University of Pennsylvania
Chris Petucci
https://www.med.upenn.edu/cvi/metabolomics-core.html
RRID: RRID:SCR_022381
1.) Glass BH, Barott KL (2025 Jun 27). Hypoxia disrupts metabolism in coral and sea anemone larvae The Journal of Experimental Biology, 228(12), jeb250372. . PMCID: 12268173.
2.) Naeem F, Leone TC, Petucci C, Shoffler C, Kodihalli RC, Hidalgo T, Tow‐Keogh C, Mancuso J, Tzameli I, Bennett D, Groarke JD, Roth Flach RJ, Rader DJ, Kelly DP (2025 Apr 15). Plasma metabolomics identifies signatures that distinguish heart failure with reduced and preserved ejection fraction ESC Heart Failure, 12(4), 2803-2813. . PMCID: 12287786.
3.) Sule R, Hu P, Shoffler C, Petucci C, Wilkins BJ, Rychik J, Pei L (2025 Mar 7). Comprehensive Multiomic Analysis Reveals Metabolic Reprogramming Underlying Human Fontan‐Associated Liver Disease Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 14(6), e039201. . PMCID: 12132697.
4.) Markosyan N, Kim IK, Arora C, Quinones-Ware L, Joshi N, Cheng N, Schechter EY, Tobias JW, Hochberg JE, Corse E, Liu K, Rodriguez DiBlasi V, Chan LC, Smyth EM, FitzGerald GA, Stanger BZ, Vonderheide RH (2024 Nov 8). Pivotal roles for cancer cell–intrinsic mPGES-1 and autocrine EP4 signaling in suppressing antitumor immunity JCI Insight, 9(21), e178644. . PMCID: 11601572.
5.) Weissenrieder JS, Peura J, Paudel U, Bhalerao N, Weinmann N, Johnson C, Wengyn M, Drager R, Furth EE, Simin K, Ruscetti M, Stanger BZ, Rustgi AK, Pitarresi JR, Foskett JK (2024 Aug 9). Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity bioRxiv, (), 2024.08.08.607195. . PMCID: 11326289.
6.) Naeem F, Leone TC, Petucci C, Shoffler C, Kodihalli RC, Hidalgo T, Tow-Keogh C, Mancuso J, Tzameli I, Bennett D, Groarke JD, Flach RJ, Rader DJ, Kelly DP (2024 Jul 25). Targeted Quantitative Plasma Metabolomics Identifies Metabolite Signatures that Distinguish Heart Failure with Reduced and Preserved Ejection Fraction medRxiv, (), 2024.07.24.24310961. . PMCID: 11302718.
7.) Berger JH, Matsuura TR, Bowman CE, Taing R, Patel J, Lai L, Leone TC, Reagan JD, Haldar SM, Arany Z, Kelly DP (2024 Jul 23). SGLT2 Inhibitors Act Independently of SGLT2 to Confer Benefit for HFrEF in Mice Circulation research, 135(5), 632-634. . PMCID: 11326968.
8.) Flores-Mendez M, Ohl L, Roule T, Zhou Y, Tintos-Hernández JA, Walsh K, Ortiz-González XR, Akizu N (2024 Jan 22). IMPDH2 filaments protect from neurodegeneration in AMPD2 deficiency bioRxiv, (), 2024.01.20.576443. . PMCID: 10849482.
Core is overseen by Cardiovascular Institute and is partnership with the Abramson Cancer Center and the Institute for Diabetes, Obesity and Metabolism at Penn. Provides expertise in targeted and untargeted metabolomics of biological samples using liquid chromatography/mass spectrometry. Performs assays and assists in interpretation of results.
