Medical College of Wisconsin
Dr. Angela Mathison
8701 Watertown Plank Rd.
HRC 5th Floor
Milwaukee, WI 53226
https://www.mcw.edu/departments/genomic-sciences-and-precision-medicine-center-gspmc
RRID: RRID:SCR_022926
Agilent 5200 Fragment Analyzer System
Fragment Analyzer System allows you to separate 12 samples in parallel in as little as 15 minutes. [Product Link]
RRID:SCR_019417
BioTek Synergy LX Multi-Mode Microplate Reader
Microplate reader with an optic design that provides accurate data in absorbance, fluorescence and luminescence detection modes, enabling many common assays including nucleic acid and protein quantification, ELISA, BCA, Bradford and cell viability. [Product Link]
RRID:SCR_019763
Eppendorf 5430R Microcentrifuge
Cross-over Centrifuge 5430 and 5430 R combine the best features of a microcentrifuge (small footprint) and multipurpose centrifuge (versatility) in one instrument. These centrifuges spin rotors for Eppendorf tubes and PCR strips as you would expect from any microcentrifuge. But that's not all. In a compact size, Centrifuge 5430 and 5430 R also accommodate rotors for microplates and 15/50 mL conical tubes. Now, the rotor program has been expanded with additional Eppendorf QuickLock rotors. This includes 48-place rotors (1.5/2.0 mL), a 16-place rotor for Eppendorf Tubes 5.0 mL and a swing-bucket rotor (24 × 1.5/2.0 mL). With their unmatched versatility, Centrifuge 5430 and Centrifuge 5430 R are the flagship products among the Eppendorf microcentrifuge portfolio. Available as keypad or knob variant [Product Link]
RRID:SCR_019849
Illumina MiSeq System
Access focused applications such as targeted resequencing, metagenomics, small genome sequencing, targeted gene expression profiling, and more. MiSeq reagents enable up to 15 Gb of output with 25 million sequencing reads and 2 × 300 bp read lengths. [Product Link]
RRID:SCR_020134
Illumina NovaSeq 6000 Sequencing System
Unleashes groundbreaking innovations that leverage our technology Now you can get scalable throughput and flexibility for virtually any sequencing method, genome, and scale of project. [Product Link]
RRID:SCR_020150
(Equipment No Longer Active At this Facility)
Maxwell 16 DNA purification system
Nucleic Acid and Protein Purification instrument that provides consistent, automated purification of high-quality DNA, RNA, viral total nucleic acid, or recombinant proteins using paramagnetic particles. There are no Clogs or Drips, Optimal Capture, Washing, and Elution of Target Material, Purifier Can Configure as an SEV or LEV Instrument, Preprogrammed Purification Protocols, For Purification of High-Quality DNA, RNA, and More. It works as a particle processor, not a liquid handler, so there are no clogs or drips, allowing optimal capture, washing, and elution of target material. Purification protocols are preprogrammed into the instrument and can be combined with purification kits containing prefilled reagent cartridges to maximize simplicity and convenience. The purifier can be configured as an SEV Instrument (Standard Elution Volume, 200 400 ?L) for maximum yield or an LEV Instrument (Low Elution Volume, 30 100 ?L) for maximum concentration. Accessories information: Kits are sold separately and contain enough materials to run 48 preps each. [Product Link]
RRID:SCR_020254
Miltenyi gentleMACS Octo Dissociator with Heaters Tissue Dissociator
Benchtop instrument for fully automated and standardized tissue dissociation or homogenization of up to eight samples. Equipped with eight individual heating units and gentleMACS Programs. [Product Link]
RRID:SCR_020271
Perkin Elmer Chemagic 360 Genetic isolation Workstation
Nucleic Acid Extractor for Medium to High Throughput. Based on our patented chemagen magnetic bead technology the chemagic 360 instrument represents the best solution for nucleic acid isolation in a huge variety of research market segments including but not limited to Biobanking/Human Genetics, HLA Typing, Virus and Bacteria Detection. Experience the revolutionary compact benchtop design of our newly developed chemagic 360 Nucleic Acid Extractor. Based on the well-established chemagen Technology, the system offers a flexible solution for different sample processing and throughput needs. Configurable with three kinds of chemagic Rod Heads (see table below) the system can process sample volumes from 10 ?l 10 ml. [Product Link]
