Medical College of Wisconsin
Contact Info:
Kazuhiro Aoki
8701 Watertown Plank Rd
Milwaukee, WI 53226
Grants and Identifiers:
RRID: RRID:SCR_027908
Instrumentation:
Bruker timsTOF fleX with MALDI-2
Instrument for probing molecular content of sample with MALDI-2. The timsTOF fleX is fully functional high speed, high sensitivity ESI instrument for all X-Omics analyses, combined with high spatial resolution Matrix-Assisted Laser Desorption Ionization (MALDI) source and stage specifically designed for resolving molecular distributions and bringing spatial dimension to OMICS analyses.MALDI-2 uses laser post-ionization to enhance and enrich the MALDI experiment providing access to chemical classes typically opaque to MALDI with enhanced sensitivities. [Product Link]
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Dionex ICS-6000 Carbohydrate Removal Accessory Kit for ED Electrochemical Detection
Accessory for ion chromatography instruments that provides amino acid quantification by removing carbohydrates from amino acid samples in line. [Product Link]
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Thermo Exploris 240 LC/MS system
Exploris 240 system is hybrid quadrupole Orbitrap mass spectrometer with Waters H-Class Acquity, ZipChip, and DART front ends. Flexible platform for wide range of small molecule and intact protein analyses. [Product Link]
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Thermo Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer
Spectrometer performs analysis including low level PTM analysis, multiplexed relative quantitation using isobaric tags, intact protein characterization, and MSn analysis of small molecules. System incorporates the brightest ion source, segmented quadrupole mass filter with improved selectivity and ion transmission, Advanced Vacuum Technology, and ETD HD. [Product Link]
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Services Provided:
Crosslinking Mass Spectrometry
Label Free Quantitative Proteomics
Labeled Quantitative Proteomics -TMT And Other Labeling
Mass Spectrometry - Small Molecules
Relevant Publications:
Description:
The Mass Spectrometry Core delivers advanced LC-MS/MS and MALDI imaging mass spectrometry solutions across proteomics, lipidomics, metabolomics, glycomics, and spatial omics. We partner with investigators to provide end-to-end expertise in experimental design, optimized sample preparation, high-quality data acquisition, and in-depth analysis, supporting NIH-funded and translational research at both regional and national levels.
