Fred Hutch Cancer Center

Contact Info:

Shared Resources Administration

1100 Fairview Ave N.

CD-101

Seattle, WA 98109

https://www.fredhutch.org/en/research/shared-resources/core-facilities/comparative-medicine.html

Grants and Identifiers:

RRID: RRID:SCR_022610

P30CA015704

Instrumentation:

Services Provided:

Animal Husbandry

Colony Management

Training

Veterinary Pathology

Veterinary Services

Relevant Publications:

1.) Avanessian SC, van den Bijgaart RJ, Chew NW, Supper VM, Tang TT, Zhang Y, Zhao YQ, Abe K, Gauthier J, Barry KC (2025 Oct 13). IL-2/IL-15 signaling induces NK cell production of FLT3LG augmenting anti-PD-1 immunotherapy Cancer immunology research, (), 10.1158/2326-6066.CIR-24-1259. . PMCID: 12582536.

2.) Ramsey EL, Dobersch S, Freie B, Hong NH, Wu X, Kugel S, Eisenman RN, Carroll PA (2025 Sep 8). MondoA mediates transcriptional coordination between the MYC network and the integrated stress response in pancreatic ductal adenocarcinoma bioRxiv, (), 2025.09.03.674106. . PMCID: 12439892.

3.) Wilcox-King A, Wan YH, Scharffenberger SC, Chhan CB, Davis AR, Homad LJ, Seydoux E, MacPhee KJ, Siddaramaiah LK, Melo M, Dosenovic P, Irvine DJ, Hyrien O, Stamatatos L, McGuire AT (2025 Aug 5). Priming VRC01-precursor B cells with non-envelope immunogens disfavors boosting with HIV-1 envelope NPJ Vaccines, 10(), 185. . PMCID: 12325944.

4.) Choo S, Tong AH, Fields E, Mack HM, Humbert O, Radtke S, Kiem HP (2025 Jul 17). A rescue fanconi anemia humanized mouse model with endogenous FA mutation and high human hematopoietic stem cell chimerism Molecular Therapy. Methods & Clinical Development, 33(3), 101528. . PMCID: 12355547.

5.) Vick SC, Domenjo-Vila E, Frutoso M, Glabman RA, Warrier LS, Hughes SM, Kirby AC, Fialkow MF, Hladik F, Prlic M, Lund JM (2025 Apr 9). Mucosal tissue NK cells tune their function between optimal anti-pathogen activity and tissue protection bioRxiv, (), 2025.04.04.647286. . PMCID: 12026740.

6.) Rominger MC, Gupta S, Moorthi S, McSharry M, Kamlapurkar S, O’Brien S, Waldum A, Lo A, Duke F, Lowe AR, Cromwell E, Glabman R, Koehne A, Berger AH (2024 Nov 12). Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state bioRxiv, (), 2024.11.11.623044. . PMCID: 11601272.

7.) Freie B, Ibrahim AH, Carroll PA, Bronson RT, Augert A, MacPherson D, Eisenman RN (2024 Sep 24). MAX inactivation deregulates the MYC network and induces neuroendocrine neoplasia in multiple tissues bioRxiv, (), 2024.09.21.614255. . PMCID: 11463667.

8.) Frank S, Persse T, Coleman I, Bankhead A III, Li D, De-Sarkar N, Wilson D, Rudoy D, Vashisth M, Galipeau P, Yang M, Hanratty B, Dumpit R, Morrissey C, Corey E, Montgomery RB, Haffner MC, Pritchard C, Vasioukhin V, Ha G, Nelson PS (2024 Jul 19). Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies bioRxiv, (), 2024.07.16.603734. . PMCID: 11275783.

9.) Garcia NM, Becerra JN, McKinney BJ, DiMarco AV, Wu F, Fitzgibbon M, Alvarez JV (2023 Jul 3). APOBEC3 activity promotes the survival and evolution of drug-tolerant persister cells during acquired resistance to EGFR inhibitors in lung cancer bioRxiv, (), 2023.07.02.547443. . PMCID: 10350004.

Description:

The Comparative Medicine shared resource provides a variety of research support services. All our facilities are fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC) International and comply with all U.S. Department of Agriculture, Public Health Service, Washington state and local area regulations.