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Experimental Pathology Laboratory (ExpPath)

New York University School of Medicine

Contact Info:

Cytometry and Cell Sorting Laboratory Editor

New York University

550 First Avenue Medical Science Building Rm 379

New York, NY 10016

https://med.nyu.edu/research/scientific-cores-shared-resources/experimental-pathology-research-laboratory

Grants and Identifiers:

RRID: RRID:SCR_017928

Other Citation Identifiers

P30CA016087

Instrumentation:

Services Provided:

Histology

Image Processing And Analysis

Immunohistochemistry

Relevant Publications:

1.) Ortigoza MB, Mobini CL, Rocha HL, Bartlett S, Loomis CA, Weiser JN (2024 Jan 11). Inhibiting influenza virus transmission using a broadly acting neuraminidase that targets host sialic acids in the upper respiratory tract mBio, 15(2), e02203-23. . PMCID: 10865980.


2.) Zhang W, Golynker I, Brosh R, Fajardo A, Zhu Y, Wudzinska AM, Ordoñez R, Ribeiro-dos-Santos AM, Carrau L, Damani-Yokota P, Yeung ST, Khairallah C, Vela Gartner A, Chalhoub N, Huang E, Ashe HJ, Khanna KM, Maurano MT, Kim SY, tenOever BR, Boeke JD (2023 Nov 1). Mouse genome rewriting and tailoring of three important disease loci Nature, 623(7986), 423-431. . PMCID: 10632133.


3.) Zhang W, Golynker I, Brosh R, Fajardo A, Zhu Y, Wudzinska AM, Ordoñez R, Ribeiro-Dos-Santos AM, Carrau L, Damani-Yokota P, Yeung ST, Khairallah C, Vela Gartner A, Chalhoub N, Huang E, Ashe HJ, Khanna KM, Maurano MT, Kim SY, tenOever BR, Boeke JD (2023 Nov). Mouse genome rewriting and tailoring of three important disease loci. Nature, 623(7986), 423-431. . PMID: 37914927.


4.) Ortigoza MB, Mobini CL, Rocha HL, Bartlett S, Loomis CA, Weiser JN (2023 Aug 15). Targeting host sialic acids in the upper respiratory tract with a broadly-acting neuraminidase to inhibit influenza virus transmission. bioRxiv : the preprint server for biology, (), . . PMID: 37398388.


5.) Noval MG, Spector SN, Bartnicki E, Izzo F, Narula N, Yeung ST, Damani-Yokota P, Dewan MZ, Mezzano V, Rodriguez-Rodriguez BA, Loomis C, Khanna KM, Stapleford KA (2023 Aug 3). MAVS signaling is required for preventing persistent chikungunya heart infection and chronic vascular tissue inflammation Nature Communications, 14(), 4668. . PMCID: 10400619.


6.) Noval MG, Spector SN, Bartnicki E, Izzo F, Narula N, Yeung ST, Damani-Yokota P, Dewan MZ, Mezzano V, Rodriguez-Rodriguez BA, Loomis C, Khanna KM, Stapleford KA (2023 Aug 3). MAVS signaling is required for preventing persistent chikungunya heart infection and chronic vascular tissue inflammation. Nature communications, 14(1), 4668. . PMID: 37537212.


7.) Durmus N, Chen WC, Park SH, Marsh LM, Kwon S, Nolan A, Grunig G (2023 Jul 25). Resistin-like Molecule α and Pulmonary Vascular Remodeling: A Multi-Strain Murine Model of Antigen and Urban Ambient Particulate Matter Co-Exposure International Journal of Molecular Sciences, 24(15), 11918. . PMCID: 10418630.


8.) Durmus N, Chen WC, Park SH, Marsh LM, Kwon S, Nolan A, Grunig G (2023 Jul 25). Resistin-like Molecule α and Pulmonary Vascular Remodeling: A Multi-Strain Murine Model of Antigen and Urban Ambient Particulate Matter Co-Exposure. International journal of molecular sciences, 24(15), . . PMID: 37569308.


9.) Glytsou C, Chen X, Zacharioudakis E, Al-Santli W, Zhou H, Nadorp B, Lee S, Lasry A, Sun Z, Papaioannou D, Cammer M, Wang K, Zal T, Zal MA, Carter BZ, Ishizawa J, Tibes R, Tsirigos A, Andreeff M, Gavathiotis E, Aifantis I (2023 Jul 7). Mitophagy Promotes Resistance to BH3 Mimetics in Acute Myeloid Leukemia. Cancer discovery, 13(7), 1656-1677. . PMID: 37088914.


