Cancer Research UK Beatson Institute
Claire Mitchell
Switchback Road
Glasgow
https://www.crukscotlandinstitute.ac.uk/advanced-technologies/bair.html
RRID: RRID:SCR_023875
3D & 4D Image Processing Stations
3D Printing
3D Visualization
Analysis Workstations
Assay Development
Assays and Measurements
Bioimage Informatics
Brightfield Microscopy
Cell Imaging
Confocal Microscopy
Confocal/ Super Resolution Microscope
Data Analysis
Data Analysis And Interpretation
Data Processing
Data Processing And Interpretation
Data Visualization
Deconvolution
Differential Interference Contrast Microscopy
Experimental Design
Fluorescence Lifetime
Fluorescence Microscope With Optical Sectioning Capability
Forster Resonance Energy Transfer (FRET)
High Content Screening
Image Aquisition
Image Data Management
Image Processing And Analysis
Immunofluorescence
In-vivo Imaging
Laser Capture Microdissection
Light-sheet Microscopy
Live Cell Imaging
Microscopy
Multiphoton Microscopy
Multiphoton/ Harmonic Generation Microscope
Optical Imaging
Outreach
Phase Contrast Microscopy
Sample Preparation
Spinning Disk Confocal Imaging
Stereomicroscopy
TIRF Microscopy
Tissue Culture
Widefield Microscopy
1.) Thomason PA, Corbyn R, Lilla S, Sumpton D, Gilbey T, Insall RH (2024 Aug 5). Biogenesis of lysosome-related organelles complex-2 is an evolutionarily ancient proto-coatomer complex. Current biology : CB, 34(15), 3564-3581.e6. doi: 10.1016/j.cub.2024.06.081. ID: 39059394.
2.) Mandrou E, Thomason PA, Paschke PI, Paul NR, Tweedy L, Insall RH (2024 Jun 27). A Reliable System for Quantitative G-Protein Activation Imaging in Cancer Cells. Cells, 13(13), . . ID: 38994966.
3.) Matchett KP, Wilson-Kanamori JR, Portman JR, Kapourani CA, Fercoq F, May S, Zajdel E, Beltran M, Sutherland EF, Mackey JBG, Brice M, Wilson GC, Wallace SJ, Kitto L, Younger NT, Dobie R, Mole DJ, Oniscu GC, Wigmore SJ, Ramachandran P, Vallejos CA, Carragher NO, Saeidinejad MM, Quaglia A, Jalan R, Simpson KJ, Kendall TJ, Rule JA, Lee WM, Hoare M, Weston CJ, Marioni JC, Teichmann SA, Bird TG, Carlin LM, Henderson NC (2024 Jun). Multimodal decoding of human liver regeneration. Nature, 630(8015), 158-165. . ID: 38693268.
4.) Derby SJ, Dutton L, Strathdee KE, Stevenson K, Koessinger A, Jackson M, Tian Y, Yu W, Mclay K, Misquitta J, Alsharif S, Clarke CJ, Gilmour L, Thomason P, McGhee E, McGarrity-Cottrell CL, Vanderlinden A, Collis SJ, Rominyi O, Lemgruber L, Solecki G, Olson M, Winkler F, Carlin LM, Heiland DH, Inman GJ, Chalmers AJ, Norman JC, Carruthers R, Birch JL (2024 Apr 5). Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalization via macropinocytosis. Neuro-oncology, 26(4), 625-639. . ID: 37936324.
5.) Santi A, Kay EJ, Neilson LJ, McGarry L, Lilla S, Mullin M, Paul NR, Fercoq F, Koulouras G, Rodriguez Blanco G, Athineos D, Mason S, Hughes M, Thomson G, Kieffer Y, Nixon C, Blyth K, Mechta-Grigoriou F, Carlin LM, Zanivan S (2024 Mar 12). Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function. Science signaling, 17(827), eade0580. doi: 10.1126/scisignal.ade0580. ID: 38470957.
6.) Vringer E, Heilig R, Riley JS, Black A, Cloix C, Skalka G, Montes-Gómez AE, Aguado A, Lilla S, Walczak H, Gyrd-Hansen M, Murphy DJ, Huang DT, Zanivan S, Tait SW (2024 Mar). Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. The EMBO journal, 43(6), 904-930. . ID: 38337057.