RRID:SCR_020394
Perkin Elmer Zephy G3 NGS liquid handler
Benchtop liquid handler designed to automate construction of 48 to 96 next generation sequencing libraries per day. [Product Link]
RRID:SCR_018616
Qiagen Tissue Lyser II RNA/DNA Purification
RNA and DNA purification analyzer that disrupts biological samples through high speed shaking in plastic tubes with stainless steel, tungsten carbide, or glass beads. [Product Link]
RRID:SCR_018623
Sage Science BluePippin system
Used for DNA Size Selection for Next-Gen Sequencing, with Pulsed-Field (100bp ? 50kb).BluePippin has the DNA capabilities of the Pippin Prep, plus the extra benefit of pulsed-field electrophoresis for resolving and collecting high molecular weight DNA. For long-range genomic applications, high-pass filtering allows users to collect all fragments above a size threshold set by the user. Target sizes or ranges of sizes are entered in software, and fractions are collected in buffer. Up to 5 samples/gel cassette may be run, with no possibility of cross contamination. [Product Link]
RRID:SCR_020505
(Equipment No Longer Active At this Facility)
Thermo Fisher Qubit 2.0 Fluorometer Qubit 2.0
Invitrogen Qubit Flex Fluorometer can selectively, accurately measure the concentration of up to 8 samples of DNA, RNA or protein simultaneously. Compared to single sample microvolume fluorometers, using the Qubit Flex Fluorometer for multiple samples reduces your time to data by up to 50%, with time savings beginning with batches of as few as 8 samples. Combining the one-of-a-kind Qubit Flex Fluorometer and optimized Invitrogen Qubit reagents and tube strips offers a complete solution for DNA, RNA and protein quantification. [Product Link]
RRID:SCR_020553
10X Genomics Chromium
Single Cell Sequencing
10X Genomics CytAssist
Spatial Biology
Bio-Rad Opus 384
Real Time PCR Instrument
Diagenode BioRuptor Nano
Chromatin/DNA Shearing
(Equipment No Longer Active At this Facility)
Diagenode BioRuptor Pico
Chromatic/DNA Shearing
(Equipment No Longer Active At this Facility)
Diagenode BioRuptor Plus
Chromatic/DNA Shearing
Diagenode BioRuptor Plus
Chromatin/DNA Shearing
Diagenode IP Star (SX-8G Compact)
Liquid Handling Robot
Eppendorf 5910 Ri
Centrifuge
Logos Biosystems Luna-FL
Cell Counter
NanoString nCounter
Gene Expression
Pacific Biosciences Sequel
Long Read Sequencer
(Equipment No Longer Active At this Facility)
Perkin Elmer SciClone
Liquid Handling Robot
Perkin Elmer SciClone G3 NGS
Liquid Handling Robot
Promega Maxwell RSC
Nucleic Acid Extraction
Thermo Fischer Scientific EVOS XL Core Imaging System
Microscope
10x Genomics
ATAC-Seq
ChIP-Seq
Data Analysis And Interpretation
Data Processing And Interpretation
Genome/Transcriptome Assembly And Annotation
Genomics
Long Read Sequencing
Nanostring
Nanostring NCounter
Real-time qPCR
RNAseq
Sequencing - DNA Sequencing
Sequencing - Next Generation Sequencing (NGS)
Single-cell Sequencing
Spatial Transcriptomics
Whole Exome Sequencing
Whole Genome Sequencing
1.) Veluri R, Pollin G, Wagenknecht JB, Urrutia R, Zimmermann MT (2025 Feb 5). An Integrative Multitiered Computational Analysis for Better Understanding the Structure and Function of 85 Miniproteins bioRxiv, (), 2025.01.31.635936. . PMCID: 11838408.
2.) Cantarero L, Roldán M, Rodríguez-Sanz M, Mathison AJ, Díaz-Osorio Y, Pijuan J, Frías M, Urrutia R, Hoenicka J, Palau F (2024 Dec 31). Abnormal redox balance at membrane contact sites causes axonopathy in GDAP1-related Charcot-Marie-Tooth disease Research Square, (), rs.3.rs-5682984. . PMCID: 11722552.
3.) Ergun P, Samuels TL, Mathison AJ, Plehhova K, Coyle C, Horvath L, Johnston N (2024 Oct 5). Global Transcriptomic Analysis of Topical Sodium Alginate Protection against Peptic Damage in an In Vitro Model of Treatment-Resistant Gastroesophageal Reflux Disease International Journal of Molecular Sciences, 25(19), 10714. . PMCID: 11605242.
