Fred Hutch Cancer Center
Shared Resources Administration
1100 Fairview Ave N.
CD-101
Seattle, WA 98109
https://www.fredhutch.org/en/research/shared-resources/core-facilities/comparative-medicine.html
RRID: RRID:SCR_022610
Other Citation IdentifiersP30CA015704
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1.) Liu Y, Zhang Z, Tao Y, Rahgav L, Gray-Gaillard S, Hussaini Y, Pan M, Shamber J, Kwak J, Park SL, Cramer J, Stoltz R, Patria J, Swanger J, Liu K, Sannigrahi MK, Houghton AM, Rodriguez CP, Carey RM, Brody R, Rajasekaran K, Weinstein G, Linette GP, Carreno BM, Painter MM, Wherry EJ, Clurman B, Basu D, Diab A (2026 Mar 17). Therapeutic scheduling of WEE1 inhibition preserves T cell function and promotes immune control of HPV⁺ tumors. bioRxiv : the preprint server for biology, (), . . PMCID: 13015432.
2.) Ramsey EL, Dobersch S, Freie B, Hong NH, Wu X, Kugel S, Eisenman RN, Carroll PA (2026 Mar 10). MondoA mediates transcriptional coordination between the MYC network and the integrated stress response in pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America, 123(10), e2524659123. . PMCID: 12974408.
3.) Chhan CB, Lang K, Davis AR, Wan YH, Aldridge NT, Kher G, Scharffenberger SC, Hardy SR, Iureniev R, Giltiay NV, Edwards KR, Radtke S, Kiem HP, Pancera M, McGuire AT (2026 Feb 17). Transgenic mouse-derived human monoclonal antibodies targeting EBV gp350 and gp42 provide basis for therapeutic development. Cell reports. Medicine, 7(2), 102618. . PMCID: 12923964.
4.) Zhang S, Tang TH, Kinsella S, Mazziotta F, Schweizer MT, McAfee MS, Munkhbat A, Su Y, Voillet V, Martin LE, Smith CW, Asano Y, Hailemariam M, Bakhtiari J, Lee B, Yeung C, Chen H, Rizzi AM, Chen DG, Furiya K, Horst N, Zhang T, Le P, McKenna K, Oda SK, Rongvaux A, Greenberg PD, Schmitt TM, Chapuis AG (2026 Jan 3). A CD8αβ co-receptor modified to contain an intracellular CD28 signaling tail enhances TCR-engineered T cell function independent of solid-tumor-associated co-stimulatory ligands. Nature communications, 17(1), 753. . PMCID: 12820041.
5.) McCutcheon KR, Wu J, Ozdemir YC, McKinney BJ, Srinivasan S, Itokawa A, Newsom OJ, Vigil A, Fox DB, Sullivan LB, Alvarez JV (2025 Nov 17). Recurrent Breast Cancer Cells Depend on De novo Pyrimidine Biosynthesis to Suppress Ferroptosis bioRxiv, (), 2025.11.17.688927. . PMCID: 12667778.
6.) Avanessian SC, van den Bijgaart RJ, Chew NW, Supper VM, Tang TT, Zhang Y, Zhao YQ, Abe K, Gauthier J, Barry KC (2025 Oct 13). IL-2/IL-15 signaling induces NK cell production of FLT3LG augmenting anti-PD-1 immunotherapy Cancer immunology research, (), 10.1158/2326-6066.CIR-24-1259. . PMCID: 12582536.
7.) Ramsey EL, Dobersch S, Freie B, Hong NH, Wu X, Kugel S, Eisenman RN, Carroll PA (2025 Sep 8). MondoA mediates transcriptional coordination between the MYC network and the integrated stress response in pancreatic ductal adenocarcinoma bioRxiv, (), 2025.09.03.674106. . PMCID: 12439892.
