Vanderbilt University

Contact Info:

Jennifer Skelton

9410 MRBIV

2213 Garland Avenue

Nashville, TN 37232

https://medschool.vanderbilt.edu/vger

Grants and Identifiers:

RRID: RRID:SCR_018826

CA68485

DK020593

Instrumentation:

Services Provided:

Animal Husbandry

Assisted Reproductive Technologies (Rodent IVF, ICSI)

CRISPR/Cas Project Design

Embryo Cryopreservation & Recovery Services

Genotyping

Provide Germfree Mice

Rederivation

Repository

Transgenics

Relevant Publications:

1.) Brown ME, Miranda VE, Nevills S, Hu R, Dadi PK, Simmons AJ, Xu Y, Yang Y, Yagan M, Najam S, Sampson LL, Magnuson MA, Jacobson DA, Lau KS, Hodges E, Gu G (2025 Jul 1). Pancreatic islet β-cell subtypes are derived from biochemically-distinct and nutritionally-regulated islet progenitors. Nature communications, 16(1), 5758. . PMID: 40593675.

2.) Momoh M, Adeniran F, Ramos C, DelGiorno KE, Seno H, Roland JT, Kaji I (2025 Mar). Acute tuft cell ablation in mice induces malabsorption and alterations in secretory and immune cell lineages in the small intestine. Physiological reports, 13(5), e70264. . PMID: 40051209.

3.) Trinh LT, Finnel RR, Osipovich AB, Musselman JR, Sampson LL, Wright CV, Magnuson MA (2025 Jan 16). Positive autoregulation of Sox17 is necessary for gallbladder and extrahepatic bile duct formation Development (Cambridge, England), 152(2), dev203033. . PMCID: 11829758.

4.) Momoh M, Adeniran F, Ramos C, DelGiorno KE, Seno H, Roland JT, Kaji I (2024 Sep 22). Acute tuft cell ablation induces malabsorption and alterations in secretory and immune cell lineages in small intestine. bioRxiv : the preprint server for biology, (), . . PMID: 39345424.

5.) Ferdaus MZ, Terker AS, Koumangoye RB, Al-Qusairi L, Welling PA, Delpire E (2024 Sep 1). Deletion of KS-WNK1 promotes NCC activation by increasing WNK1/4 abundance. American journal of physiology. Renal physiology, 327(3), F373-F385. . PMID: 38961847.

6.) Gu G, Brown M, Agan V, Nevills S, Hu R, Simmons A, Xu Y, Yang Y, Yagan M, Najam S, Dadi P, Sampson L, Magnuson M, Jacobson D, Lau K, Hodges E (2024 Mar 7). Endocrine islet β-cell subtypes with differential function are derived from biochemically distinct embryonic endocrine islet progenitors that are regulated by maternal nutrients Research Square, (), rs.3.rs-3946483. . PMCID: 10942487.

7.) Nakhe AY, Dadi PK, Kim J, Dickerson MT, Behera S, Dobson JR, Shrestha S, Cartailler JP, Sampson L, Magnuson MA, Jacobson DA (2024 Feb 27). The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults. bioRxiv : the preprint server for biology, (), . . PMID: 37546831.

8.) Keller MP, Hawes EM, Schueler KL, Stapleton DS, Mitok KA, Simonett SP, Oeser JK, Sampson LL, Attie AD, Magnuson MA, O'Brien RM (2023 Nov 1). An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets. Diabetes, 72(11), 1621-1628. . PMID: 37552875.

9.) Winn NC, Patel VS, Blair JA, Rodriguez A, Garcia JN, Yang TS, Hasty AH (2023 Oct 1). Deletion of complement factor 5 amplifies glucose intolerance in obese male but not female mice. American journal of physiology. Endocrinology and metabolism, 325(4), E325-E335. . PMID: 37610411.

10.) Cencer CS, Silverman JB, Meenderink LM, Krystofiak ES, Millis BA, Tyska MJ (2023 Mar 9). Adhesion-based capture stabilizes nascent microvilli at epithelial cell junctions. bioRxiv : the preprint server for biology, (), . . PMID: 36945471.

11.) Burman A, Momoh M, Sampson L, Skelton J, Roland JT, Ramos C, Krystofiak E, Acra S, Goldenring JR, Kaji I (2023). Modeling of a Novel Patient-Based MYO5B Point Mutation Reveals Insights Into MVID Pathogenesis. Cellular and molecular gastroenterology and hepatology, 15(4), 1022-1026. . PMID: 36592862.

12.) Wu HJ, Mortlock DP, Kuchtey RW, Kuchtey J (2021 Aug 2). Altered Ocular Fibrillin Microfibril Composition in Mice With a Glaucoma-Causing Mutation of Adamts10. Investigative ophthalmology & visual science, 62(10), 26. . PMID: 34424262.

13.) Shumate KM, Tas ST, Kavalali ET, Emeson RB (2021 Jul). RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission. Journal of neurochemistry, 158(2), 182-196. doi: 10.1111/jnc.15372. PMID: 33894004.

Description:

The Vanderbilt Genome Editing Resource (VGER) provides services, consultation, and collaborations to enable the generation, storage and regeneration of genetically altered mice. We have many years of experience in generating novel transgenic mouse models and are happy to discuss your project with you.