7.) Papalazarou V, Newman AC, Huerta-Uribe A, Legrave NM, Falcone M, Zhang T, McGarry L, Athineos D, Shanks E, Blyth K, Vousden KH, Maddocks ODK (2023 Dec). Phenotypic profiling of solute carriers characterizes serine transport in cancer. Nature metabolism, 5(12), 2148-2168. . ID: 38066114.
8.) Hewitt RJ, Puttur F, Gaboriau DCA, Fercoq F, Fresquet M, Traves WJ, Yates LL, Walker SA, Molyneaux PL, Kemp SV, Nicholson AG, Rice A, Roberts E, Lennon R, Carlin LM, Byrne AJ, Maher TM, Lloyd CM (2023 Sep 27). Lung extracellular matrix modulates KRT5(+) basal cell activity in pulmonary fibrosis. Nature communications, 14(1), 6039. . ID: 37758700.
9.) Grotehans N, McGarry L, Nolte H, Xavier V, Kroker M, Narbona-Pérez ÁJ, Deshwal S, Giavalisco P, Langer T, MacVicar T (2023 Sep 18). Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression. The EMBO journal, 42(18), e113256. . ID: 37439264.
10.) Nikolatou K, Sandilands E, Román-Fernández A, Cumming EM, Freckmann E, Lilla S, Buetow L, McGarry L, Neilson M, Shaw R, Strachan D, Miller C, Huang DT, McNeish IA, Norman JC, Zanivan S, Bryant DM (2023 Sep 18). PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer. The EMBO journal, 42(18), e113987. . ID: 37577760.
11.) Vande Voorde J, Steven RT, Najumudeen AK, Ford CA, Dexter A, Gonzalez-Fernandez A, Nikula CJ, Xiang Y, Ford L, Maneta Stavrakaki S, Gilroy K, Zeiger LB, Pennel K, Hatthakarnkul P, Elia EA, Nasif A, Murta T, Manoli E, Mason S, Gillespie M, Lannagan TRM, Vlahov N, Ridgway RA, Nixon C, Raven A, Mills M, Athineos D, Kanellos G, Nourse C, Gay DM, Hughes M, Burton A, Yan B, Sellers K, Wu V, De Ridder K, Shokry E, Huerta Uribe A, Clark W, Clark G, Kirschner K, Thienpont B, Li VSW, Maddocks ODK, Barry S (2023 Aug). Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target. Nature metabolism, 5(8), 1303-1318. . ID: 37580540.
12.) Whyte D, Skalka G, Walsh P, Wilczynska A, Paul NR, Mitchell C, Nixon C, Clarke W, Bushell M, Morton JP, Murphy DJ, Muthalagu N (2023 Jul). NUAK1 governs centrosome replication in pancreatic cancer via MYPT1/PP1β and GSK3β-dependent regulation of PLK4. Molecular oncology, 17(7), 1212-1227. . ID: 36975767.
13.) Abrams B, Pengo T, Wee TL, Deagle RC, Vuillemin N, Callahan LM, Smith MA, Kubow KE, Girard AM, Rappoport JZ, Bayles CJ, Cameron LA, Cole R, Brown CM (2023 Apr 5). Tissue-Like 3D Standard and Protocols for Microscope Quality Management. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 29(2), 616-634. . ID: 37749742.
14.) Sandilands E, Freckmann EC, Cumming EM, Román-Fernández A, McGarry L, Anand J, Galbraith L, Mason S, Patel R, Nixon C, Cartwright J, Leung HY, Blyth K, Bryant DM (2023 Apr 3). The small GTPase ARF3 controls invasion modality and metastasis by regulating N-cadherin levels. The Journal of cell biology, 222(4), . . ID: 36880595.
15.) Schmidt T, Dabrowska A, Waldron JA, Hodge K, Koulouras G, Gabrielsen M, Munro J, Tack DC, Harris G, McGhee E, Scott D, Carlin LM, Huang D, Le Quesne J, Zanivan S, Wilczynska A, Bushell M (2023 Feb 28). eIF4A1-dependent mRNAs employ purine-rich 5 Nucleic acids research, 51(4), 1859-1879. . ID: 36727461.
