Memorial Sloan Kettering Cancer Center
Contact Info:
George Sukenick
417 E 68th Street
New York, NY 10065
https://www.mskcc.org/research/ski/core-facilities/nuclear-magnetic-resonance-analytical
Grants and Identifiers:
RRID: RRID:SCR_027804
Instrumentation:
Bruker Avance NMR Spectrometer
Bruker’s Avance NMR spectrometers are utilized in various scientific fields to elucidate the structure, dynamics, and interactions of molecules. Avance spectrometers are composed of three main hardware components: console, which is the central control unit of the NMR spectrometer, and houses sophisticated electronics for the generation of the pulse sequences and for data acquisition and processing; superconducting magnet to generate homogenous and stable magnetic field to polarize the nuclear spins in the sample; probe for transmitting radiofrequency pulses and detecting the resulting signals from the sample. [Product Link]
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Bruker Invenio S FT-IR Spectrometer
Bruker Invenio S is an entry-level FT-IR spectrometer designed for routine productivity and basic research and development. Analytical instrument that identifies chemical compounds and molecular structures by measuring how samples absorb infrared light. Offers upgradable Invenio platform featuring the Transit channel and MultiTect technology. [Product Link]
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Bruker Sierra SPR-32 Pro Analyzer
High-throughput, 32-spot Surface Plasmon Resonance (SPR) system. The "Pro" designation commonly used by Bruker highlights its capabilities, including 8 flow cells with 4 spots each, designed for rapid, label-free molecular interaction analysis. Used for the Real-Time, Label-Free characterization of molecular interactions. [Product Link]
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Jasco P-2000 Digital Polarimeter
Customizable polarimeter used to measure the optical rotation of chiral compounds. It identifies, analyzes, and determines the purity and concentration of liquids (specifically optically active samples) in pharmaceutical, chemical, and food manufacturing industries, featuring customizable light sources for UV-Vis to NIR regions. [Product Link]
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Jasco V-750 UV-Vis Spectrophotometer
High resolution UV-Visible spectrophotometer with double-beam, single monochromator, variable spectral bandwidth and a photomultiplier tube (PMT) detector. Used for measuring absorbance, transmittance, and reflectance of liquid or solid samples across the UV-visible range 190-900nm. Used for quantitative analysis (concentration measurement) and spectral characterization. [Product Link]
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Waters Binary Gradient Modules Mixing Pumps
High pressure, precision solvent mixing pumps designed for HPLC and preparative scale purification. They mix two different solvents to create precise gradient compositions, allowing for, or improving, the separation and isolation of target compounds in chemical or biological samples. [Product Link]
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Waters Discovery TGA 5500 Thermal Analyzer
Thermogravimetric analyzer used to measure a material’s weight change (decomposition, oxidation, or dehydration) as it is heated, cooled, or held at a constant temperature. It is used in research and quality control to analyze polymers, pharmaceuticals, and composites for stability and composition. [Product Link]
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Waters SQ Detector 2 Mass Spectrometer
Compact benchtop single quadrupole mass spectrometer designed for routine, high-performance liquid chromatography (LC-MS) applications. Used for molecular weight confirmation, impurity identification, and quantitative analysis. Compatible with a broad range of chromatography platforms and ionization sources, including APCI and UniSpray, the SQ Detector 2 is the ultimate single quadrupole mass detector for chromatography. [Product Link]
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(Equipment No Longer Active At this Facility)
Waters SQD2 LC/MS system
System includes SQD2 as single quadrupole MS with Waters H-Class Acquity UPLC, operated as open access platform for trained users. SQ Detector2 is single quadrupole mass detector for chromatography compatible with range of chromatography platforms and ionization sources. [Product Link]
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Waters Xevo G3 TOF MS Mass Spectrometry System
High-resolution, benchtop Quadrupole Time-of-Flight mass spectrometer designed for characterizing small molecules and biotherapeutics. Used for analyzing complex samples, offering quantitative/qualitative data, and seamless integration with ACQUITY Premier LC systems. [Product Link]
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Services Provided:
HPLC-MS Analysis And Separation
Intact Mass Analysis Of Proteins/conjugates
Separation/Purification Services
SFC-MS Analysis And Separation
Relevant Publications:
Description:
The Nuclear Magnetic Resonance Analytical Core provides services and education for analytical instrumentation and related shared scientific resources. Instrumentation includes high field nuclear magnetic resonance, mass spectrometry, HPLC/UPLC, and optical spectroscopic instruments. This facility offers investigators the ability to monitor chemical reactions, analysis of mass and molecular structure, separation of materials, determine mechanisms, purity, stability, biological uptake, and other properties of chemical compounds, and intact mass analysis of proteins and their conjugates. We strive for fast turnaround of quality results.
