New York University School of Medicine

Contact Info:

Brianna Alvarez

New York, NY 10016

https://med.nyu.edu/research/scientific-cores-shared-resources/genome-technology-center

Grants and Identifiers:

RRID: RRID:SCR_017929

Instrumentation:

Services Provided:

DNA Analysis

Genomics

Microarray

Sequencing - DNA Sequencing

Sequencing - Next Generation Sequencing (NGS)

Relevant Publications:

1.) Tu NH, Inoue K, Lewis PK, Khan A, Hwang JH, Chokshi V, Dabovic BB, Selvaraj S, Bhattacharya A, Dubeykovskaya Z, Pinkerton NM, Bunnett NW, Loomis CA, Albertson DG, Schmidt BL (2023 Jun 21). Calcitonin Related Polypeptide Alpha Mediates Oral Cancer Pain Cells, 12(13), 1675. . PMCID: 10341289.

2.) Cheng P, Zhao X, Katsnelson L, Camacho-Hernandez EM, Mermerian A, Mays JC, Lippman SM, Rosales-Alvarez RE, Moya R, Shwetar J, Grun D, Fenyo D, Davoli T (2022 Sep 21). Proteogenomic analysis of cancer aneuploidy and normal tissues reveals divergent modes of gene regulation across cellular pathways eLife, 11(), e75227. . PMCID: 9491860.

3.) Coleman KE, Yin Y, Lui SKL, Keegan S, Fenyo D, Smith DJ, Rothenberg E, Huang TT (2022 Apr 1). USP1-trapping lesions as a source of DNA replication stress and genomic instability. Nature communications, 13(1), 1740. doi: 10.1038/s41467-022-29369-3. PMID: 35365626.

4.) Hu HL, Srinivas KP, Wang S, Chao MV, Lionnet T, Mohr I, Wilson AC, Depledge DP, Huang TT (2022 Feb 3). Single-cell transcriptomics identifies Gadd45b as a regulator of herpesvirus-reactivating neurons. EMBO reports, 23(2), e53543. doi: 10.15252/embr.202153543. PMID: 34842321.

5.) Huang HW, Ryoo HD (2021 Oct). Drosophila fabp is required for light-dependent Rhodopsin-1 clearance and photoreceptor survival. PLoS genetics, 17(10), e1009551. doi: 10.1371/journal.pgen.1009551. PMID: 34714826.

6.) Pankiewicz JE, Lizińczyk AM, Franco LA, Diaz JR, Martá-Ariza M, Sadowski MJ (2021 Sep 26). Absence of Apolipoprotein E is associated with exacerbation of prion pathology and promotes microglial neurodegenerative phenotype. Acta neuropathologica communications, 9(1), 157. doi: 10.1186/s40478-021-01261-z. PMID: 34565486.

7.) Burgess HM, Depledge DP, Thompson L, Srinivas KP, Grande RC, Vink EI, Abebe JS, Blackaby WP, Hendrick A, Albertella MR, Kouzarides T, Stapleford KA, Wilson AC, Mohr I (2021 Jul 1). Targeting the m⁶A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication. Genes & development, 35(13), 1005-1019. . PMID: 34168039.

8.) Rubio RM, Depledge DP, Bianco C, Thompson L, Mohr I (2018 Dec 1). RNA m⁶ A modification enzymes shape innate responses to DNA by regulating interferon β. Genes & development, 32(23), 1472-1484. . PMID: 30463905.

Description:

NYULMC's Genome Technology Center provides an environment that facilitates crosstalk between researchers from different fields such as biology, chemistry and bioinformatics. The NYULMC Genome Technology Center provides access to highly specialized equipment and unique expertise, including: 1. high-throughput genomic and computational methodologies, such as gene and microRNA expression profiling and functional genomics experiments (protein:chromatin DNA interactions) 2. genome-wide array- and quantitative PCR-based expression profiling 3. high-capacity chromatin structure studies (ChIP-on-chip) 4. DNA analyses (whole genome SNP genotyping, high-resolution chromosome copy number analysis, high-capacity quantitative PCR and pyrosequencing) 5. consultations and 1-on-1 assistance with issues of experimental design 6. storage, annotation, processing, and analysis of data 7. educational activities to assist the user community with various aspects of genomics, bioinformatics and other fields of modern biology