University of Pennsylvania

Contact Info:

Heather W Collins

3400 Civic Center Blvd, bldg 421

12-183 Smilow

Philadelphia, PA 19104

https://www.med.upenn.edu/idom/drc/cores/ria.html

Grants and Identifiers:

RRID: RRID:SCR_022405

P30-DK19525

Instrumentation:

Services Provided:

Relevant Publications:

1.) Poddar S, Chauvin SD, Archer CH, Qian W, Castillo-Badillo JA, Yin X, Disbennett WM, Miner CA, Holley JA, Naismith TV, Stinson WA, Wei X, Ning Y, Fu J, Ochoa TA, Surve N, Zaver SA, Wodzanowski KA, Balka KR, Venkatraman R, Liu C, Rome K, Bailis W, Shiba Y, Cherry S, Shin S, Semenkovich CF, De Nardo D, Yoh S, Roberson EDO, Chanda SK, Kast DJ, Miner JJ (2025 Mar 20). ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation. Cell, 188(6), 1605-1622.e26. . PMCID: 11928284.

Description:

Core offers immunoassay, metabolite, and HPLC services to basic, translational, and clinical investigators performing diabetes and related metabolic disease research.RIA /Biomarkers Core is located on the 12th floor of Smilow Center for Translational Research. Approximately 100 different diabetes, obesity and metabolism-related biomarkers from multiple species including human can be assayed using radioimmunoassay (RIA), enzyme-linked immunosorbent assay (ELISA, both absorbance and fluorometric), multiplex ELISA on the Luminex platform, and enzymatic and HPLC methods for an expanding variety of diabetes and metabolism related metabolites, hormones, catecholamines and cytokines derived from blood, urine, and tissue samples.