University of Pennsylvania

Contact Info:

Costas Koumenis

https://www.med.upenn.edu/carc/

Grants and Identifiers:

RRID: RRID:SCR_022377

Instrumentation:

Services Provided:

Relevant Publications:

1.) Kim K, Kim MM, Skoufos G, Diffenderfer ES, Motlagh SA, Kokkorakis M, Koliaki I, Morcos G, Shoniyozov K, Griffin J, Hatzigeorgiou AG, Metz JM, Lin A, Feigenberg SJ, Cengel KA, Ky B, Koumenis C, Verginadis II (2024 Feb 15). FLASH Proton Radiation Therapy Mitigates Inflammatory and Fibrotic Pathways and Preserves Cardiac Function in a Preclinical Mouse Model of Radiation-Induced Heart Disease International journal of radiation oncology, biology, physics, 119(4), 1234-1247. . PMCID: 11209795.

Description:

Core provides services to users for performing precision, image guided radiotherapy with both Photons and Protons (including FLASH proton radiotherapy) on cells, rodents and larger animals. Physicists will provide expert dosimetry and treatment planning capabilities. Instrumentation consists of two image guided SARRP 200 Small Animal Radiation Research Platforms (Xstrahl) capable of irradiating rodent tissues from 1 mm-120 mm in diameter; research proton beamline (IBA, Roberts Proton Center); one X-RAD 320ix cabinet x-ray irradiator (Precision X-Ray); and two Cs gamma-ray irradiators (Shepherd Mark I), suitable for whole body radiation of rodents.