Fred Hutch Cancer Center

Contact Info:

Shared Resources Administration

1100 Fairview Ave N.

CD-101

Seattle, WA 98109

https://www.fredhutch.org/en/research/shared-resources/core-facilities/preclinical-imaging.html

Grants and Identifiers:

RRID: RRID:SCR_022616

P30CA015704

Instrumentation:

Other Equipment

Vevo 2100 Ultrasound Perkin Elmer IVIS Spectrum In Vivo Imaging Systems 7T Dry Magnet MRI Multiphoton Microscope Quantum GX2 micro-CT EchoMRI

Services Provided:

Clinical Imaging - Small Animal (luminescence/fluorescence)

Clinical Imaging - Small Animal (X-ray, Ultrasound, microCAT, MRI)

Magnetic Resonance Imaging (MRI)

Microscopy

Relevant Publications:

1.) Mihalas AB, Mitchell K, Arora S, O’Connor SA, Patel AP, Plaisier CL, Paddison PJ (2025 Oct 6). Characterization of quiescent subpopulations and proliferative compartments in glioblastoma bioRxiv, (), 2025.10.03.680278. . PMCID: 12632554.

2.) Rominger MC, O’Brien S, Gupta S, Moorthi S, McSharry M, Kamlapurkar S, Lowe AR, Waldum A, Lo A, Duke F, Wu F, Headley MB, Cromwell E, Glabman R, Koehne A, Berger AH (2025 Sep 24). Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state Cell reports, 44(10), 116185. . PMCID: 12646131.

3.) Mihalas AB, Arora S, O’Connor SA, Feldman HM, Cucinotta CE, Mitchell K, Bassett J, Kim D, Jin K, Hoellerbauer P, Delegard J, Ling M, Jenkins W, Kufeld M, Corrin P, Carter L, Tsukiyama T, Aronow B, Plaisier CL, Patel AP, Paddison PJ (2025 May 9). KAT5 regulates neurodevelopmental states associated with G0-like populations in glioblastoma Nature Communications, 16(), 4327. . PMCID: 12064679.

4.) Schmid S, Russell ZR, Yamashita AS, West ME, Parrish AG, Walker J, Rudoy D, Yan JZ, Quist DC, Gessesse BN, Alvinez N, Cimino PJ, Kumasaka DK, Parchment RE, Holland EC, Szulzewsky F (2024 Mar 26). ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse models bioRxiv, (), 2024.03.13.584849. . PMCID: 10979979.

Description:

Provides in vivo imaging technology and infrastructure to support basic and preclinical research. Offers diverse array of imaging modalities, including ultrasound and optical imaging, MRI, micro-CT and multiphoton microscopy.