The Mouse Biology Shared Resource (MBSR) provides unique, sophisticated, and comprehensive knockout, transgenic, and humanized murine cancer models and related services for advancing translational cancer research. Additionally, the MBSR offers services to enhance the use of existing mouse models or to facilitate the development of new mouse models for cancer research, including genetic alteration (e.g., CRISPR/Cas9-mediated gene targeting, transgenesis), surgical manipulation (e.g., patient-derived xenografts (PDX), cell-derived allografts (CDA) and xenografts (CDX)), and environmental challenges (e.g., diet, chemotherapeutic agents).

The MBSR has over 26 years of experience creating and studying genetically modified, PDX and other types of mouse models for use in cancer studies.

It has the ability to produce a wide range of allele-specific mouse models to help you achieve your research objectives. The MBSR also offers innovative technologies to phenotype mouse models that mimic human conditions.

The Molecular Pharmacology and Chemical Biology Shared Resource (MPCBSR) provides essential and a broad spectrum of services for the assessment of new therapeutics, including high-quality collection and management of clinical trial specimens and determination of clinical PK/PD and potential drug-drug interactions (DDI), pharmacological studies on novel therapeutics in preclinical models, including DM/PK/PD, on-target mechanisms, biomarkers, and combination effects, and chemical synthesis of new compounds and drug delivery nanomaterials for improved therapy.

The Molecular Pharmacology and Chemical Biology Shared Resource is part of UC Davis Health Comprehensive Cancer Center.