Institut de Génomique Fonctionnelle
Contact Info:
Damien Maurel
c/o IGF, 141 rue de la Cardonille
Montpellier 34090
Grants and Identifiers:
RRID: RRID:SCR_023092
Instrumentation:
Services Provided:
Relevant Publications:
Description:
ARPEGE is specialized in the functional and structural analysis of protein complexes. This facility offers the possibility to characterize all types of molecular interactions: ligand-target binding, protein-protein interactions, signal transduction, and signalling complexes. The facility staff members are skilled specialists in luminescence-based techniques and in receptor biology. Application portfolio: - Analysis of cell signalling, by measuring signal transduction, - Ligand-target binding (pharmacological analysis, affinity, selectivity), - Protein-protein interactions (oligomerization, effectors...), - Activation of signalling pathways (G proteins, GRK, arrestins & internalization), - Intracellular production of second messengers (cAMP, IP1, Ca2+), - Phosphorylation of signalling proteins (ERK, AKT...), - Measurement of global cell functions and of different cell parameters (proliferation, migration, invasion...).
