Jewish General Hospital

Contact Info:

Christian Young

https://www.ladydavis.ca/en/about/core-facilities/flow-cytometry/

Grants and Identifiers:

RRID: RRID:SCR_027644

Instrumentation:

Services Provided:

Relevant Publications:

1.) Santinon F, Papadopoulos T, Berg MH, McCallum P, Abraham MJ, Gonçalves C, Gupta V, Gagnon N, Wirasinghe N, Chou H, Esfahani K, Bartish M, Miller WH Jr, Del Rincon SV (2025 Nov 6). Lack of phospho-eIF4E worsens experimental colitis by inhibiting Treg suppressive activity. Journal of inflammation (London, England), 22(1), 48. . PMID: 41199267.

2.) Preston SEJ, Emond A, Pettersson F, Dupéré-Richer D, Abraham MJ, Riva A, Kinal M, Rys RN, Johnson NA, Mann KK, Del Rincón SV, Licht JD, Miller WH (2022 Apr 1). Acquired Resistance to EZH2 Inhibitor GSK343 Promotes the Differentiation of Human DLBCL Cell Lines toward an ABC-Like Phenotype. Molecular cancer therapeutics, 21(4), 511-521. . PMID: 35086959.

3.) Dahabieh MS, Huang F, Goncalves C, Flores González RE, Prabhu S, Bolt A, Di Pietro E, Khoury E, Heath J, Xu ZY, Rémy-Sarrazin J, Mann KK, Orthwein A, Boisvert FM, Braverman N, Miller WH, Del Rincón SV (2022 Mar). Silencing PEX26 as an unconventional mode to kill drug-resistant cancer cells and forestall drug resistance. Autophagy, 18(3), 540-558. . PMID: 34074205.

4.) Bazinet A, Rys RN, Barry A, Greenwood CMT, Young YK, Mendoza A, LaPorta I, Wever CM, Mercier FE, Johnson NA (2021 Oct). A 10-color flow cytometry panel for diagnosis and minimal residual disease in chronic lymphocytic leukemia. Leukemia & lymphoma, 62(10), 2352-2359. doi: 10.1080/10428194.2021.1919658. PMID: 34020575.

5.) Krisna SS, Goncalves C, Gagnon N, Huang F, Plourde D, Miller WH Jr, Fritz JH, Del Rincon SV (2021 Sep 17). Optimized protocol for immunophenotyping of melanoma and tumor-bearing skin from mouse. STAR protocols, 2(3), 100627. . PMID: 34258591.

6.) Huang F, Gonçalves C, Bartish M, Rémy-Sarrazin J, Issa ME, Cordeiro B, Guo Q, Emond A, Attias M, Yang W, Plourde D, Su J, Gimeno MG, Zhan Y, Galán A, Rzymski T, Mazan M, Masiejczyk M, Faber J, Khoury E, Benoit A, Gagnon N, Dankort D, Journe F, Ghanem GE, Krawczyk CM, Saragovi HU, Piccirillo CA, Sonenberg N, Topisirovic I, Rudd CE, Miller WH Jr, Del Rincón SV (2021 Apr 15). Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses. The Journal of clinical investigation, 131(8), . . PMID: 33690225.

7.) Lee J, Villarreal OD, Chen X, Zandee S, Young YK, Torok C, Lamarche-Vane N, Prat A, Rivest S, Gosselin D, Richard S (2020 Dec 29). QUAKING Regulates Microexon Alternative Splicing of the Rho GTPase Pathway and Controls Microglia Homeostasis. Cell reports, 33(13), 108560. doi: 10.1016/j.celrep.2020.108560. PMID: 33378678.

8.) Wu TH, Bolt AM, Chou H, Plourde D, De Jay N, Guilbert C, Young YK, Kleinman CL, Mann KK (2019 Jul 1). Tungsten Blocks Murine B Lymphocyte Differentiation and Proliferation Through Downregulation of IL-7 Receptor/Pax5 Signaling. Toxicological sciences : an official journal of the Society of Toxicology, 170(1), 45-56. doi: 10.1093/toxsci/kfz080. PMID: 30912803.

9.) Guo Q, Li VZ, Nichol JN, Huang F, Yang W, Preston SEJ, Talat Z, Lefrère H, Yu H, Zhang G, Basik M, Gonçalves C, Zhan Y, Plourde D, Su J, Torres J, Marques M, Habyan SA, Bijian K, Amant F, Witcher M, Behbod F, McCaffrey L, Alaoui-Jamali M, Giannakopoulos NV, Brackstone M, Postovit LM, Del Rincón SV, Miller WH Jr (2019 Apr 1). MNK1/NODAL Signaling Promotes Invasive Progression of Breast Ductal Carcinoma In Situ. Cancer research, 79(7), 1646-1657. . PMID: 30659022.

10.) Ahn R, Sabourin V, Bolt AM, Hébert S, Totten S, De Jay N, Festa MC, Young YK, Im YK, Pawson T, Koromilas AE, Muller WJ, Mann KK, Kleinman CL, Ursini-Siegel J (2017 Mar 9). The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression. Nature communications, 8(), 14638. . PMID: 28276425.

11.) Zhao J, Young YK, Fradette J, Eliopoulos N (2015 Jun 15). Melatonin pretreatment of human adipose tissue-derived mesenchymal stromal cells enhances their prosurvival and protective effects on human kidney cells. American journal of physiology. Renal physiology, 308(12), F1474-83. doi: 10.1152/ajprenal.00512.2014. PMID: 25904702.

Description:

Core provides complete flow cytometry analysis and cell sorting services in terms of experimental design, instrumentation, training, technical assistance and scientific guidance from sample preparation to publication.