721.
The Integrated Genomics Lab (IGL) provides a range of genomics services. These include nucleic acid isolation, qPCR, and sequencing library preparation for bulk RNA and DNA and for single-cell RNA-seq using the 10x Genomics Chromium iX. Sequencing is done using either a NovaSeq 6000 or a NextSeq 2000. The IGL also offers alignment of bulk RNA sequencing data and single-cell RNA-seq data. In addition, the IGL provides an oligonucleotide ordering service through IDT and a cell line authentication service.
