McLaughlin Research Institute

Contact Info:

Teresa Gunn

1520 23rd St S

Great Falls, MT 59405

https://www.mclaughlinresearch.org/gemma-core-2

Grants and Identifiers:

RRID: RRID:SCR_027045

1P20GM152335-01

Instrumentation:

Services Provided:

Behavioral Phenotyping

Colony Management

Genotyping

Magnetic Resonance Imaging (MRI)

Transgenics

Relevant Publications:

1.) Shaaban D, Seerley A, Crew L, Kaylor C, McElroy S, Guter E, Pounder J, Panter AG (2025 Sep 17). The Impact of Formic Acid Treatment on Brain Tissues for Prion Inactivation. bioRxiv : the preprint server for biology, (), . . ID: 41000621.

2.) Dennaoui R, Rädler PD, Wicker MN, Vistisen K, Ferraiuolo RM, Triplett AA, Shrestha H, Liner TA, Manthey KC, Rui H, Cardiff RD, Gunn TM, Perou CM, Wagner KU (2025 Jul 7). Overexpression of TSG101 causes the development of adenosquamous mammary carcinoma. Breast cancer research : BCR, 27(1), 126. . ID: 40624726.

3.) Casey M, Zou D, Reijo Pera RA, Hensley-McBain T, Cabin DE (2025 Jul 3). Alpha-synuclein null mutation exacerbates the phenotype of a model of Menkes disease in female mice Frontiers in Neuroscience, 19(), 1613171. . PMCID: 12267275.

4.) Crew L, Seerley A, McElroy S, Panter AG (2025 Jul 2). Neurological Tissue Dissection Techniques in Mouse Models for Reproducible Scientific Results: Brain, Spinal Cord, CSF, and Sciatic Nerve bioRxiv, (), 2025.07.01.662633. . PMCID: 12236670.

5.) Walker WP, Ratz-Mitchem ML, Wagner KU, Gunn TM (2025 May 28). Neuronal Deletion of Tumor Susceptibility Gene 101 (Tsg101) Causes Rapid Apoptotic Loss of Hippocampal CA3 Neurons. Biomolecules, 15(6), . . ID: 40563427.

6.) Parashara P, Gao L, Riglos A, Sidhu SB, Lartey D, Marks T, Williams C, Siauw G, Ostrem AIL, Siebold C, Kinnebrew M, Riffle M, Gunn TM, Kong JH (2025 Mar 26). The E3 ubiquitin ligase MGRN1 targets melanocortin receptors MC1R and MC4R via interactions with transmembrane adapters. bioRxiv : the preprint server for biology, (), . . ID: 40196599.

7.) Silvius D, Hurley E, Poitelon Y, Wagner KU, Feltri ML, Gunn TM (2025). Schwann cell deletion of Tumor Susceptibility Gene 101 ( Tsg101 ) in mice results in severe peripheral neuropathy. microPublication biology, 2025(), . . ID: 40061016.

Description:

GEMMA Core offers transgenic and genotyping services, phenotyping, behavioral and motor assessments (including but not limited to Barnes maze, Y-maze, rotarod, DigiGait, open field, novel object, Von Frey mechanical sensitivity, socialization), magnetic resonance imaging (Scintica M3 small animal MRI), mouse colony management services, and specialized mouse compound administration (including stereotaxic intracerebral ventricular injections) and dissection services (including blood collection, CSF collection, and specific brain region dissections). Consultation and training is also available.