Fred Hutch Cancer Center

Contact Info:

Shared Resources Administration

1100 Fairview Ave N.

CD-101

Seattle, WA 98109

https://www.fredhutch.org/en/research/shared-resources/core-facilities/preclinical-modeling-core-lab.html

Grants and Identifiers:

RRID: RRID:SCR_022617

P30CA015704

Instrumentation:

Services Provided:

CRISPR

Transgenics

Xenograft / Xenotransplantation

Relevant Publications:

1.) Rominger MC, O’Brien S, Gupta S, Moorthi S, McSharry M, Kamlapurkar S, Lowe AR, Waldum A, Lo A, Duke F, Wu F, Headley MB, Cromwell E, Glabman R, Koehne A, Berger AH (2025 Sep 24). Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state Cell reports, 44(10), 116185. . PMCID: 12646131.

2.) Riley AK, Grant M, Snell A, Cromwell E, Vichas A, Moorthi S, Rominger C, Modukuri SP, Urisman A, Castel P, Wan L, Berger AH (2024 Jul 14). The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes iScience, 27(8), 110499. . PMCID: 11332844.

Description:

Supports development and maintenance of preclinical mouse models, including patient derived xenografts, cell line xenografts and genetically engineered mouse models