Fred Hutch Cancer Center
Shared Resources Administration
1100 Fairview Ave N.
CD-101
Seattle, WA 98109
https://www.fredhutch.org/en/research/shared-resources/core-facilities/preclinical-modeling-core-lab.html
RRID: RRID:SCR_022617
Other Citation IdentifiersP30CA015704
CRISPR
Transgenics
Xenograft / Xenotransplantation
1.) Rominger MC, O’Brien S, Gupta S, Moorthi S, McSharry M, Kamlapurkar S, Lowe AR, Waldum A, Lo A, Duke F, Wu F, Headley MB, Cromwell E, Glabman R, Koehne A, Berger AH (2025 Sep 24). Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state Cell reports, 44(10), 116185. . PMCID: 12646131.
2.) Riley AK, Grant M, Snell A, Cromwell E, Vichas A, Moorthi S, Rominger C, Modukuri SP, Urisman A, Castel P, Wan L, Berger AH (2024 Jul 14). The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes iScience, 27(8), 110499. . PMCID: 11332844.
Supports development and maintenance of preclinical mouse models, including patient derived xenografts, cell line xenografts and genetically engineered mouse models