4.) Slick RA, Sutton J, Haberman M, O'Brien BS, Tinklenberg JA, Mardikar A, Prom MJ, Beatka M, Gartz M, Vanden Avond MA, Siebers E, Mack DL, Gonzalez JP, Ebert AD, Nagaraju K, Lawlor MW (2024 Sep 5). High mobility group box 1 (HMGB1) is a potential disease biomarker in cell and mouse models of Duchenne muscular dystrophy Biology Open, 13(9), bio060542. . PMCID: 11391821.
5.) Pollin G, Mathison AJ, de Assuncao TM, Thomas A, Zeighami A, Salmonson A, Liu H, Urrutia G, Vankayala P, Pandol SJ, Hong JC, Zimmermann MT, Iovanna J, Jin VX, Urrutia R, Lomberk G (2024 Jun 14). Ehmt2 inactivation in pancreatic epithelial cells shapes the transcriptional landscape and inflammation response of the whole pancreas Frontiers in Genetics, 15(), 1412767. . PMCID: 11211573.
6.) Kim J, Zimmermann MT, Mathison AJ, Lomberk G, Urrutia R, Hong JC (2024 May 13). Transcriptional Profiling Underscores the Role of Preprocurement Allograft Metabolism and Innate Immune Status on Outcomes in Human Liver Transplantation Annals of Surgery Open, 5(2), e444. . PMCID: 11191965.
7.) Pollin G, Mathison AJ, de Assuncao TM, Thomas A, Zeighami L, Salmonson A, Liu H, Urrutia G, Vankayala P, Pandol SJ, Zimmermann MT, Iovanna J, Jin VX, Urrutia R, Lomberk G (2024 Mar 16). EHMT2 Inactivation in Pancreatic Epithelial Cells Shapes the Transcriptional Landscape and Inflammation Response of the Whole Pancreas. bioRxiv : the preprint server for biology, (), . . PMID: 38529489.
8.) Pollin G, Mathison AJ, de Assuncao TM, Thomas A, Zeighami A, Salmonson A, Liu H, Urrutia G, Vankayala P, Pandol SJ, Hong JC, Zimmermann MT, Iovanna J, Jin VX, Urrutia R, Lomberk G (2024). Ehmt2 inactivation in pancreatic epithelial cells shapes the transcriptional landscape and inflammation response of the whole pancreas. Frontiers in genetics, 15(), 1412767. . PMID: 38948355.
9.) Ratnasinghe BD, Haque N, Wagenknecht JB, Jensen DR, Valdivia Esparza GK, Leverence EN, Milech De Assuncao T, Mathison AJ, Lomberk G, Smith BC, Volkman BF, Urrutia R, Zimmermann MT (2023 Oct 5). Beyond structural bioinformatics for genomics with dynamics characterization of an expanded KRAS mutational landscape Computational and Structural Biotechnology Journal, 21(), 4790-4803. . PMCID: 10570560.
10.) Ratnasinghe BD, Haque N, Wagenknecht JB, Jensen DR, Esparza GV, Leverence EN, De Assuncao TM, Mathison AJ, Lomberk G, Smith BC, Volkman BF, Urrutia R, Zimmermann MT (2023 Apr 28). Beyond Structural Bioinformatics for Genomics with Dynamics Characterization of an Expanded KRAS Mutational Landscape bioRxiv, (), 2023.04.28.536249. . PMCID: 10189839.
11.) Kleman A, Singavi AK, Pommert L, Mathison AJ, Hari P, Dhakal B, Mohan M, Janz S, Knight JM, Shah MV, Schinke C, Burns RT, Steinhardt GF, Rao S, Carlson KB (2023 Feb 1). A timeline of genetic variant enrichment: from multiple myeloma diagnosis to myeloma-associated myeloid malignancy. Blood advances, (), . pii: bloodadvances.2022008953. doi: 10.1182/bloodadvances.2022008953. ID: 36724511.
12.) Han L, Wu Y, Fang K, Sweeney S, Roesner UK, Parrish M, Patel K, Walter T, Piermattei J, Trimboli A, Lefler J, Timmers CD, Yu XZ, Jin VX, Zimmermann MT, Mathison AJ, Urrutia R, Ostrowski MC, Leone G (2023 Jan 3). The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis. Nature communications, 14(1), 1. . ID: 36596776.
