New York University School of Medicine

Contact Info:

Brianna Alvarez

New York, NY 10016

https://med.nyu.edu/research/scientific-cores-shared-resources/center-biospecimen-research-development

Grants and Identifiers:

RRID: RRID:SCR_017930

Instrumentation:

Other Equipment

Our Research Support Services Include: Digital Pathology: digital slides images enable researchers to instantly view, evaluate and annotate slide images. Creating a digital slide library protects tissue resources for future research. Our APERIO scanner by Leica offers high-quality digital imaging, is user friendly and is the most common whole slide scanner in clinical practice. Tissue microarrays (TMAs): CBRD creates tumor and tissue specific TMA from high quality formalin-fixed paraffin embedded tissue samples; cores are selected by qualified Board certified Pathologists. Map/datasheet includes H&E images and detailed pathology reports. Sections of TMAs are available for the research community. Nucleic Acids extraction: High quality and yield of DNA or RNA is critical to ensure the success of assays such as sequencing, genotyping or gene expression. Our QIASymphony SP enables sample preparation of DNA and RNA from a variety of specimens such as whole blood, saliva, blood-spots, fresh and frozen tissue (including FFPE). Biobanks development: CBRD offers biospecimen procurement, processing, quality control, storing, and distributing for future research. Coordinating the collection and processing of fresh tissue for research projects. ​​

Services Provided:

Microarray

Nucleic Acid Extraction

Relevant Publications:

1.) Berger S, Seeger F, Yu TY, Aydin M, Yang H, Rosenblum D, Guenin-Macé L, Glassman C, Arguinchona L, Sniezek C, Blackstone A, Carter L, Ravichandran R, Ahlrichs M, Murphy M, Pultz IS, Kang A, Bera AK, Stewart L, Garcia KC, Naik S, Spangler JB, Beigel F, Siebeck M, Gropp R, Baker D (2024 Aug 8). Preclinical proof of principle for orally delivered Th17 antagonist miniproteins. Cell, 187(16), 4305-4317.e18. . PMID: 38936360.

2.) Wise DR, Pachynski RK, Denmeade SR, Aggarwal RR, Deng J, Febles VA, Balar AV, Economides MP, Loomis C, Selvaraj S, Haas M, Kagey MH, Newman W, Baum J, Troxel AB, Griglun S, Leis D, Yang N, Aranchiy V, Machado S, Waalkes E, Gargano G, Soamchand N, Puranik A, Chattopadhyay P, Fedal E, Deng FM, Ren Q, Chiriboga L, Melamed J, Sirard CA, Wong KK (2024 Feb 10). A Phase 1/2 multicenter trial of DKN-01 as monotherapy or in combination with docetaxel for the treatment of metastatic castration-resistant prostate cancer (mCRPC). Prostate cancer and prostatic diseases, (), . doi: 10.1038/s41391-024-00798-z. PMID: 38341461.

3.) Chang SH, Mezzano-Robinson V, Zhou H, Moreira A, Pillai R, Ramaswami S, Loomis C, Heguy A, Tsirigos A, Pass HI (2023 Oct 27). Digital spatial profiling to predict recurrence in grade 3 stage I lung adenocarcinoma. The Journal of thoracic and cardiovascular surgery, (), . pii: S0022-5223(23)01004-8. doi: 10.1016/j.jtcvs.2023.10.047. PMID: 37890657.

4.) You J, Osea J, Mendoza S, Shiomi T, Gallego E, Pham B, Kim A, Sinay-Smith A, Zayas Z, Neto AG, Boytard L, Chiriboga L, Cotzia P, Moreira AL (2023 Oct 1). Automated and robust extraction of genomic DNA from various leftover blood samples. Analytical biochemistry, 678(), 115271. doi: 10.1016/j.ab.2023.115271. PMID: 37543277.

5.) Dou Y, Katsnelson L, Gritsenko MA, Hu Y, Reva B, Hong R, Wang YT, Kolodziejczak I, Lu RJ, Tsai CF, Bu W, Liu W, Guo X, An E, Arend RC, Bavarva J, Chen L, Chu RK, Czekański A, Davoli T, Demicco EG, DeLair D, Devereaux K, Dhanasekaran SM, Dottino P, Dover B, Fillmore TL, Foxall M, Hermann CE, Hiltke T, Hostetter G, Jędryka M, Jewell SD, Johnson I, Kahn AG, Ku AT, Kumar-Sinha C, Kurzawa P, Lazar AJ, Lazcano R, Lei JT, Li Y, Liao Y, Lih TM, Lin TT, Martignetti JA, Masand RP, Matkowski R, McKerrow W, (2023 Sep 11). Proteogenomic insights suggest druggable pathways in endometrial carcinoma. Cancer cell, 41(9), 1586-1605.e15. . PMID: 37567170.

Description:

NYU School of Medicine’s Center for Biospecimen Research and Development was launched as a partnership between the Office of Science and Research and the Department of Pathology. Our center’s mission is to drive scientific discovery through the use of human specimens. We help our investigators facilitate translational research, match human specimen resources to scientific needs, foster multi-investigator collaborative projects, and catalyze scientific innovation. Our center is also focused on increasing clinical trial support for investigator-initiated trials, improving researcher access to existing biospecimen resources, and enhancing institution-wide tissue-banking efforts and capacity. Another priority is to implement a campus-wide policy for human biospecimen collection and storage to ensure regulatory compliance.