The Gastrointestinal Epithelium Modeling (GEM) Core is a component of the GEM Program - a collaborative research effort focused on accelerating discovery and innovation using patient tissue-derived organoids. GEM Core staff generate and maintain a living biobank of tissue-derived organoids with matched original tissue and blood specimens and provide access to specialized training, protocols, and reagents.

The CHOP Biorepository Resource Center (BioRC) serves to accession, process, store, and manage distribution of research biospecimens for biobanking efforts. We offer specimen processing, and RNA and DNA extraction services.

Core has established quality controlled protocols to quantitatively analyze whole proteomes, phosphoproteomes, ubiquitylomes, and/or lysine acetylomes at deep level through process of serial enrichment.