Memorial Sloan Kettering Cancer Center
Contact Info:
Elisa de Stanchina
417 E 68th Street
New York, NY 10065
https://www.mskcc.org/research/ski/core-facilities/antitumor-assessment
Grants and Identifiers:
RRID: RRID:SCR_027795
Instrumentation:
Services Provided:
In Vivo Efficacy Studies In Cell Line (CDX) Xenograft Models
In Vivo Efficacy Studies In Patient-derived (PDX) Xenograft Models
IND-enabling GLP Toxicology Studies In Mice
Relevant Publications:
Description:
The core supports early discovery and in vivo testing of antitumor detection and therapeutic agents. The ATA core works closely with investigators to establish preclinical models, including Patient-Derived Xenograft (PDX) and Organoid (PDO) models, and to design and execute pharmacokinetic (PK), tolerability, and in vivo efficacy studies in various mouse tumor models. Additionally, the Core performs GLP-compliant safety toxicology studies in support of IND applications for both diagnostic and therapeutic agents (small molecules, cell therapies, biologics) and can conduct PK studies in support of Phase I-II clinical trials.
