Our mission is to support our users throughout their cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) projects, including experimental design, sample optimization, and final data acquisition.

The MPI-NAT Cryo-EM Facility provides access to high-end infrastructure for single-particle cryo-EM and cryo-ET. We are equipped to support all flavours of single-particle cryo-EM (vitreous ice, graphene and carbon support films) and have broad experience in advising on biochemical sample optimization (detergents, additives, crosslinking). In addition, we offer equipment and support for cryo-ET sample preparation (single side blotting, manual blotting, stereo microscopes) as well as correlative workflows (CLEM), FIB-milling (including automation) and state-of-the art tomography data acquisition schemes (dose-symmetric tomography, PACE-tomography).