University of Pennsylvania

Contact Info:

Joseph Baur

https://www.med.upenn.edu/idom/drc/cores/rodent.html

Grants and Identifiers:

RRID: RRID:SCR_022427

Instrumentation:

Services Provided:

Relevant Publications:

1.) Song F, Marmo T, Song C, Liao X, Long F (2024 Sep 23). Wnt7b overexpression in osteoblasts stimulates bone formation and reduces obesity in mice on a high-fat diet JBMR Plus, 8(11), ziae122. . PMCID: 11491285.

2.) Nunn E, Jaiswal N, Gavin M, Uehara K, Stefkovich M, Drareni K, Calhoun R, Lee M, Holman CD, Baur JA, Seale P, Titchenell PM (2024 Jan 11). Antibody blockade of activin type II receptors preserves skeletal muscle mass and enhances fat loss during GLP-1 receptor agonism Molecular Metabolism, 80(), 101880. . PMCID: 10832506.

Description:

Core (RMPC, formerly MPPMC) is metabolic core. Offers technology and phenotyping services to allow investigators to study metabolism in pre-clinical rodent models. Services include measurements of body composition (fat and lean mass) using NMR and DEXA, energy balance (food intake, locomotor activity, energy expenditure) using indirect calorimetry in either Columbus Instruments CLAMS system or Sable Systems Promethion System (with optional gas analyzer), and other in vivo metabolic phenotyping services (glucose clamps, insulin and glucose tolerance tests, telemetric monitoring of blood glucose or blood pressure, bomb calorimetry).