13.) Stabenau KA, Samuels TL, Lam TK, Mathison AJ, Wells C, Altman KW, Battle MA, Johnston N (2023 Jan). Pepsinogen/Proton Pump Co-Expression in Barrett The Laryngoscope, 133(1), 59-69. doi: 10.1002/lary.30109. ID: 35315085.
14.) Hong-Le T, Crouse WL, Keele GR, Holl K, Seshie O, Tschannen M, Craddock A, Das SK, Szalanczy AM, McDonald B, Grzybowski M, Klotz J, Sharma NK, Geurts AM, Key CC, Hawkins G, Valdar W, Mott R, Solberg Woods LC (2023 Jan 1). Genetic Mapping of Multiple Traits Identifies Novel Genes for Adiposity, Lipids, and Insulin Secretory Capacity in Outbred Rats. Diabetes, 72(1), 135-148. . ID: 36219827.
15.) Fang S, Wu J, Reho JJ, Lu KT, Brozoski DT, Kumar G, Werthman AM, Silva SD Jr, Muskus Veitia PC, Wackman KK, Mathison AJ, Teng BQ, Lin CW, Quelle FW, Sigmund CD (2022 May 9). RhoBTB1 reverses established arterial stiffness in angiotensin II-induced hypertension by promoting actin depolymerization. JCI insight, 7(9), . . ID: 35358093.
16.) Xie Y, Nishijima Y, Zinkevich NS, Korishettar A, Fang J, Mathison AJ, Zimmermann MT, Wilcox DA, Gutterman DD, Shen Y, Zhang DX (2022 Apr 25). NADPH oxidase 4 contributes to TRPV4-mediated endothelium-dependent vasodilation in human arterioles by regulating protein phosphorylation of TRPV4 channels. Basic research in cardiology, 117(1), 24. . ID: 35469044.
17.) Allison RL, Adelman JW, Abrudan J, Urrutia RA, Zimmermann MT, Mathison AJ, Ebert AD (2022 Jan 27). Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons. Genes, 13(2), . . ID: 35205286.
18.) Stodola TJ, Chi YI, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R (2022 Jan). Computational modeling reveals key molecular properties and dynamic behavior of disruptor of telomeric silencing 1-like (DOT1L) and partnering complexes involved in leukemogenesis. Proteins, 90(1), 282-298. . ID: 34414607.
19.) Tripathi S, Dsouza NR, Mathison AJ, Leverence E, Urrutia R, Zimmermann MT (2022). Enhanced interpretation of 935 hotspot and non-hotspot RAS variants using evidence-based structural bioinformatics. Computational and structural biotechnology journal, 20(), 117-127. . ID: 34976316.
20.) Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R (2022). Structural bioinformatics enhances the interpretation of somatic mutations in KDM6A found in human cancers. Computational and structural biotechnology journal, 20(), 2200-2211. . ID: 35615018.
21.) Stancill JS, Hansen PA, Mathison AJ, Schmidt EE, Corbett JA (2022). Deletion of Thioredoxin Reductase Disrupts Redox Homeostasis and Impairs β-Cell Function. Function (Oxford, England), 3(4), zqac034. . ID: 35873655.
22.) Stabenau KA, Zimmermann MT, Mathison A, Zeighami A, Samuels TL, Chun RH, Papsin BC, McCormick ME, Johnston N, Kerschner JE (2021 Nov). RNA Sequencing and Pathways Analyses of Middle Ear Epithelia From Patients With Otitis Media. The Laryngoscope, 131(11), 2590-2597. doi: 10.1002/lary.29551. ID: 33844317.
23.) Mathison AJ, Kerketta R, de Assuncao TM, Leverence E, Zeighami A, Urrutia G, Stodola TJ, di Magliano MP, Iovanna JL, Zimmermann MT, Lomberk G, Urrutia R (2021 Oct 14). Kras(G12D) induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells. Genome biology, 22(1), 289. . ID: 34649604.
24.) Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Basel DG, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R (2021 Jun 1). Correction to: Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction. Orphanet journal of rare diseases, 16(1), 247. . ID: 34074320.
25.) Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Basel DG, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R (2021 Feb 5). Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction. Orphanet journal of rare diseases, 16(1), 66. . ID: 33546721.
