The imaging core provides investigators with access to electron, confocal, TIRF and fluorescence microscopy equipment. Equipment housed in the facility includes an Hitachi 7500 TEM, an Hitachi 4700 field emission SEM, a Zeiss 510 META confocal microscope system on an Axiovert 200 inverted fluorescence microscope, a Zeiss ConfoCor2 fluorescence correlation spectroscopy (FCS) system , an Olympus FV300 confocal microscope on an Olympus IX70 inverted fluorescence microscope, an Olympus FV1000 MPE multiphoton system for intravital microscopy, an Olympus IX83 cellTIRF microscope, a Nikon Eclipse i80 upright fluorescence microscope and a Nikon TE300 inverted fluorescence microscope. Computer workstations and equipment for live cell imaging are also available. Applications using this equipment include TEM, SEM, spectral imaging, multicolor confocal/fluorescence microscopy, FRET, FRAP, FLIP, FCS, TIRF, ratiometric calcium and biosensor imaging and standard fluorescence imaging.