10.) Tu NH, Inoue K, Lewis PK, Khan A, Hwang JH, Chokshi V, Dabovic BB, Selvaraj S, Bhattacharya A, Dubeykovskaya Z, Pinkerton NM, Bunnett NW, Loomis CA, Albertson DG, Schmidt BL (2023 Jun 21). Calcitonin Related Polypeptide Alpha Mediates Oral Cancer Pain Cells, 12(13), 1675. . PMCID: 10341289.


11.) Ortigoza MB, Mobini CL, Rocha HL, Bartlett S, Loomis CA, Weiser JN (2023 Jun 3). Targeting host sialic acids in the upper respiratory tract with a broadly-acting neuraminidase to inhibit influenza virus transmission bioRxiv, (), 2023.06.02.543524. . PMCID: 10312619.


12.) Rodriguez-Rodriguez BA, Ciabattoni GO, Duerr R, Valero-Jimenez AM, Yeung ST, Crosse KM, Schinlever AR, Bernard-Raichon L, Rodriguez Galvan J, McGrath ME, Vashee S, Xue Y, Loomis CA, Khanna KM, Cadwell K, Desvignes L, Frieman MB, Ortigoza MB, Dittmann M (2023 May 25). A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8. Nature communications, 14(1), 3026. . PMID: 37230979.


13.) Sun Q, Lee W, Hu H, Ogawa T, De Leon S, Katehis I, Lim CH, Takeo M, Cammer M, Taketo MM, Gay DL, Millar SE, Ito M (2023 Apr 19). Dedifferentiation maintains melanocyte stem cells in a dynamic niche Nature, 616(7958), 774-782. . PMCID: 10132989.


14.) Sun Q, Lee W, Hu H, Ogawa T, De Leon S, Katehis I, Lim CH, Takeo M, Cammer M, Taketo MM, Gay DL, Millar SE, Ito M (2023 Apr). Dedifferentiation maintains melanocyte stem cells in a dynamic niche. Nature, 616(7958), 774-782. . PMID: 37076619.


15.) Wang YH, Noyer L, Kahlfuss S, Raphael D, Tao AY, Kaufmann U, Zhu J, Mitchell-Flack M, Sidhu I, Zhou F, Vaeth M, Thomas PG, Saunders SP, Stauderman K, Curotto de Lafaille MA, Feske S (2022 Oct 7). Distinct roles of ORAI1 in T cell–mediated allergic airway inflammation and immunity to influenza A virus infection Science Advances, 8(40), eabn6552. . PMCID: 9544339.


16.) Wang YH, Noyer L, Kahlfuss S, Raphael D, Tao AY, Kaufmann U, Zhu J, Mitchell-Flack M, Sidhu I, Zhou F, Vaeth M, Thomas PG, Saunders SP, Stauderman K, Curotto de Lafaille MA, Feske S (2022 Oct 7). Distinct roles of ORAI1 in T cell-mediated allergic airway inflammation and immunity to influenza A virus infection. Science advances, 8(40), eabn6552. . PMID: 36206339.


17.) Kleffman K, Levinson G, Rose IVL, Blumenberg LM, Shadaloey SAA, Dhabaria A, Wong E, Galán-Echevarría F, Karz A, Argibay D, Von Itter R, Floristán A, Baptiste G, Eskow NM, Tranos JA, Chen J, Vega Y Saenz de Miera EC, Call M, Rogers R, Jour G, Wadghiri YZ, Osman I, Li YM, Mathews P, DeMattos RB, Ueberheide B, Ruggles KV, Liddelow SA, Schneider RJ, Hernando E (2022 May 2). Melanoma-Secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis. Cancer discovery, 12(5), 1314-1335. . PMID: 35262173.


Description:

Core provides services, access to instruments, and training to facilitate production of animal tissue samples for morphological and molecular analyses. Supports multiplex immunofluorescence staining, RNA in situ hybridization (ISH), and imaging analysis. \\nServices include tissue preparation, processing, and sectioning, as well as histochemistry and immunohistochemistry of fresh, frozen, and fixed animal tissues, can optimize and validate commercial or proprietary antibodies for chromogenic or fluorescence-based immunohistochemistry including seven-color multiplexing.Provides access to database listing antibodies that have been tested in lab to date and are currently in stock.Offers basic imaging resources and digital whole-slide scanning of stained tissue sections, which allows researchers to view their slides online at their convenience.Researchers can also rent our self-service instruments. These include embedding station, microtome, cryostat, and vibratome. Provides access to brightfield and fluorescence upright and dissecting microscopes,laser capture microdissection scope, and high-throughput multispectral imaging system.To reserve time on instrument, faculty, staff, and investigators must be registered in iLab.