16.) Román-Fernández A, Mansour MA, Kugeratski FG, Anand J, Sandilands E, Galbraith L, Rakovic K, Freckmann EC, Cumming EM, Park J, Nikolatou K, Lilla S, Shaw R, Strachan D, Mason S, Patel R, McGarry L, Katoch A, Campbell KJ, Nixon C, Miller CJ, Leung HY, Le Quesne J, Norman JC, Zanivan S, Blyth K, Bryant DM (2023 Feb 3). Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Science advances, 9(5), eabq1858. . ID: 36735782.
17.) Freckmann EC, Sandilands E, Cumming E, Neilson M, Román-Fernández A, Nikolatou K, Nacke M, Lannagan TRM, Hedley A, Strachan D, Salji M, Morton JP, McGarry L, Leung HY, Sansom OJ, Miller CJ, Bryant DM (2022 Sep 9). Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging. Nature communications, 13(1), 5317. . ID: 36085324.
18.) Le AH, Yelland T, Paul NR, Fort L, Nikolaou S, Ismail S, Machesky LM (2021 Sep 6). CYRI-A limits invasive migration through macropinosome formation and integrin uptake regulation. The Journal of cell biology, 220(9), . . ID: 34165494.
19.) Yelland T, Garcia E, Samarakoon Y, Ismail S (2021 Jun 15). The Structural and Biochemical Characterization of UNC119B Cargo Binding and Release Mechanisms. Biochemistry, 60(25), 1952-63. . ID: 34130453.
20.) Nacke M, Sandilands E, Nikolatou K, Román-Fernández Á, Mason S, Patel R, Lilla S, Yelland T, Galbraith LCA, Freckmann EC, McGarry L, Morton JP, Shanks E, Leung HY, Markert E, Ismail S, Zanivan S, Blyth K, Bryant DM (2021 Mar 12). An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. Nature communications, 12(1), 1623. . ID: 33712589.
21.) Yelland T, Le AH, Nikolaou S, Insall R, Machesky L, Ismail S (2021 Mar 4). Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1. Structure (London, England : 1993), 29(3), 226-237.e4. . ID: 33217330.
22.) Pickering KA, Gilroy K, Cassidy JW, Fey SK, Najumudeen AK, Zeiger LB, Vincent DF, Gay DM, Johansson J, Fordham RP, Miller B, Clark W, Hedley A, Unal EB, Kiel C, McGhee E, Machesky LM, Nixon C, Johnsson AE, Bain M, Strathdee D, van Hoof SR, Medema JP, Anderson KI, Brachmann SM, Stucke VM, Malliri A, Drysdale M, Turner M, Serrano L, Myant K, Campbell AD, Sansom OJ (2021 Jan 4). A RAC-GEF network critical for early intestinal tumourigenesis. Nature communications, 12(1), 56. . ID: 33397922.
23.) Román-Fernández Á, Roignot J, Sandilands E, Nacke M, Mansour MA, McGarry L, Shanks E, Mostov KE, Bryant DM (2018 Nov 28). The phospholipid PI(3,4)P(2) is an apical identity determinant. Nature communications, 9(1), 5041. . ID: 30487552.
24.) Reid SE, Kay EJ, Neilson LJ, Henze AT, Serneels J, McGhee EJ, Dhayade S, Nixon C, Mackey JB, Santi A, Swaminathan K, Athineos D, Papalazarou V, Patella F, Román-Fernández Á, ElMaghloob Y, Hernandez-Fernaud JR, Adams RH, Ismail S, Bryant DM, Salmeron-Sanchez M, Machesky LM, Carlin LM, Blyth K, Mazzone M, Zanivan S (2017 Aug 15). Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. The EMBO journal, 36(16), 2373-2389. . ID: 28694244.
Beatson Advanced Imaging Resource scientists work closely with researchers to uncover and interrogate important molecular pathways in cancer. We train scientists in all stages of modern microscopical research from advice on experimental design and sample preparation, basic and advanced microscope operation and data acquisition through to quantitative image analysis and interpretation.
