California NanoSystems Institute

Contact Info:

Matthew Mecklenburg

570 Westwood Plaza

Building 114

Los Angeles, CA 90095

https://eicn.cnsi.ucla.edu/

Grants and Identifiers:

RRID: RRID:SCR_022900

Instrumentation:

Other Equipment

TFS Titan Krios High-Resolution; Cryo EM & CryoET Titan S/TEM (FEI) TF20 High-Resolution EM, CryoEM & CryoET (FEI) T20 iCorr (FEI) High-Resolution CryoEM & CryoET Correlative Microscopy T12 Quick Room Temperature TEM Zeiss Supra 40VP SEM EM PACT-RTS High Pressure Freezer (Leica) EM AFS S2 Automatic Freeze Substitution (Leica) BTT-IV Evaporator (Denton Vacuum) Tousimis Autosamdri- 810 Critical Point Dryer Vitrobot Mark IV Cryosample Plunger South Bay Technology Ion Beam Sputtering/ Etching System Gatan Plasma System SOLARUS Manual Plunger AKTA pure 25 M1 Fast Performance LC Akta Columns Pelco SC-7 UCT Ultramicrotome (Leica) UC6 Cryo Ultramicrotome (Leica) LKB 7800 KnifeMaker

Services Provided:

Cryo-Electron Microscopy

Electron Microscopy

Microscopy

Microtomy/Electron

Scanning Electron Microscopy

Training

Relevant Publications:

1.) Cheng X, Li Z, Zhu J, Wang J, Huang R, Yu LW, Lin S, Forman S, Gromilina E, Puri S, Patel P, Bahramian M, Tan J, Hojaiji H, Jelinek D, Voisin L, Yu KB, Zhang A, Ho C, Lei L, Coller HA, Hsiao EY, Reyes BL, Matsumoto JH, Lu DC, Liu C, Milla C, Davis RW, Emaminejad S (2025 Feb 27). Tandem metabolic reaction–based sensors unlock in vivo metabolomics Proceedings of the National Academy of Sciences of the United States of America, 122(9), e2425526122. . PMCID: 11892595.

2.) Shannon DP, Cerdan K, Kim M, Mecklenburg M, Su J, Chen Y, Helgeson ME, Valentine MT, Hawker CJ (2024 Dec 6). Bioinspired Metal–Ligand Networks with Enhanced Stability and Performance: Facile Preparation of Hydroxypyridinone (HOPO)-Functionalized Materials Macromolecules, 57(24), 11339-11349. . PMCID: 11684171.

Description:

Seeing molecules, materials, and molecular machineries at atomic resolution and in three-dimension is critical to nanoscience. In order to facilitate this, the Electron Imaging Center for Nanomachines (EICN) was established at the California NanoSystems Institute (CNSI) through a major instrumentation grant from NIH and support from UCLA. EICN provides advanced electron imaging tools for a broad range of research, covering a scale range from tens of micrometers to angstroms, and delivering valuable structural information for cell biology, microbiology, biomolecular, molecular, and materials sciences. The state-of-the-art EICN facility offers all major electron microscopy (EM) modalities.