8.) Choe M, Kirkey D, Lira I, Hawkins G, Blankenfeld M, Menashe S, Ries RE, Wrightson B, Root C, McKay CN, Peplinski JH, Glabman R, Davis LE, Malhotra SV, Gorlick R, Loggers ET, Meshinchi S (2025 Sep 1). Preclinical Evaluation of Folate Receptor-α Chimeric Antigen Receptor T Cells Exhibits Highly Efficient Antitumor Activity against Osteosarcoma. Cancer research communications, 5(9), 1701-1713. . PMCID: 12455178.
9.) Shenoy MK, Rico DM, Lorant AK, Touré H, Gordon S, Milburn LJ, Schwensen JS, Cabán ME, Koch MA (2025 Aug 14). Breast milk IgG engages the mouse neonatal immune system to instruct responses to gut antigens. Science (New York, N.Y.), 389(6761), eado5294. doi: 10.1126/science.ado5294. PMID: 40811558.
10.) Wilcox-King A, Wan YH, Scharffenberger SC, Chhan CB, Davis AR, Homad LJ, Seydoux E, MacPhee KJ, Siddaramaiah LK, Melo M, Dosenovic P, Irvine DJ, Hyrien O, Stamatatos L, McGuire AT (2025 Aug 5). Priming VRC01-precursor B cells with non-envelope immunogens disfavors boosting with HIV-1 envelope NPJ Vaccines, 10(), 185. . PMCID: 12325944.
11.) Choo S, Tong AH, Fields E, Mack HM, Humbert O, Radtke S, Kiem HP (2025 Jul 17). A rescue fanconi anemia humanized mouse model with endogenous FA mutation and high human hematopoietic stem cell chimerism Molecular Therapy. Methods & Clinical Development, 33(3), 101528. . PMCID: 12355547.
12.) Garcia NMG, Becerra JN, Srinivasan S, McKinney BJ, DiMarco AV, Wu F, Fitzgibbon M, Alvarez JV (2025 May 1). APOBEC3 Activity Promotes the Survival and Evolution of Drug-Tolerant Persister Cells during EGFR Inhibitor Resistance in Lung Cancer. Cancer research communications, 5(5), 825-840. . PMID: 40323013.
13.) Vick SC, Domenjo-Vila E, Frutoso M, Glabman RA, Warrier LS, Hughes SM, Kirby AC, Fialkow MF, Hladik F, Prlic M, Lund JM (2025 Apr 9). Mucosal tissue NK cells tune their function between optimal anti-pathogen activity and tissue protection bioRxiv, (), 2025.04.04.647286. . PMCID: 12026740.
14.) Rominger MC, Gupta S, Moorthi S, McSharry M, Kamlapurkar S, O’Brien S, Waldum A, Lo A, Duke F, Lowe AR, Cromwell E, Glabman R, Koehne A, Berger AH (2024 Nov 12). Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state bioRxiv, (), 2024.11.11.623044. . PMCID: 11601272.
15.) Freie B, Ibrahim AH, Carroll PA, Bronson RT, Augert A, MacPherson D, Eisenman RN (2024 Sep 24). MAX inactivation deregulates the MYC network and induces neuroendocrine neoplasia in multiple tissues bioRxiv, (), 2024.09.21.614255. . PMCID: 11463667.
16.) Frank S, Persse T, Coleman I, Bankhead A III, Li D, De-Sarkar N, Wilson D, Rudoy D, Vashisth M, Galipeau P, Yang M, Hanratty B, Dumpit R, Morrissey C, Corey E, Montgomery RB, Haffner MC, Pritchard C, Vasioukhin V, Ha G, Nelson PS (2024 Jul 19). Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies bioRxiv, (), 2024.07.16.603734. . PMCID: 11275783.
17.) Garcia NM, Becerra JN, McKinney BJ, DiMarco AV, Wu F, Fitzgibbon M, Alvarez JV (2023 Jul 3). APOBEC3 activity promotes the survival and evolution of drug-tolerant persister cells during acquired resistance to EGFR inhibitors in lung cancer bioRxiv, (), 2023.07.02.547443. . PMCID: 10350004.
18.) (). PMCID: 12947312.
The Comparative Medicine shared resource provides a variety of research support services. All our facilities are fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC) International and comply with all U.S. Department of Agriculture, Public Health Service, Washington state and local area regulations