26.) Zimmermann MT, Mathison AJ, Stodola T, Evans DB, Abrudan JL, Demos W, Tschannen M, Aldakkak M, Geurts J, Lomberk G, Tsai S, Urrutia R (2021). Interpreting Sequence Variation in PDAC-Predisposing Genes Using a Multi-Tier Annotation Approach Performed at the Gene, Patient, and Cohort Level. Frontiers in oncology, 11(), 606820. . ID: 33747920.
27.) Urrutia G, de Assuncao TM, Mathison AJ, Salmonson A, Kerketta R, Zeighami A, Stodola TJ, Adsay V, Pehlivanoglu B, Dwinell MB, Zimmermann MT, Iovanna JL, Urrutia R, Lomberk G (2021). Inactivation of the Euchromatic Histone-Lysine N-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by Altering Growth and Immune Gene Expression Networks. Frontiers in cell and developmental biology, 9(), 681153. . ID: 34249932.
28.) Danes JM, de Abreu ALP, Kerketta R, Huang Y, Palma FR, Gantner BN, Mathison AJ, Urrutia RA, Bonini MG (2020 Dec). Inorganic arsenic promotes luminal to basal transition and metastasis of breast cancer. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(12), 16034-16048. . ID: 33047385.
29.) Mathison A, Milech De Assuncao T, Dsouza NR, Williams M, Zimmermann MT, Urrutia R, Lomberk G (2020). Discovery, expression, cellular localization, and molecular properties of a novel, alternative spliced HP1γ isoform, lacking the chromoshadow domain. PloS one, 15(2), e0217452. . ID: 32027651.
30.) Cumming SA, Hamilton MJ, Robb Y, Gregory H, McWilliam C, Cooper A, Adam B, McGhie J, Hamilton G, Herzyk P, Tschannen MR, Worthey E, Petty R, Ballantyne B, Warner J, Farrugia ME, Longman C, Monckton DG (2018 Nov). De novo repeat interruptions are associated with reduced somatic instability and mild or absent clinical features in myotonic dystrophy type 1. European journal of human genetics : EJHG, 26(11), 1635-1647. . ID: 29967337.
31.) Pomerantz DJ, Ferdinandusse S, Cogan J, Cooper DN, Reimschisel T, Robertson A, Bican A, McGregor T, Gauthier J, Millington DS, Andrae JLW, Tschannen MR, Helbling DC, Demos WM, Denis S, Wanders RJA, Newman JN, Hamid R, Phillips JA 3rd (2018 Mar). Clinical heterogeneity of mitochondrial NAD kinase deficiency caused by a NADK2 start loss variant. American journal of medical genetics. Part A, 176(3), 692-698. . ID: 29388319.
32.) Keele GR, Prokop JW, He H, Holl K, Littrell J, Deal A, Francic S, Cui L, Gatti DM, Broman KW, Tschannen M, Tsaih SW, Zagloul M, Kim Y, Baur B, Fox J, Robinson M, Levy S, Flister MJ, Mott R, Valdar W, Solberg Woods LC (2018 Jan). Genetic Fine-Mapping and Identification of Candidate Genes and Variants for Adiposity Traits in Outbred Rats. Obesity (Silver Spring, Md.), 26(1), 213-222. . ID: 29193816.
33.) Scalais E, Osterheld E, Weitzel C, De Meirleir L, Mataigne F, Martens G, Shaikh TH, Coughlin CR 2nd, Yu HC, Swanson M, Friederich MW, Scharer G, Helbling D, Wendt-Andrae J, Van Hove JLK (2017 Jun). X-Linked Cobalamin Disorder (HCFC1) Mimicking Nonketotic Hyperglycinemia With Increased Both Cerebrospinal Fluid Glycine and Methylmalonic Acid. Pediatric neurology, 71(), 65-69. doi: 10.1016/j.pediatrneurol.2016.12.003. ID: 28363510.
34.) Xia S, Kohli M, Du M, Dittmar RL, Lee A, Nandy D, Yuan T, Guo Y, Wang Y, Tschannen MR, Worthey E, Jacob H, See W, Kilari D, Wang X, Hovey RL, Huang CC, Wang L (2015 Jun 30). Plasma genetic and genomic abnormalities predict treatment response and clinical outcome in advanced prostate cancer. Oncotarget, 6(18), 16411-21. . ID: 25915538.
