University of Arizona

Contact Info:

Marloes Van Den Berg

1656 E Mabel St

Medical Research Building 340

Tucson, AZ 85724

https://research.arizona.edu/university-arizona-phenotyping-core-uapc

Grants and Identifiers:

RRID: RRID:SCR_023879

Instrumentation:

Services Provided:

Relevant Publications:

1.) Methawasin M, Meinke S, Radke MH, Farman GP, Hourani Z, Smith JE 3rd, Guo W, Granzier H, Gotthardt M (2025 Oct 28). Rbm20 antisense oligonucleotides alleviate diastolic dysfunction in a mouse model of cardiometabolic heart failure (HFpEF). Cardiovascular research, 121(13), 2027-2041. . PMCID: 12560776.

2.) Methawasin M, Zhang Y, Gregorich ZR, He Y, Liu C, Muldoon J, Hourani Z, Smith JE 3rd, Granzier H, Guo W (2025 May 9). Reducing Granules Without Splicing Restoration Alleviates RBM20 Cardiomyopathy. Circulation research, 136(10), 1134-1146. . PMCID: 12064375.

3.) Methawasin M, Strom J, Marino VA, Gohlke J, Muldoon J, Herrick SR, van der Pijl R, Konhilas JP, Granzier H (2025 Apr 1). An ovary-intact postmenopausal HFpEF mouse model; menopause is more than just estrogen deficiency. American journal of physiology. Heart and circulatory physiology, 328(4), H719-H733. . PMID: 39963865.

4.) Strom J, Bull M, Gohlke J, Saripalli C, Methawasin M, Gotthardt M, Granzier H (2024 Jun). Titin's cardiac-specific N2B element is critical to mechanotransduction during volume overload of the heart. Journal of molecular and cellular cardiology, 191(), 40-49. . PMID: 38604403.

5.) Thota LN, Lopez Rosales JE, Placencia I, Zemskov EA, Tonino P, Michael AN, Black SM, Chignalia AZ (2023 Sep 26). The Pulmonary Endothelial Glycocalyx Modifications in Glypican 1 Knockout Mice Do Not Affect Lung Endothelial Function in Physiological Conditions International Journal of Molecular Sciences, 24(19), 14568. . PMCID: 10573009.

Description:

The University of Arizona Phenotyping Core (UAPC) provides a variety of services to assist researchers with phenotyping of small laboratory animals (mice, rats, guinea pigs, rabbits) with a focus on cardiovascular- neuromuscular-, and respiratory function, and exercise tolerance. Services: 1. Experiments: we perform experiments (i.e., cardiovascular ultrasound, plethysmography, exercise studies), small animal surgeries (i.e., LAD-ligation, transaortic constriction), and data analysis for you. 2. Training: we help you master new equipment, small animal surgeries or data analysis. 3. Equipment rent: we offer a wide range of up-to-date equipment to measure cardiovascular-, neuromuscular-, respiratory function, and exercise tolerance. 4. Consultation: we advice you on experimental design, (physiological) data-collection, analysis, interpretation and IACUC protocols, grant- and manuscript writing. 5. Other requests? Please contact us!