Core provides services including preparation of research tissue specimens for microscopic investigation with imaging capabilities for brighfield and fluorescent microscopy. Offers preparation tissue specimens for Histological sectioning utilizing both frozen and paraffin embedding techniques, preparation of mounted sections on glass slides. Facility maintains microtomes and cryostats for the preparation of tissue sections and houses several high end fluorescent microscopy systems, including the Leica Stellaris 8 tau-STED Super Resolution Microscope, the Nikon A1R+ HD Confocal Microscope,and the Nikon Ti2 HCA Inverted Fluorescence Microscope. Core also provides access to the Spatial Biology Platforms: Akoya PhenoCycler Fusion 2.0, 10x Genomics Visium and 10x Genomics Xenium.

Research Overview

The Cell and Cell Products Fermentation Facility at Waksman Institute has a multi-client base and produces a wide range of bulk biologics including: antimicrobials, cosmetic substrates, flavors/fragrances, biopesticides/bioherbicides and plasmid-derived proteins, enzymes, growth factors and diagnostics to name just a few. We are equipped to handle most requests with the exceptions: pathogenic or opportunistic organisms and mammalian and insect cell lines. The facility is designated BL2-LS. Our bioreactor volumes range from 15 to 800L maximum operating volumes. All projects are conducted under CDA/NDA agreements, which limit discussion of specific company or projects. We operate as a not-for-profit, fee-for-service, self-supportive lab and receive no direct funding from state or federal sources.

MISSION STATEMENT

The primary goal has been to provide affordable fermentation services to a highly diverse client base which includes but not limited to the academia, pharmaceutical and biotech industries. The facility welcomes academia, start-up firms, small research operations, and larger companies who find their in-house facilities overtaxed. The facility meets BL2-LS containment requirements, and is comprised of four contiguous operation units:

Material Preparation Laboratory
Fermentation In-Process/Computer Control
Product Recovery
Analytical Services

With the advantage of having the world\\\'s pharmaceutical industry in its backyard and being situated at a University that offers a diverse set of core facilities and equipment for collaborative use, a productive climate of industrial liaison has been the historical legacy of the facility.

We provide NGS services for research and clinical samples in a CLIP and CAP accredited laboratory.
Our service include consultation, sample processing, sequencing and data analysis , as well as interpretation and reporting