35.) Du M, Yuan T, Schilter KF, Dittmar RL, Mackinnon A, Huang X, Tschannen M, Worthey E, Jacob H, Xia S, Gao J, Tillmans L, Lu Y, Liu P, Thibodeau SN, Wang L (2015 Jan 1). Prostate cancer risk locus at 8q24 as a regulatory hub by physical interactions with multiple genomic loci across the genome. Human molecular genetics, 24(1), 154-66. . ID: 25149474.
36.) Tsaih SW, Holl K, Jia S, Kaldunski M, Tschannen M, He H, Andrae JW, Li SH, Stoddard A, Wiederhold A, Parrington J, Ruas da Silva M, Galione A, Meigs J, Hoffmann RG, Simpson P, Jacob H, Hessner M, Solberg Woods LC (2014 Sep). Identification of a novel gene for diabetic traits in rats, mice, and humans. Genetics, 198(1), 17-29. . ID: 25236446.
37.) Jacob HJ, Abrams K, Bick DP, Brodie K, Dimmock DP, Farrell M, Geurts J, Harris J, Helbling D, Joers BJ, Kliegman R, Kowalski G, Lazar J, Margolis DA, North P, Northup J, Roquemore-Goins A, Scharer G, Shimoyama M, Strong K, Taylor B, Tsaih SW, Tschannen MR, Veith RL, Wendt-Andrae J, Wilk B, Worthey EA (2013 Jul 17). Genomics in clinical practice: lessons from the front lines. Science translational medicine, 5(194), 194cm5. doi: 10.1126/scitranslmed.3006468. ID: 23863829.
38.) Flister MJ, Prisco SZ, Sarkis AB, O (2012 Oct). Identification of hypertension susceptibility loci on rat chromosome 12. Hypertension (Dallas, Tex. : 1979), 60(4), 942-8. . ID: 22868394.
39.) Liu P, Morrison C, Wang L, Xiong D, Vedell P, Cui P, Hua X, Ding F, Lu Y, James M, Ebben JD, Xu H, Adjei AA, Head K, Andrae JW, Tschannen MR, Jacob H, Pan J, Zhang Q, Van den Bergh F, Xiao H, Lo KC, Patel J, Richmond T, Watt MA, Albert T, Selzer R, Anderson M, Wang J, Wang Y, Starnes S, Yang P, You M (2012 Jul). Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing. Carcinogenesis, 33(7), 1270-6. . ID: 22510280.
40.) Worthey EA, Mayer AN, Syverson GD, Helbling D, Bonacci BB, Decker B, Serpe JM, Dasu T, Tschannen MR, Veith RL, Basehore MJ, Broeckel U, Tomita-Mitchell A, Arca MJ, Casper JT, Margolis DA, Bick DP, Hessner MJ, Routes JM, Verbsky JW, Jacob HJ, Dimmock DP (2011 Mar). Making a definitive diagnosis: successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease. Genetics in medicine : official journal of the American College of Medical Genetics, 13(3), 255-62. doi: 10.1097/GIM.0b013e3182088158. ID: 21173700.
41.) Solberg Woods LC, Holl K, Tschannen M, Valdar W (2010 Mar 3). Fine-mapping a locus for glucose tolerance using heterogeneous stock rats. Physiological genomics, 41(1), 102-8. . ID: 20068026.
42.) Adamovic T, McAllister D, Guryev V, Wang X, Andrae JW, Cuppen E, Jacob HJ, Sugg SL (2009 Jun 15). Microalterations of inherently unstable genomic regions in rat mammary carcinomas as revealed by long oligonucleotide array-based comparative genomic hybridization. Cancer research, 69(12), 5159-67. doi: 10.1158/0008-5472.CAN-08-4038. ID: 19509235.
43.) Moreno C, Kennedy K, Andrae JW, Jacob HJ (2005). Genome-wide scanning with SSLPs in the rat. Methods in molecular medicine, 108(), 131-8. . ID: 16028680.
44.) Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ (2004 Apr). High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Genome research, 14(4), 750-7. . ID: 15060019.
Saving lives and improving the wellness of individual citizens and the community by advancing genomic sciences and precision medicine.
Pioneering the fields of Omics, Data Science, and Systems Biology to discover and innovate across our four programs.
The Mellowes Center has its roots in the launch of the Human Genome Project and the 1999 founding of the MCW Human and Molecular Genetics Center. The Mellowes Center uses state-of-the-art whole genome sequencing technologies not only to investigate how gene variants impact gene expression but also to define genetic variants associated with both rare and common disease, embryonic development, and the effects of environmental factors and drugs upon gene expression and disease.
