Pennsylvania State University

Contact Info:

Tatiana Laremore

https://www.huck.psu.edu/core-facilities/proteomics-and-mass-spectrometry-core-facility

Grants and Identifiers:

RRID: RRID:SCR_024462

Instrumentation:

Services Provided:

Relevant Publications:

1.) Kulkarni S, Smith C, Akinniyi OT, Giardine BM, Keller CA, Arnaoutov A, Reese JC (2025 Oct 27). Auxin-induced depletion of human CCR4-NOT subunits reveals opposing functions of CNOT1 and CNOT4 in mRNA metabolism The Journal of Biological Chemistry, 301(12), 110862. . PMCID: 12682128.

2.) Dewing SM, Showalter SA (2025 Oct). Probing Enzymatic Acetylation Events in Real Time With NMR Spectroscopy: Insights Into Acyl-Cofactor Dependent p300 Modification of Histone H4. Proteins, 93(10), 1837-1847. . PMID: 40452297.

3.) Fekete FJ, Weinert EE (2025 Sep 9). Identifying bacterial heme sensor protein interacting partners under varying oxygen tensions using proximity labeling. Journal of inorganic biochemistry, 274(), 113067. doi: 10.1016/j.jinorgbio.2025.113067. PMID: 40946585.

4.) Zhang H, Yao Y, Wang X, Tao Y, Yang H, Wang Y, Liu M, Feric M, Zhou R (2025 Jul 23). FLEXTAG: A Small and Self-renewable Protein Labeling System for Anti-fading Multicolor Super-resolution Imaging bioRxiv, (), 2025.07.19.665678. . PMCID: 12330666.

5.) Saha P, van der Vlies AJ, Aditya T, Dighe K, Hicks SD, Pan D (2025 Jun 15). Anti-miR oligo-mediated detection of human salivary microRNAs for mild traumatic brain injury. Biosensors & bioelectronics, 278(), 117333. doi: 10.1016/j.bios.2025.117333. PMID: 40056568.

6.) Akinniyi OT, Sebastian A, Kulkarni S, Hribal MM, Keller CA, Giardine BM, Albert I, Reese JC (2025 Apr 8). The DNA damage response and RNA Polymerase II regulator Def1 has posttranscriptional functions in the cytoplasm. bioRxiv : the preprint server for biology, (), . . PMID: 39463967.

7.) Kulkarni S, Morrissey A, Sebastian A, Giardine B, Smith C, Akinniyi OT, Keller CA, Arnaoutov A, Albert I, Mahony S, Reese JC (2024 Nov 25). Human CCR4-NOT globally regulates gene expression and is a novel silencer of retrotransposon activation. bioRxiv : the preprint server for biology, (), . . PMID: 39314347.

8.) Dewing SM, Phan TM, Kraft EJ, Mittal J, Showalter SA (2024 Oct 22). Acetylation-Dependent Compaction of the Histone H4 Tail Ensemble The Journal of Physical Chemistry. B, 128(43), 10636-10649. . PMCID: 11533190.

Description:

Facility offers highly sensitive and accurate mass spectrometry analysis, including identification and quantitation of proteins by liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS-MS) or by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-TOF-MS).