University of Pennsylvania
Sara Cherry
https://www.med.upenn.edu/cores/assets/user-content/documents/HTSC_overview_27May2015.pdf
RRID: RRID:SCR_022379
1.) Bhakt P, Pokharel SM, Li Y, Srivastava T, Miller J, Dittmar M, Zhu Y, Nguyen D, Walter Z, Ayyanathan K, Tudor M, Yu C, Chatterjee AK, Ramage H, Schultz D, Cherry S (2026 Feb). NS5-targeting nucleoside analogs inhibit dengue virus and other flaviviruses. PLoS pathogens, 22(2), e1013970. . PMCID: 12928577.
2.) Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R (2025 May). Snapshots of acyl carrier protein shuttling in human fatty acid synthase. Nature, 641(8062), 520-528. . PMCID: 12058525.
3.) Riscal R, Gardner SM, Coffey NJ, Carens M, Mesaros C, Xu JP, Xue Y, Davis L, Demczyszyn S, Vogt A, Olia A, Finan JM, Godfrey J, Schultz DC, Blair IA, Keith B, Marmorstein R, Skuli N, Simon MC (2024 May 15). Bile acid metabolism mediates cholesterol homeostasis and promotes tumorigenesis in clear cell renal cell carcinoma Cancer research, 84(10), 1570-1582. . PMCID: 11096083.
4.) Ding J, Smith AB 3rd (2023 Aug 23). Total Synthesis of the Reported Structure of Neaumycin B. Journal of the American Chemical Society, 145(33), 18240-18246. . PMCID: 10848393.
Core provides distribution of lentivirus based shRNA and cDNA plasmid DNA clones; technical expertise in developing biological assays (i.e. biochemical-, cell-, and high-content) in miniaturized, multiwell microtiter plates that are laboratory automation compatible; high-throughput chemical and functional genomic screening, including data analysis and interpretation. Our goal is to use cutting biological models to discover genes and small molecules that enable scientists to further study functions of poorly understood proteins, signaling pathways, and cells in complex biological process relevant to human physiology and disease.
