University of Pennsylvania
Enrico Radaelli
3800 Spruce Street
Philadelphia, PA 19104
https://www.vet.upenn.edu/research/core-resources-facilities/comparative-pathology-core
RRID: RRID:SCR_022438
Other Citation IdentifiersP30CA016520
S10OD023465-01A1
Leica Bond RX IHC/ISH autostainer
Aperio Leica Versa 200 whole slide scanner
Consultation
Cryostat Histology
Fluorescence Microscope With Optical Sectioning Capability
Processing & Embedding- Histology
Scanning 20X Brightfield
Scanning 20X Fluorescent
Scanning 40X Brightfield
Veterinary Pathology
1.) Bardales KL, Jiang L, Radaelli E, Assenmacher CA, Lenz JA, Atherton MJ (2025 Mar 14). Intertumoral heterogeneity of the immune microenvironment in high grade canine mast cell tumors Veterinary Oncology (London, England), 2(1), 7. . PMCID: 11906493.
2.) Stewart DC, Brisson BK, Dekky B, Berger AC, Yen W, Mauldin EA, Loebel C, Gillette D, Assenmacher CA, Quincey C, Stefanovski D, Cristofanilli M, Cukierman E, Burdick JA, Borges VF, Volk SW (2024 Oct 2). Prognostic and therapeutic implications of tumor-restrictive type III collagen in the breast cancer microenvironment NPJ Breast Cancer, 10(), 86. . PMCID: 11447064.
3.) Xiao Z, Todd L, Huang L, Noguera-Ortega E, Lu Z, Huang L, Kopp M, Li Y, Pattada N, Zhong W, Guo W, Scholler J, Liousia M, Assenmacher CA, June CH, Albelda SM, Puré E (2023 Aug 22). Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors Nature Communications, 14(), 5110. . PMCID: 10444764.
4.) Kalbasi A, Siurala M, Su LL, Tariveranmoshabad M, Picton LK, Ravikumar P, Li P, Lin JX, Escuin-Ordinas H, Da T, Kremer SV, Sun AL, Castelli S, Agarwal S, Scholler J, Song D, Rommel PC, Radaelli E, Young RM, Leonard WJ, Ribas A, June CH, Garcia KC (2022 Jul). Potentiating adoptive cell therapy using synthetic IL-9 receptors. Nature, 607(7918), 360-365. doi: 10.1038/s41586-022-04801-2. ID: 35676488.
5.) Verginadis II, Avgousti H, Monslow J, Skoufos G, Chinga F, Kim K, Leli NM, Karagounis IV, Bell BI, Velalopoulou A, Salinas CS, Wu VS, Li Y, Ye J, Scott DA, Osterman AL, Sengupta A, Weljie A, Huang M, Zhang D, Fan Y, Radaelli E, Tobias JW, Rambow F, Karras P, Marine JC, Xu X, Hatzigeorgiou AG, Ryeom S, Diehl JA, Fuchs SY, Puré E, Koumenis C (2022 Jun). A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression. Nature cell biology, 24(6), 940-953. doi: 10.1038/s41556-022-00918-8. ID: 35654839.
6.) Snyder JM, Radaelli E, Goeken A, Businga T, Boyden AW, Karandikar NJ, Gibson-Corley KN (2022 May). Perfusion with 10% neutral-buffered formalin is equivalent to 4% paraformaldehyde for histopathology and immunohistochemistry in a mouse model of experimental autoimmune encephalomyelitis. Veterinary pathology, 59(3), 498-505. doi: 10.1177/03009858221075588. ID: 35130806.
7.) Lawrence KM, Radaelli E, McGovern PE, Licht DJ, Davey MG, Flake AW, Gaynor JW, Vossough A (2022 Apr 19). Radiographic and histologic characterisation of white matter injury in a sheep model of CHD. Cardiology in the young, (), 1-5. . ID: 35438073.
8.) Lenz JA, Assenmacher CA, Costa V, Louka K, Rau S, Keuler NS, Zhang PJ, Maki RG, Durham AC, Radaelli E, Atherton MJ (2022 Apr). Increased tumor-infiltrating lymphocyte density is associated with favorable outcomes in a comparative study of canine histiocytic sarcoma. Cancer immunology, immunotherapy : CII, 71(4), 807-818. doi: 10.1007/s00262-021-03033-z. ID: 34415404.
9.) Keiser MS, Ranum PT, Yrigollen CM, Carrell EM, Smith GR, Muehlmatt AL, Chen YH, Stein JM, Wolf RL, Radaelli E, Lucas TJ 2nd, Gonzalez-Alegre P, Davidson BL (2021 Nov). Toxicity after AAV delivery of RNAi expression constructs into nonhuman primate brain. Nature medicine, 27(11), 1982-1989. doi: 10.1038/s41591-021-01522-3. ID: 34663988.
10.) Velalopoulou A, Karagounis IV, Cramer GM, Kim MM, Skoufos G, Goia D, Hagan S, Verginadis II, Shoniyozov K, Chiango J, Cerullo M, Varner K, Yao L, Qin L, Hatzigeorgiou AG, Minn AJ, Putt M, Lanza M, Assenmacher CA, Radaelli E, Huck J, Diffenderfer E, Dong L, Metz J, Koumenis C, Cengel KA, Maity A, Busch TM (2021 Sep 15). FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response. Cancer research, 81(18), 4808-4821. . ID: 34321243.
11.) Chen KW, Demarco B, Ramos S, Heilig R, Goris M, Grayczyk JP, Assenmacher CA, Radaelli E, Joannas LD, Henao-Mejia J, Tacchini-Cottier F, Brodsky IE, Broz P (2021 Jul 13). RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling. Proceedings of the National Academy of Sciences of the United States of America, 118(28), . . ID: 34260403.
12.) Santagostino SF, Assenmacher CA, Tarrant JC, Adedeji AO, Radaelli E (2021 Jul). Mechanisms of Regulated Cell Death: Current Perspectives. Veterinary pathology, 58(4), 596-623. doi: 10.1177/03009858211005537. ID: 34039100.
13.) Breda L, Ghiaccio V, Tanaka N, Jarocha D, Ikawa Y, Abdulmalik O, Dong A, Casu C, Raabe TD, Shan X, Danet-Desnoyers GA, Doto AM, Everett J, Bushman FD, Radaelli E, Assenmacher CA, Tarrant JC, Hoepp N, Kurita R, Nakamura Y, Guzikowski V, Smith-Whitley K, Kwiatkowski JL, Rivella S (2021 Apr 7). Lentiviral vector ALS20 yields high hemoglobin levels with low genomic integrations for treatment of beta-globinopathies. Molecular therapy : the journal of the American Society of Gene Therapy, 29(4), 1625-1638. . ID: 33515514.
14.) Assenmacher CA, Santagostino SF, Oyama MA, Marine JC, Bonvin E, Radaelli E (2021 Mar). Classification and Grading of Melanocytic Lesions in a Mouse Model of <i>NRAS</i>-driven Melanomagenesis. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 69(3), 203-218. doi: 10.1369/0022155420977970. ID: 33283624.
Provides support to investigators utilizing animal models to study disease. Comparative Pathology Core, Abramson Cancer Center shared resource, provides expert pathological characterization and validation of mouse and other animal models used in biomedical research by offering expertise of board certified veterinary pathologists and access to histology, immunohistochemistry, and digital pathology services.
