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Penn State COM Biomolecular NMR

Penn State College of Medicine

Contact Info:

Fang Tian

Penn State College of Medicine

Hershey 17033

https://research.med.psu.edu/core-facilities/biomolecular-nmr/

Grants and Identifiers:

RRID: RRID:SCR_023244

Instrumentation:

(Equipment No Longer Active At this Facility)

Bruker 9.4T Biospec Biospec Magnetic Resonance Imaging

The BioSpec® series is an MRI system that performs preclinical and molecular MR imaging. MRI CryoProbe™ technology combined with ultra high field USR magnets deliver high spatial resolution in-vivo, thus enabling customers to come closer to the molecular and cellular level research they desire. Thanks to its innovative modular concept, virtually any small animal MR imaging application in life science, biomedical and preclinical research can be conducted. [Product Link]

RRID:SCR_018054

cite this instrument

Bruker 500 MHz NMR

Bruker 600 MHz NMR

Services Provided:

Consultation

Data Analysis

Data Analysis And Interpretation

Data Processing

Data Processing And Interpretation

Metabolomics

NMR Medicinal Chemistry Support

NMR Quality Control For Biologic Drugs

Nuclear Magnetic Resonance (NMR)

Structural Biology

Structure Determination

Relevant Publications:

1.) Ye Y, Liang X, Wang G, Bewley MC, Hamamoto K, Liu X, Flanagan JM, Wang HG, Takahashi Y, Tian F (2024 Mar 15). Identification of membrane curvature sensing motifs essential for VPS37A phagophore recruitment and autophagosome closure Communications Biology, 7(), 334. . PMCID: 10942982.


2.) Ye Y, Bewley MC, Wang HG, Tian F, Flanagan JM (2024 Mar). What's in an E3: role of highly curved membranes in facilitating LC3-phosphatidylethanolamine conjugation during autophagy. Autophagy, 20(3), 709-711. . PMID: 38032155.


3.) Ye Y, Tyndall ER, Bui V, Tang Z, Shen Y, Jiang X, Flanagan JM, Wang HG, Tian F (2021 Jan 14). An N-terminal conserved region in human Atg3 couples membrane curvature sensitivity to conjugase activity during autophagy. Nature communications, 12(1), 374. . ID: 33446636.


4.) Fu R, Gill RL Jr, Kim EY, Briley NE, Tyndall ER, Xu J, Li C, Ramamurthi KS, Flanagan JM, Tian F (2015 Nov 11). Spherical nanoparticle supported lipid bilayers for the structural study of membrane geometry-sensitive molecules. Journal of the American Chemical Society, 137(44), 14031-14034. . ID: 26488086.


5.) Tash BR, Bewley MC, Russo M, Keil JM, Griffin KA, Sundstrom JM, Antonetti DA, Tian F, Flanagan JM (2012 Jul 3). The occludin and ZO-1 complex, defined by small angle X-ray scattering and NMR, has implications for modulating tight junction permeability. Proceedings of the National Academy of Sciences of the United States of America, 109(27), 10855-60. . ID: 22711802.


6.) Wang X, Tash B, Flanagan JM, Tian F (2011 Feb). RDC derived protein backbone resonance assignment using fragment assembly. Journal of biomolecular NMR, 49(2), 85-98. . ID: 21191805.


Description:

Our mission is to facilitate investigators to use multiple modern NMR applications, including structure elucidation of small molecules, triple resonance experiments of biomolecules, fragment-based drug discovery, metabolomic and tissue analyses.